Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration
Summary: Desert animals have evolved systems that enable them to thrive under dry conditions. Focusing on the kidney, we have investigated the transcriptomic adaptations that enable a desert rodent, the Lesser Egyptian Jerboa (Jaculus jaculus), to withstand water deprivation and opportunistic rehydr...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223016516 |
| _version_ | 1797738919267139584 |
|---|---|
| author | Benjamin T. Gillard Nabil Amor Fernando Alvira Iraizoz Audrys G. Pauža Colin Campbell Michael P. Greenwood Abdulaziz N. Alagaili David Murphy |
| author_facet | Benjamin T. Gillard Nabil Amor Fernando Alvira Iraizoz Audrys G. Pauža Colin Campbell Michael P. Greenwood Abdulaziz N. Alagaili David Murphy |
| author_sort | Benjamin T. Gillard |
| collection | DOAJ |
| description | Summary: Desert animals have evolved systems that enable them to thrive under dry conditions. Focusing on the kidney, we have investigated the transcriptomic adaptations that enable a desert rodent, the Lesser Egyptian Jerboa (Jaculus jaculus), to withstand water deprivation and opportunistic rehydration. Analysis of the whole kidney transcriptome showed many differentially expressed genes in the Jerboa kidney, 6.4% of genes following dehydration and an even greater number (36.2%) following rehydration compared to control. Genes correlated with the rehydration condition included many ribosomal protein coding genes suggesting a concerted effort to accelerate protein synthesis when water is made available. We identify an increase in TGF-beta signaling antagonists in dehydration (e.g., GREM2). We also describe expression of multiple aquaporin and solute carrier transporters mapped to specific nephron segments. The desert adapted renal transcriptome presented here is a valuable resource to expand our understanding of osmoregulation beyond that derived from model organisms. |
| first_indexed | 2024-03-12T13:50:47Z |
| format | Article |
| id | doaj.art-352e77dbd6474e4c9fdb2dc5d93a1b07 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T13:50:47Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-352e77dbd6474e4c9fdb2dc5d93a1b072023-08-23T04:33:49ZengElsevieriScience2589-00422023-09-01269107574Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydrationBenjamin T. Gillard0Nabil Amor1Fernando Alvira Iraizoz2Audrys G. Pauža3Colin Campbell4Michael P. Greenwood5Abdulaziz N. Alagaili6David Murphy7Molecular Neuroendocrinology Research Group, Bristol Medical School: Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, EnglandLR18ES05, Laboratory of Biodiversity, Parasitology and Ecology of Aquatic Ecosystems, Department of Biology - Faculty of Sciences of Tunis, University of Tunis El Manar, TunisiaMolecular Neuroendocrinology Research Group, Bristol Medical School: Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, EnglandMolecular Neuroendocrinology Research Group, Bristol Medical School: Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, EnglandDepartment of Engineering Mathematics, Ada Lovelace Building, University of Bristol, Bristol, EnglandMolecular Neuroendocrinology Research Group, Bristol Medical School: Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, EnglandDepartment of Zoology, King Saud University, Riyadh, Kingdom of Saudi ArabiaMolecular Neuroendocrinology Research Group, Bristol Medical School: Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, England; Corresponding authorSummary: Desert animals have evolved systems that enable them to thrive under dry conditions. Focusing on the kidney, we have investigated the transcriptomic adaptations that enable a desert rodent, the Lesser Egyptian Jerboa (Jaculus jaculus), to withstand water deprivation and opportunistic rehydration. Analysis of the whole kidney transcriptome showed many differentially expressed genes in the Jerboa kidney, 6.4% of genes following dehydration and an even greater number (36.2%) following rehydration compared to control. Genes correlated with the rehydration condition included many ribosomal protein coding genes suggesting a concerted effort to accelerate protein synthesis when water is made available. We identify an increase in TGF-beta signaling antagonists in dehydration (e.g., GREM2). We also describe expression of multiple aquaporin and solute carrier transporters mapped to specific nephron segments. The desert adapted renal transcriptome presented here is a valuable resource to expand our understanding of osmoregulation beyond that derived from model organisms.http://www.sciencedirect.com/science/article/pii/S2589004223016516AnimalsEnvironmentExposureTranscriptomics |
| spellingShingle | Benjamin T. Gillard Nabil Amor Fernando Alvira Iraizoz Audrys G. Pauža Colin Campbell Michael P. Greenwood Abdulaziz N. Alagaili David Murphy Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration iScience Animals Environment Exposure Transcriptomics |
| title | Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration |
| title_full | Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration |
| title_fullStr | Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration |
| title_full_unstemmed | Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration |
| title_short | Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration |
| title_sort | mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration |
| topic | Animals Environment Exposure Transcriptomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223016516 |
| work_keys_str_mv | AT benjamintgillard mobilisationofjerboakidneygenenetworksduringdehydrationandopportunisticrehydration AT nabilamor mobilisationofjerboakidneygenenetworksduringdehydrationandopportunisticrehydration AT fernandoalvirairaizoz mobilisationofjerboakidneygenenetworksduringdehydrationandopportunisticrehydration AT audrysgpauza mobilisationofjerboakidneygenenetworksduringdehydrationandopportunisticrehydration AT colincampbell mobilisationofjerboakidneygenenetworksduringdehydrationandopportunisticrehydration AT michaelpgreenwood mobilisationofjerboakidneygenenetworksduringdehydrationandopportunisticrehydration AT abdulaziznalagaili mobilisationofjerboakidneygenenetworksduringdehydrationandopportunisticrehydration AT davidmurphy mobilisationofjerboakidneygenenetworksduringdehydrationandopportunisticrehydration |