Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape

Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape

We report here a combined anti-cancer therapy directed toward HER2 and EpCAM, common tumor-associated antigens of breast cancer cells. The combined therapeutic effect is achieved owing to two highly toxic proteins—a low immunogenic variant of <i>Pseudomonas aeruginosa</i> exotoxin A and...

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Bibliographic Details
Main Authors: Elena Shramova, Galina Proshkina, Victoria Shipunova, Anastasia Ryabova, Roman Kamyshinsky, Andrey Konevega, Aleksey Schulga, Elena Konovalova, Georgij Telegin, Sergey Deyev
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
Barnase
liposomes
HER2
EpCAM
cancer therapy
Online Access:https://www.mdpi.com/2072-6694/12/10/3014

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