Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea
The correlation between statin use and the development of gallstone disease remains controversial. Existing data, primarily based on Caucasian populations, are biased, thus necessitating validation studies involving Asian cohorts. We conducted a nested case–control study using data from the Korean N...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/4/536 |
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| author | Mi Jung Kwon Jung Woo Lee Ho Suk Kang Hyun Lim Eun Soo Kim Nan Young Kim Hyo Geun Choi Min-Jeong Kim |
| author_facet | Mi Jung Kwon Jung Woo Lee Ho Suk Kang Hyun Lim Eun Soo Kim Nan Young Kim Hyo Geun Choi Min-Jeong Kim |
| author_sort | Mi Jung Kwon |
| collection | DOAJ |
| description | The correlation between statin use and the development of gallstone disease remains controversial. Existing data, primarily based on Caucasian populations, are biased, thus necessitating validation studies involving Asian cohorts. We conducted a nested case–control study using data from the Korean National Health Insurance Service Health Screening Cohort (2002–2019) to determine the likelihood of gallstone disease according to periods of previous statin use and type of statin. Among the 514,866 participants, 22,636 diagnosed with gallstones at ≥2 clinic visits (using the International Classification of Diseases, 10th revision, code K80) were matched 1:4 to 90,544 controls for age, sex, income, and residential area, and their statin prescription history for 2 years prior to the index date was examined. Propensity-score-weighted odds ratios (ORs) for gallstone disease were calculated using conditional logistic regression. Long-term use (>545 days) of any statin or lipophilic statins was associated with lower odds of incident gallstones (OR = 0.91, 95% confidence interval [CI] = 0.86–0.96, <i>p</i> < 0.001 and OR = 0.88, 95% CI = 0.83–0.93, <i>p</i> < 0.001, respectively) after adjusting for confounders. Short-term use (180–545 days) of any statin or hydrophilic statins was not statistically related to incident gallstones. In summary, prior statin medication, particularly long-term lipophilic statin use, may confer a preventive advantage against gallstone disease. |
| first_indexed | 2024-03-11T04:39:07Z |
| format | Article |
| id | doaj.art-3532b115c6bc442088088782130f82d0 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T04:39:07Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-3532b115c6bc442088088782130f82d02023-11-17T20:50:19ZengMDPI AGPharmaceuticals1424-82472023-04-0116453610.3390/ph16040536Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in KoreaMi Jung Kwon0Jung Woo Lee1Ho Suk Kang2Hyun Lim3Eun Soo Kim4Nan Young Kim5Hyo Geun Choi6Min-Jeong Kim7Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Radiology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaHallym Institute of Translational Genomics and Bioinformatics, Hallym University Medical Center, Anyang 14068, Republic of KoreaSuseo Seoul ENT Clinic and MD Analytics, 10, Bamgogae-ro 1-gil, Gangnam-gu, Seoul 06349, Republic of KoreaDepartment of Radiology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaThe correlation between statin use and the development of gallstone disease remains controversial. Existing data, primarily based on Caucasian populations, are biased, thus necessitating validation studies involving Asian cohorts. We conducted a nested case–control study using data from the Korean National Health Insurance Service Health Screening Cohort (2002–2019) to determine the likelihood of gallstone disease according to periods of previous statin use and type of statin. Among the 514,866 participants, 22,636 diagnosed with gallstones at ≥2 clinic visits (using the International Classification of Diseases, 10th revision, code K80) were matched 1:4 to 90,544 controls for age, sex, income, and residential area, and their statin prescription history for 2 years prior to the index date was examined. Propensity-score-weighted odds ratios (ORs) for gallstone disease were calculated using conditional logistic regression. Long-term use (>545 days) of any statin or lipophilic statins was associated with lower odds of incident gallstones (OR = 0.91, 95% confidence interval [CI] = 0.86–0.96, <i>p</i> < 0.001 and OR = 0.88, 95% CI = 0.83–0.93, <i>p</i> < 0.001, respectively) after adjusting for confounders. Short-term use (180–545 days) of any statin or hydrophilic statins was not statistically related to incident gallstones. In summary, prior statin medication, particularly long-term lipophilic statin use, may confer a preventive advantage against gallstone disease.https://www.mdpi.com/1424-8247/16/4/536gallstone diseasestatinslipophilic statinhydrophilic statinnested case—control study |
| spellingShingle | Mi Jung Kwon Jung Woo Lee Ho Suk Kang Hyun Lim Eun Soo Kim Nan Young Kim Hyo Geun Choi Min-Jeong Kim Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea Pharmaceuticals gallstone disease statins lipophilic statin hydrophilic statin nested case—control study |
| title | Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea |
| title_full | Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea |
| title_fullStr | Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea |
| title_full_unstemmed | Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea |
| title_short | Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea |
| title_sort | association between gallstone disease and statin use a nested case control study in korea |
| topic | gallstone disease statins lipophilic statin hydrophilic statin nested case—control study |
| url | https://www.mdpi.com/1424-8247/16/4/536 |
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