Functions of Rab Proteins at Presynaptic Sites
Presynaptic neurotransmitter release is dominated by the synaptic vesicle (SV) cycle and entails the biogenesis, fusion, recycling, reformation or turnover of synaptic vesicles—a process involving bulk movement of membrane and proteins. As key mediators of membrane trafficking, small GTPases from th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-02-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/5/1/7 |
| _version_ | 1797700970275143680 |
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| author | Beyenech Binotti Reinhard Jahn John Jia En Chua |
| author_facet | Beyenech Binotti Reinhard Jahn John Jia En Chua |
| author_sort | Beyenech Binotti |
| collection | DOAJ |
| description | Presynaptic neurotransmitter release is dominated by the synaptic vesicle (SV) cycle and entails the biogenesis, fusion, recycling, reformation or turnover of synaptic vesicles—a process involving bulk movement of membrane and proteins. As key mediators of membrane trafficking, small GTPases from the Rab family of proteins play critical roles in this process by acting as molecular switches that dynamically interact with and regulate the functions of different sets of macromolecular complexes involved in each stage of the cycle. Importantly, mutations affecting Rabs, and their regulators or effectors have now been identified that are implicated in severe neurological and neurodevelopmental disorders. Here, we summarize the roles and functions of presynaptic Rabs and discuss their involvement in the regulation of presynaptic function. |
| first_indexed | 2024-03-12T04:28:35Z |
| format | Article |
| id | doaj.art-3530f6b63be8424b9d68da32268f511d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T04:28:35Z |
| publishDate | 2016-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3530f6b63be8424b9d68da32268f511d2023-09-03T10:10:37ZengMDPI AGCells2073-44092016-02-0151710.3390/cells5010007cells5010007Functions of Rab Proteins at Presynaptic SitesBeyenech Binotti0Reinhard Jahn1John Jia En Chua2Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen 37077, GermanyDepartment of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen 37077, GermanyInteractomics and Intracellular Trafficking laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, SingaporePresynaptic neurotransmitter release is dominated by the synaptic vesicle (SV) cycle and entails the biogenesis, fusion, recycling, reformation or turnover of synaptic vesicles—a process involving bulk movement of membrane and proteins. As key mediators of membrane trafficking, small GTPases from the Rab family of proteins play critical roles in this process by acting as molecular switches that dynamically interact with and regulate the functions of different sets of macromolecular complexes involved in each stage of the cycle. Importantly, mutations affecting Rabs, and their regulators or effectors have now been identified that are implicated in severe neurological and neurodevelopmental disorders. Here, we summarize the roles and functions of presynaptic Rabs and discuss their involvement in the regulation of presynaptic function.http://www.mdpi.com/2073-4409/5/1/7Presynapsesynaptic transmissionsmall GTPasesRabsintracellular membrane traffickingsynaptic vesicle cycleautophagy |
| spellingShingle | Beyenech Binotti Reinhard Jahn John Jia En Chua Functions of Rab Proteins at Presynaptic Sites Cells Presynapse synaptic transmission small GTPases Rabs intracellular membrane trafficking synaptic vesicle cycle autophagy |
| title | Functions of Rab Proteins at Presynaptic Sites |
| title_full | Functions of Rab Proteins at Presynaptic Sites |
| title_fullStr | Functions of Rab Proteins at Presynaptic Sites |
| title_full_unstemmed | Functions of Rab Proteins at Presynaptic Sites |
| title_short | Functions of Rab Proteins at Presynaptic Sites |
| title_sort | functions of rab proteins at presynaptic sites |
| topic | Presynapse synaptic transmission small GTPases Rabs intracellular membrane trafficking synaptic vesicle cycle autophagy |
| url | http://www.mdpi.com/2073-4409/5/1/7 |
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