Do bone mineral density, trabecular bone score, and hip structural analysis differ in indian men with parkinson's disease? A case-control pilot study from a tertiary center in Southern India
Objective: Parkinson's disease (PD) is a neurodegenerative condition that is characterized by bradykinesia, rigidity, and gait instability. Inherent to this condition is an increased predisposition to falls and fractures. Bone health in Parkinson's disease in India has not been studied thu...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2023;volume=26;issue=4;spage=496;epage=501;aulast=Sooragonda |
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| author | Basavaraj G Sooragonda Kalyani Sridharan Rohit Ninan Benjamin A T Prabhakar Ajith Sivadasan Nitin Kapoor Kripa Elizabeth Cherian Felix K Jebasingh Sanjith Aaron Vivek Mathew Hesarghatta S Asha Nihal Thomas Thomas V Paul |
| author_facet | Basavaraj G Sooragonda Kalyani Sridharan Rohit Ninan Benjamin A T Prabhakar Ajith Sivadasan Nitin Kapoor Kripa Elizabeth Cherian Felix K Jebasingh Sanjith Aaron Vivek Mathew Hesarghatta S Asha Nihal Thomas Thomas V Paul |
| author_sort | Basavaraj G Sooragonda |
| collection | DOAJ |
| description | Objective: Parkinson's disease (PD) is a neurodegenerative condition that is characterized by bradykinesia, rigidity, and gait instability. Inherent to this condition is an increased predisposition to falls and fractures. Bone health in Parkinson's disease in India has not been studied thus far. This study aimed to assess the bone mineral density (BMD), trabecular bone score (TBS), and hip structural analysis (HSA) in Indian men with PD and compare them with matched controls. Methodology: A case-control study done at a tertiary care center from southern India. Bone biochemistry, BMD, TBS, and HSA were assessed. Results: Among 40 cases and 40 age, gender, and body mass index (BMI)-matched controls, there was no significant difference in BMD between both groups. The mean (SD) TBS at the lumbar spine [1.349 (0.090)] was significantly (P = 0.019) lower in men with PD as compared to matched controls [1.401 (0.089)]. Among the parameters of HSA, the buckling ratios were significantly higher at the femoral neck [11.8 (2.2) vs 9.4 (2.2); P = 0.001] and inter-trochanteric region [9.4 (2.1) vs 7.8 (1.4); P = 0.002] among cases as compared to matched controls. Vitamin D deficiency was significantly higher in this cohort of patients as was bone turnover marker indicating bone loss and a high bone turnover state. Conclusion: A comprehensive bone health assessment comprising BMD, TBS, and HSA may be required to capture all aspects of bone strength in Indian men with PD as BMD assessment as a stand-alone tool may not suffice to obtain all information pertaining to fracture risk in these individuals. |
| first_indexed | 2024-03-11T15:47:52Z |
| format | Article |
| id | doaj.art-352acda7fdc24979893d4a5b5ad288eb |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-03-11T15:47:52Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-352acda7fdc24979893d4a5b5ad288eb2023-10-26T05:44:42ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492023-01-0126449650110.4103/aian.aian_29_23Do bone mineral density, trabecular bone score, and hip structural analysis differ in indian men with parkinson's disease? A case-control pilot study from a tertiary center in Southern IndiaBasavaraj G SooragondaKalyani SridharanRohit Ninan BenjaminA T PrabhakarAjith SivadasanNitin KapoorKripa Elizabeth CherianFelix K JebasinghSanjith AaronVivek MathewHesarghatta S AshaNihal ThomasThomas V PaulObjective: Parkinson's disease (PD) is a neurodegenerative condition that is characterized by bradykinesia, rigidity, and gait instability. Inherent to this condition is an increased predisposition to falls and fractures. Bone health in Parkinson's disease in India has not been studied thus far. This study aimed to assess the bone mineral density (BMD), trabecular bone score (TBS), and hip structural analysis (HSA) in Indian men with PD and compare them with matched controls. Methodology: A case-control study done at a tertiary care center from southern India. Bone biochemistry, BMD, TBS, and HSA were assessed. Results: Among 40 cases and 40 age, gender, and body mass index (BMI)-matched controls, there was no significant difference in BMD between both groups. The mean (SD) TBS at the lumbar spine [1.349 (0.090)] was significantly (P = 0.019) lower in men with PD as compared to matched controls [1.401 (0.089)]. Among the parameters of HSA, the buckling ratios were significantly higher at the femoral neck [11.8 (2.2) vs 9.4 (2.2); P = 0.001] and inter-trochanteric region [9.4 (2.1) vs 7.8 (1.4); P = 0.002] among cases as compared to matched controls. Vitamin D deficiency was significantly higher in this cohort of patients as was bone turnover marker indicating bone loss and a high bone turnover state. Conclusion: A comprehensive bone health assessment comprising BMD, TBS, and HSA may be required to capture all aspects of bone strength in Indian men with PD as BMD assessment as a stand-alone tool may not suffice to obtain all information pertaining to fracture risk in these individuals.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2023;volume=26;issue=4;spage=496;epage=501;aulast=Sooragondabone mineral densityhip structural analysisparkinson's diseasetrabecular bone score |
| spellingShingle | Basavaraj G Sooragonda Kalyani Sridharan Rohit Ninan Benjamin A T Prabhakar Ajith Sivadasan Nitin Kapoor Kripa Elizabeth Cherian Felix K Jebasingh Sanjith Aaron Vivek Mathew Hesarghatta S Asha Nihal Thomas Thomas V Paul Do bone mineral density, trabecular bone score, and hip structural analysis differ in indian men with parkinson's disease? A case-control pilot study from a tertiary center in Southern India Annals of Indian Academy of Neurology bone mineral density hip structural analysis parkinson's disease trabecular bone score |
| title | Do bone mineral density, trabecular bone score, and hip structural analysis differ in indian men with parkinson's disease? A case-control pilot study from a tertiary center in Southern India |
| title_full | Do bone mineral density, trabecular bone score, and hip structural analysis differ in indian men with parkinson's disease? A case-control pilot study from a tertiary center in Southern India |
| title_fullStr | Do bone mineral density, trabecular bone score, and hip structural analysis differ in indian men with parkinson's disease? A case-control pilot study from a tertiary center in Southern India |
| title_full_unstemmed | Do bone mineral density, trabecular bone score, and hip structural analysis differ in indian men with parkinson's disease? A case-control pilot study from a tertiary center in Southern India |
| title_short | Do bone mineral density, trabecular bone score, and hip structural analysis differ in indian men with parkinson's disease? A case-control pilot study from a tertiary center in Southern India |
| title_sort | do bone mineral density trabecular bone score and hip structural analysis differ in indian men with parkinson s disease a case control pilot study from a tertiary center in southern india |
| topic | bone mineral density hip structural analysis parkinson's disease trabecular bone score |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2023;volume=26;issue=4;spage=496;epage=501;aulast=Sooragonda |
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