Bio-C (Modified Hyaluronic Acid-Coated-Collagen Tube) Implants Enable Functional Recovery after Complete Spinal Cord Injury
Neural repair within the central nervous system (CNS) has been extremely challenging due to limited abilities of adult CNS neurons to regenerate, particularly in a highly inflammatory injury environment that is also filled with myelin debris. Spinal cord injury (SCI) is a serious medical condition t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/3/596 |
| _version_ | 1797443545708101632 |
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| author | Changhong Zheng Huina Zhang Yanling Cui Yuchen Mu Kun Jiang Liqiang Zhou Junbang Wang Jiping Liu Yaxuan Deng Chunxue Zhang Wenmin Zhu Kongyan Wu Yi Eve Sun |
| author_facet | Changhong Zheng Huina Zhang Yanling Cui Yuchen Mu Kun Jiang Liqiang Zhou Junbang Wang Jiping Liu Yaxuan Deng Chunxue Zhang Wenmin Zhu Kongyan Wu Yi Eve Sun |
| author_sort | Changhong Zheng |
| collection | DOAJ |
| description | Neural repair within the central nervous system (CNS) has been extremely challenging due to limited abilities of adult CNS neurons to regenerate, particularly in a highly inflammatory injury environment that is also filled with myelin debris. Spinal cord injury (SCI) is a serious medical condition that often leads to paralysis and currently has no effective treatment. Here we report the construction of a novel biocompatible and biodegradable material, Bio-C, through coating of acid-desalted-collagen (ADC) tube with pre-modified hyaluronic acid, which, after implantation, can elicit quite robust neural regeneration and functional recovery after complete spinal-cord transection with a 2 mm–spinal-cord-segment removal in mice. We combined morphological, electrophysiological, and objective transcriptomic analyses, in addition to behavioral analyses, to demonstrate neural tissue regeneration and functional recovery through the establishment of Bio-C-induced anti-inflammatory, neurogenic, and neurotrophic microenvironment. Through this study, we unveiled the underlying logic for CNS neural repair. |
| first_indexed | 2024-03-09T12:58:36Z |
| format | Article |
| id | doaj.art-35318c9520cd4406bb5b39e5e7cab21a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T12:58:36Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-35318c9520cd4406bb5b39e5e7cab21a2023-11-30T21:57:10ZengMDPI AGPharmaceutics1999-49232022-03-0114359610.3390/pharmaceutics14030596Bio-C (Modified Hyaluronic Acid-Coated-Collagen Tube) Implants Enable Functional Recovery after Complete Spinal Cord InjuryChanghong Zheng0Huina Zhang1Yanling Cui2Yuchen Mu3Kun Jiang4Liqiang Zhou5Junbang Wang6Jiping Liu7Yaxuan Deng8Chunxue Zhang9Wenmin Zhu10Kongyan Wu11Yi Eve Sun12Stem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaStem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaNeural repair within the central nervous system (CNS) has been extremely challenging due to limited abilities of adult CNS neurons to regenerate, particularly in a highly inflammatory injury environment that is also filled with myelin debris. Spinal cord injury (SCI) is a serious medical condition that often leads to paralysis and currently has no effective treatment. Here we report the construction of a novel biocompatible and biodegradable material, Bio-C, through coating of acid-desalted-collagen (ADC) tube with pre-modified hyaluronic acid, which, after implantation, can elicit quite robust neural regeneration and functional recovery after complete spinal-cord transection with a 2 mm–spinal-cord-segment removal in mice. We combined morphological, electrophysiological, and objective transcriptomic analyses, in addition to behavioral analyses, to demonstrate neural tissue regeneration and functional recovery through the establishment of Bio-C-induced anti-inflammatory, neurogenic, and neurotrophic microenvironment. Through this study, we unveiled the underlying logic for CNS neural repair.https://www.mdpi.com/1999-4923/14/3/596Bio-Cspinal cord injury (SCI)neurotrophicanti-inflammatoryADC |
| spellingShingle | Changhong Zheng Huina Zhang Yanling Cui Yuchen Mu Kun Jiang Liqiang Zhou Junbang Wang Jiping Liu Yaxuan Deng Chunxue Zhang Wenmin Zhu Kongyan Wu Yi Eve Sun Bio-C (Modified Hyaluronic Acid-Coated-Collagen Tube) Implants Enable Functional Recovery after Complete Spinal Cord Injury Pharmaceutics Bio-C spinal cord injury (SCI) neurotrophic anti-inflammatory ADC |
| title | Bio-C (Modified Hyaluronic Acid-Coated-Collagen Tube) Implants Enable Functional Recovery after Complete Spinal Cord Injury |
| title_full | Bio-C (Modified Hyaluronic Acid-Coated-Collagen Tube) Implants Enable Functional Recovery after Complete Spinal Cord Injury |
| title_fullStr | Bio-C (Modified Hyaluronic Acid-Coated-Collagen Tube) Implants Enable Functional Recovery after Complete Spinal Cord Injury |
| title_full_unstemmed | Bio-C (Modified Hyaluronic Acid-Coated-Collagen Tube) Implants Enable Functional Recovery after Complete Spinal Cord Injury |
| title_short | Bio-C (Modified Hyaluronic Acid-Coated-Collagen Tube) Implants Enable Functional Recovery after Complete Spinal Cord Injury |
| title_sort | bio c modified hyaluronic acid coated collagen tube implants enable functional recovery after complete spinal cord injury |
| topic | Bio-C spinal cord injury (SCI) neurotrophic anti-inflammatory ADC |
| url | https://www.mdpi.com/1999-4923/14/3/596 |
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