Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders
Celiac Disease (CD) is an immune-mediated and gluten-related disorder whose prevalence is higher in children affected with other autoimmune disorders, including diabetes mellitus type 1, autoimmune thyroiditis, and others. As regards Juvenile Idiopathic Arthritis (JIA) and other pediatric rheumatic...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/4/1089 |
| _version_ | 1797479101630513152 |
|---|---|
| author | Dimitri Poddighe Micol Romano Kuanysh Dossybayeva Diyora Abdukhakimova Dinara Galiyeva Erkan Demirkaya |
| author_facet | Dimitri Poddighe Micol Romano Kuanysh Dossybayeva Diyora Abdukhakimova Dinara Galiyeva Erkan Demirkaya |
| author_sort | Dimitri Poddighe |
| collection | DOAJ |
| description | Celiac Disease (CD) is an immune-mediated and gluten-related disorder whose prevalence is higher in children affected with other autoimmune disorders, including diabetes mellitus type 1, autoimmune thyroiditis, and others. As regards Juvenile Idiopathic Arthritis (JIA) and other pediatric rheumatic disorders, there is no clear recommendation for CD serological screening. In this review, we analyze all the available clinical studies investigating CD among children with JIA (and other rheumatic diseases), in order to provide objective data to better understand the necessity of CD serological screening during the follow-up. Based on the present literature review and analysis, >2.5% patients with JIA were diagnosed with CD; however, the CD prevalence in JIA patients may be even higher (>3–3.5%) due to several study limitations that could have underestimated CD diagnosis to a variable extent. Therefore, serological screening for CD in children affected with JIA could be recommended due to the increased CD prevalence in these patients (compared to the general pediatric population), and because these JIA patients diagnosed with CD were mostly asymptomatic. However, further research is needed to establish a cost-effective approach in terms of CD screening frequency and modalities during the follow-up for JIA patients. Conversely, at the moment, there is no evidence supporting a periodical CD screening in children affected with other rheumatic diseases (including pediatric systemic lupus erythematosus, juvenile dermatomyositis, and systemic sclerosis). |
| first_indexed | 2024-03-09T21:40:55Z |
| format | Article |
| id | doaj.art-3533c95c24124628a8cd183744b229a4 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T21:40:55Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3533c95c24124628a8cd183744b229a42023-11-23T20:31:28ZengMDPI AGJournal of Clinical Medicine2077-03832022-02-01114108910.3390/jcm11041089Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic DisordersDimitri Poddighe0Micol Romano1Kuanysh Dossybayeva2Diyora Abdukhakimova3Dinara Galiyeva4Erkan Demirkaya5Department of Medicine, Nazarbayev University School of Medicine (NUSOM), Nur-Sultan 010000, KazakhstanDivision of Pediatric Rheumatology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5W9, CanadaDepartment of Medicine, Nazarbayev University School of Medicine (NUSOM), Nur-Sultan 010000, KazakhstanDepartment of Medicine, Nazarbayev University School of Medicine (NUSOM), Nur-Sultan 010000, KazakhstanDepartment of Medicine, Nazarbayev University School of Medicine (NUSOM), Nur-Sultan 010000, KazakhstanDivision of Pediatric Rheumatology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5W9, CanadaCeliac Disease (CD) is an immune-mediated and gluten-related disorder whose prevalence is higher in children affected with other autoimmune disorders, including diabetes mellitus type 1, autoimmune thyroiditis, and others. As regards Juvenile Idiopathic Arthritis (JIA) and other pediatric rheumatic disorders, there is no clear recommendation for CD serological screening. In this review, we analyze all the available clinical studies investigating CD among children with JIA (and other rheumatic diseases), in order to provide objective data to better understand the necessity of CD serological screening during the follow-up. Based on the present literature review and analysis, >2.5% patients with JIA were diagnosed with CD; however, the CD prevalence in JIA patients may be even higher (>3–3.5%) due to several study limitations that could have underestimated CD diagnosis to a variable extent. Therefore, serological screening for CD in children affected with JIA could be recommended due to the increased CD prevalence in these patients (compared to the general pediatric population), and because these JIA patients diagnosed with CD were mostly asymptomatic. However, further research is needed to establish a cost-effective approach in terms of CD screening frequency and modalities during the follow-up for JIA patients. Conversely, at the moment, there is no evidence supporting a periodical CD screening in children affected with other rheumatic diseases (including pediatric systemic lupus erythematosus, juvenile dermatomyositis, and systemic sclerosis).https://www.mdpi.com/2077-0383/11/4/1089celiac diseasejuvenile idiopathic arthritispediatric systemic lupus erythematosusjuvenile dermatomyositissystemic sclerodermascreening |
| spellingShingle | Dimitri Poddighe Micol Romano Kuanysh Dossybayeva Diyora Abdukhakimova Dinara Galiyeva Erkan Demirkaya Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders Journal of Clinical Medicine celiac disease juvenile idiopathic arthritis pediatric systemic lupus erythematosus juvenile dermatomyositis systemic scleroderma screening |
| title | Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders |
| title_full | Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders |
| title_fullStr | Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders |
| title_full_unstemmed | Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders |
| title_short | Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders |
| title_sort | celiac disease in juvenile idiopathic arthritis and other pediatric rheumatic disorders |
| topic | celiac disease juvenile idiopathic arthritis pediatric systemic lupus erythematosus juvenile dermatomyositis systemic scleroderma screening |
| url | https://www.mdpi.com/2077-0383/11/4/1089 |
| work_keys_str_mv | AT dimitripoddighe celiacdiseaseinjuvenileidiopathicarthritisandotherpediatricrheumaticdisorders AT micolromano celiacdiseaseinjuvenileidiopathicarthritisandotherpediatricrheumaticdisorders AT kuanyshdossybayeva celiacdiseaseinjuvenileidiopathicarthritisandotherpediatricrheumaticdisorders AT diyoraabdukhakimova celiacdiseaseinjuvenileidiopathicarthritisandotherpediatricrheumaticdisorders AT dinaragaliyeva celiacdiseaseinjuvenileidiopathicarthritisandotherpediatricrheumaticdisorders AT erkandemirkaya celiacdiseaseinjuvenileidiopathicarthritisandotherpediatricrheumaticdisorders |