Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study
Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the assoc...
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| Format: | Article |
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BMC
2021-06-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-021-02307-6 |
| _version_ | 1829531260345647104 |
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| author | Jing Xiao Jingyi Lv Shiyu Wang Yang Zhou Lunwen Chen Juying Lu Xiaoyi Zhang Xiaojian Wang Yunjuan Gu Qingyun Lu |
| author_facet | Jing Xiao Jingyi Lv Shiyu Wang Yang Zhou Lunwen Chen Juying Lu Xiaoyi Zhang Xiaojian Wang Yunjuan Gu Qingyun Lu |
| author_sort | Jing Xiao |
| collection | DOAJ |
| description | Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China. |
| first_indexed | 2024-12-16T18:18:30Z |
| format | Article |
| id | doaj.art-352e53875e604960ba849a77993bd84b |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-16T18:18:30Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
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| series | BMC Geriatrics |
| spelling | doaj.art-352e53875e604960ba849a77993bd84b2022-12-21T22:21:38ZengBMCBMC Geriatrics1471-23182021-06-0121111210.1186/s12877-021-02307-6Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization studyJing Xiao0Jingyi Lv1Shiyu Wang2Yang Zhou3Lunwen Chen4Juying Lu5Xiaoyi Zhang6Xiaojian Wang7Yunjuan Gu8Qingyun Lu9Department of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityDepartment of Chronic Disease and Prevention, Center for Disease Control and Prevention of HaianDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityAbstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.https://doi.org/10.1186/s12877-021-02307-625-hydroxyvitamin DGenetic risk scoresMendelian randomizationMetabolic syndromeType 2 diabetes |
| spellingShingle | Jing Xiao Jingyi Lv Shiyu Wang Yang Zhou Lunwen Chen Juying Lu Xiaoyi Zhang Xiaojian Wang Yunjuan Gu Qingyun Lu Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study BMC Geriatrics 25-hydroxyvitamin D Genetic risk scores Mendelian randomization Metabolic syndrome Type 2 diabetes |
| title | Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study |
| title_full | Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study |
| title_fullStr | Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study |
| title_full_unstemmed | Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study |
| title_short | Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study |
| title_sort | association of serum 25 hydroxyvitamin d with metabolic syndrome and type 2 diabetes a one sample mendelian randomization study |
| topic | 25-hydroxyvitamin D Genetic risk scores Mendelian randomization Metabolic syndrome Type 2 diabetes |
| url | https://doi.org/10.1186/s12877-021-02307-6 |
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