Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation

Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation

Introduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased mortality and morbidity. The Exchange Protein directly Activated by cAMP (EPAC), has been implicated in pro-arrhythmic signaling pathways in the atria, but the underlying mechanism...

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Main Authors: Bastien Guillot, Arthur Boileve, Richard Walton, Alexandre Harfoush, Caroline Conte, Yannis Sainte-Marie, Sabine Charron, Olivier Bernus, Alice Recalde, Laurent Sallé, Fabien Brette, Frank Lezoualc’h
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Physiology
Subjects:
EPAC
atrial fibrillation
optical mapping
cardiomyocytes
action potential
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1120336/full

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