Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy
A magnetic nanocomposite, consisting of Fe<sub>3</sub>O<sub>4</sub> nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug deliv...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/7/1796 |
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| author | Konstantinos Simeonidis Efthimia Kaprara Pilar Rivera-Gil Ruixue Xu Francisco J. Teran Evgenios Kokkinos Athanassios Mitropoulos Nikolaos Maniotis Lluis Balcells |
| author_facet | Konstantinos Simeonidis Efthimia Kaprara Pilar Rivera-Gil Ruixue Xu Francisco J. Teran Evgenios Kokkinos Athanassios Mitropoulos Nikolaos Maniotis Lluis Balcells |
| author_sort | Konstantinos Simeonidis |
| collection | DOAJ |
| description | A magnetic nanocomposite, consisting of Fe<sub>3</sub>O<sub>4</sub> nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the sequential hydrolysis of iron salts (Fe<sup>2+</sup>, Fe<sup>3+</sup>) and Mg<sup>2+</sup>/Al<sup>3+</sup> nitrates in a carbonate-rich mild alkaline environment followed by the loading of 5-fluorouracil, an anionic anticancer drug, in the interlayer LDH space. Magnetite nanoparticles with a diameter around 30 nm, dispersed in water, constitute the hyperthermia-active phase able to generate a specific loss of power of around 500 W/g-Fe in an alternating current (AC) magnetic field of 24 kA/m and 300 kHz as determined by AC magnetometry and calorimetric measurements. Heat transfer was found to trigger a very rapid release of drug which reached 80% of the loaded mass within 10 min exposure to the applied field. The potential of the Fe<sub>3</sub>O<sub>4</sub>/LDH nanocomposites as cancer treatment agents with minimum side-effects, owing to the exclusive presence of inorganic phases, was validated by cell internalization and toxicity assays. |
| first_indexed | 2024-03-10T09:29:19Z |
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| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T09:29:19Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-352f6ac0b8ba4e35b12350b822d97fb52023-11-22T04:34:01ZengMDPI AGNanomaterials2079-49912021-07-01117179610.3390/nano11071796Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered ChemotherapyKonstantinos Simeonidis0Efthimia Kaprara1Pilar Rivera-Gil2Ruixue Xu3Francisco J. Teran4Evgenios Kokkinos5Athanassios Mitropoulos6Nikolaos Maniotis7Lluis Balcells8Department of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceIntegrative Biomedical Materials and Nanomedicine Lab, Universitat Pompeu Fabra, 08003 Barcelona, SpainIntegrative Biomedical Materials and Nanomedicine Lab, Universitat Pompeu Fabra, 08003 Barcelona, SpainIMDEA-Nanociencia, Ciudad Universitaria de Cantoblanco, 28049 Madrid, SpainEcoresources P.C., Giannitson-Santaroza Str. 15-17, 54627 Thessaloniki, GreeceHephaestus Advanced Laboratory, Department of Chemistry, International Hellenic University, 65404 Kavala, GreeceDepartment of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceInstitut de Ciencia de Materials de Barcelona, CSIC, 08193 Bellaterra, SpainA magnetic nanocomposite, consisting of Fe<sub>3</sub>O<sub>4</sub> nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the sequential hydrolysis of iron salts (Fe<sup>2+</sup>, Fe<sup>3+</sup>) and Mg<sup>2+</sup>/Al<sup>3+</sup> nitrates in a carbonate-rich mild alkaline environment followed by the loading of 5-fluorouracil, an anionic anticancer drug, in the interlayer LDH space. Magnetite nanoparticles with a diameter around 30 nm, dispersed in water, constitute the hyperthermia-active phase able to generate a specific loss of power of around 500 W/g-Fe in an alternating current (AC) magnetic field of 24 kA/m and 300 kHz as determined by AC magnetometry and calorimetric measurements. Heat transfer was found to trigger a very rapid release of drug which reached 80% of the loaded mass within 10 min exposure to the applied field. The potential of the Fe<sub>3</sub>O<sub>4</sub>/LDH nanocomposites as cancer treatment agents with minimum side-effects, owing to the exclusive presence of inorganic phases, was validated by cell internalization and toxicity assays.https://www.mdpi.com/2079-4991/11/7/1796layered double hydroxideFe<sub>3</sub>O<sub>4</sub>continuous flow synthesismagnetic hyperthermiananocompositedrug delivery |
| spellingShingle | Konstantinos Simeonidis Efthimia Kaprara Pilar Rivera-Gil Ruixue Xu Francisco J. Teran Evgenios Kokkinos Athanassios Mitropoulos Nikolaos Maniotis Lluis Balcells Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy Nanomaterials layered double hydroxide Fe<sub>3</sub>O<sub>4</sub> continuous flow synthesis magnetic hyperthermia nanocomposite drug delivery |
| title | Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy |
| title_full | Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy |
| title_fullStr | Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy |
| title_full_unstemmed | Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy |
| title_short | Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy |
| title_sort | hydrotalcite embedded magnetite nanoparticles for hyperthermia triggered chemotherapy |
| topic | layered double hydroxide Fe<sub>3</sub>O<sub>4</sub> continuous flow synthesis magnetic hyperthermia nanocomposite drug delivery |
| url | https://www.mdpi.com/2079-4991/11/7/1796 |
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