Lipid Messenger Phosphatidylinositol-4,5-Bisphosphate Is Increased by Both PPARα Activators and Inhibitors: Relevance for Intestinal Cell Differentiation

We investigated the effects of PPARα activators fenofibrate and WY-14643 as well as the PPARα inhibitor GW6471 on the PI3K/Akt/PTEN pathway of intestinal cell differentiation. Our previous study showed that all these compounds increased the expression of villin, a specific marker of intestinal cell...

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Bibliographic Details
Main Authors: Katerina Cizkova, Katerina Koubova, Zdenek Tauber
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biology
Subjects:
Online Access:https://www.mdpi.com/2079-7737/11/7/997