A two-dimensional speckle-tracking echocardiography for the diagnosis of early myocardial disease in beta-thalassemia major patients
Background : Although magnetic resonance imaging T2* is considered the gold standard to assess myocardial iron overload in β-thalassemia patients, its routine use is limited by the high cost and limited availability. Recent data demonstrated that strain imaging by speckle tracking is a sensitive too...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Annals of Pediatric Cardiology |
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| Online Access: | http://www.annalspc.com/article.asp?issn=0974-2069;year=2022;volume=15;issue=3;spage=257;epage=265;aulast=Tantawy |
| _version_ | 1811295400163803136 |
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| author | Azza Abdel Gawad Tantawy Nayera H K Elsherif Neveen M Habeeb Esraa M Hasan Abdelhameed E Abdelhameed |
| author_facet | Azza Abdel Gawad Tantawy Nayera H K Elsherif Neveen M Habeeb Esraa M Hasan Abdelhameed E Abdelhameed |
| author_sort | Azza Abdel Gawad Tantawy |
| collection | DOAJ |
| description | Background : Although magnetic resonance imaging T2* is considered the gold standard to assess myocardial iron overload in β-thalassemia patients, its routine use is limited by the high cost and limited availability. Recent data demonstrated that strain imaging by speckle tracking is a sensitive tool for early assessment of the left ventricular myocardial dysfunction. This study aims to evaluate the clinical utility of two-dimensional (2D) speckle-tracking echocardiography (STE) for the detection of early myocardial disease in beta-thalassemia major (β-TM) patients
Materials and Methods : 2D STE, magnetic resonance imaging (MRI) heart T2* and MRI liver iron content were done for 30 β-TM patients with no clinical heart disease, compared to 2D STE in 30 healthy age- and sex-matched controls.
Results : There was a significant reduction in the longitudinal systolic strain values by STE among β-TM patients compared to controls (P = 0.05). A longitudinal peak systolic strain cutoff values of ≤-19 was able to detect β-TM patients having subclinical cardiac iron overload by MRI T2* (sensitivity = 90%–93.3%, specificity = 83%–100%). Mean serum ferritin in the past 2 years correlated negatively to longitudinal systolic strain values global longitudinal peak systolic strain average (P = 0.05).
Conclusions : STE techniques are an alternative method to detect early myocardial disease before clinical systolic dysfunction in β-TM patients. |
| first_indexed | 2024-04-13T05:32:55Z |
| format | Article |
| id | doaj.art-3530ffb6606b48a08c84c5811c1296fe |
| institution | Directory Open Access Journal |
| issn | 0974-2069 |
| language | English |
| last_indexed | 2024-04-13T05:32:55Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Pediatric Cardiology |
| spelling | doaj.art-3530ffb6606b48a08c84c5811c1296fe2022-12-22T03:00:23ZengWolters Kluwer Medknow PublicationsAnnals of Pediatric Cardiology0974-20692022-01-0115325726510.4103/apc.apc_91_21A two-dimensional speckle-tracking echocardiography for the diagnosis of early myocardial disease in beta-thalassemia major patientsAzza Abdel Gawad TantawyNayera H K ElsherifNeveen M HabeebEsraa M HasanAbdelhameed E AbdelhameedBackground : Although magnetic resonance imaging T2* is considered the gold standard to assess myocardial iron overload in β-thalassemia patients, its routine use is limited by the high cost and limited availability. Recent data demonstrated that strain imaging by speckle tracking is a sensitive tool for early assessment of the left ventricular myocardial dysfunction. This study aims to evaluate the clinical utility of two-dimensional (2D) speckle-tracking echocardiography (STE) for the detection of early myocardial disease in beta-thalassemia major (β-TM) patients Materials and Methods : 2D STE, magnetic resonance imaging (MRI) heart T2* and MRI liver iron content were done for 30 β-TM patients with no clinical heart disease, compared to 2D STE in 30 healthy age- and sex-matched controls. Results : There was a significant reduction in the longitudinal systolic strain values by STE among β-TM patients compared to controls (P = 0.05). A longitudinal peak systolic strain cutoff values of ≤-19 was able to detect β-TM patients having subclinical cardiac iron overload by MRI T2* (sensitivity = 90%–93.3%, specificity = 83%–100%). Mean serum ferritin in the past 2 years correlated negatively to longitudinal systolic strain values global longitudinal peak systolic strain average (P = 0.05). Conclusions : STE techniques are an alternative method to detect early myocardial disease before clinical systolic dysfunction in β-TM patients.http://www.annalspc.com/article.asp?issn=0974-2069;year=2022;volume=15;issue=3;spage=257;epage=265;aulast=Tantawybeta-thalassemiairon overloadmagnetic resonance imagingspeckle-tracking echocardiography |
| spellingShingle | Azza Abdel Gawad Tantawy Nayera H K Elsherif Neveen M Habeeb Esraa M Hasan Abdelhameed E Abdelhameed A two-dimensional speckle-tracking echocardiography for the diagnosis of early myocardial disease in beta-thalassemia major patients Annals of Pediatric Cardiology beta-thalassemia iron overload magnetic resonance imaging speckle-tracking echocardiography |
| title | A two-dimensional speckle-tracking echocardiography for the diagnosis of early myocardial disease in beta-thalassemia major patients |
| title_full | A two-dimensional speckle-tracking echocardiography for the diagnosis of early myocardial disease in beta-thalassemia major patients |
| title_fullStr | A two-dimensional speckle-tracking echocardiography for the diagnosis of early myocardial disease in beta-thalassemia major patients |
| title_full_unstemmed | A two-dimensional speckle-tracking echocardiography for the diagnosis of early myocardial disease in beta-thalassemia major patients |
| title_short | A two-dimensional speckle-tracking echocardiography for the diagnosis of early myocardial disease in beta-thalassemia major patients |
| title_sort | two dimensional speckle tracking echocardiography for the diagnosis of early myocardial disease in beta thalassemia major patients |
| topic | beta-thalassemia iron overload magnetic resonance imaging speckle-tracking echocardiography |
| url | http://www.annalspc.com/article.asp?issn=0974-2069;year=2022;volume=15;issue=3;spage=257;epage=265;aulast=Tantawy |
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