The Role of Temperate Phages in Bacterial Pathogenicity
Bacteriophages are viruses that infect bacteria and archaea and are classified as virulent or temperate phages based on their life cycles. A temperate phage, also known as a lysogenic phage, integrates its genomes into host bacterial chromosomes as a prophage. Previous studies have indicated that te...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/3/541 |
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| author | Vimathi S. Gummalla Yujie Zhang Yen-Te Liao Vivian C. H. Wu |
| author_facet | Vimathi S. Gummalla Yujie Zhang Yen-Te Liao Vivian C. H. Wu |
| author_sort | Vimathi S. Gummalla |
| collection | DOAJ |
| description | Bacteriophages are viruses that infect bacteria and archaea and are classified as virulent or temperate phages based on their life cycles. A temperate phage, also known as a lysogenic phage, integrates its genomes into host bacterial chromosomes as a prophage. Previous studies have indicated that temperate phages are beneficial to their susceptible bacterial hosts by introducing additional genes to bacterial chromosomes, creating a mutually beneficial relationship. This article reviewed three primary ways temperate phages contribute to the bacterial pathogenicity of foodborne pathogens, including phage-mediated virulence gene transfer, antibiotic resistance gene mobilization, and biofilm formation. This study provides insights into mechanisms of phage–bacterium interactions in the context of foodborne pathogens and provokes new considerations for further research to avoid the potential of phage-mediated harmful gene transfer in agricultural environments. |
| first_indexed | 2024-03-11T06:09:06Z |
| format | Article |
| id | doaj.art-352fdd0dba7d4944ad262d6b946ac13e |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T06:09:06Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-352fdd0dba7d4944ad262d6b946ac13e2023-11-17T12:44:35ZengMDPI AGMicroorganisms2076-26072023-02-0111354110.3390/microorganisms11030541The Role of Temperate Phages in Bacterial PathogenicityVimathi S. Gummalla0Yujie Zhang1Yen-Te Liao2Vivian C. H. Wu3Produce Safety and Microbiology Research Unit, U.S. Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Albany, CA 94710, USAProduce Safety and Microbiology Research Unit, U.S. Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Albany, CA 94710, USAProduce Safety and Microbiology Research Unit, U.S. Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Albany, CA 94710, USAProduce Safety and Microbiology Research Unit, U.S. Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Albany, CA 94710, USABacteriophages are viruses that infect bacteria and archaea and are classified as virulent or temperate phages based on their life cycles. A temperate phage, also known as a lysogenic phage, integrates its genomes into host bacterial chromosomes as a prophage. Previous studies have indicated that temperate phages are beneficial to their susceptible bacterial hosts by introducing additional genes to bacterial chromosomes, creating a mutually beneficial relationship. This article reviewed three primary ways temperate phages contribute to the bacterial pathogenicity of foodborne pathogens, including phage-mediated virulence gene transfer, antibiotic resistance gene mobilization, and biofilm formation. This study provides insights into mechanisms of phage–bacterium interactions in the context of foodborne pathogens and provokes new considerations for further research to avoid the potential of phage-mediated harmful gene transfer in agricultural environments.https://www.mdpi.com/2076-2607/11/3/541temperate phagesfoodborne pathogenshorizontal gene transfervirulence factorsantibiotic resistance genesbiofilm formation |
| spellingShingle | Vimathi S. Gummalla Yujie Zhang Yen-Te Liao Vivian C. H. Wu The Role of Temperate Phages in Bacterial Pathogenicity Microorganisms temperate phages foodborne pathogens horizontal gene transfer virulence factors antibiotic resistance genes biofilm formation |
| title | The Role of Temperate Phages in Bacterial Pathogenicity |
| title_full | The Role of Temperate Phages in Bacterial Pathogenicity |
| title_fullStr | The Role of Temperate Phages in Bacterial Pathogenicity |
| title_full_unstemmed | The Role of Temperate Phages in Bacterial Pathogenicity |
| title_short | The Role of Temperate Phages in Bacterial Pathogenicity |
| title_sort | role of temperate phages in bacterial pathogenicity |
| topic | temperate phages foodborne pathogens horizontal gene transfer virulence factors antibiotic resistance genes biofilm formation |
| url | https://www.mdpi.com/2076-2607/11/3/541 |
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