ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning
In mice, reactivation of neurons that express cFos during fear conditioning induces a behavioural response. Here the authors show that cFos expression in mouse dentate gyrus shifts every day to different neurons, even during highly consistent spatial navigation, and suggest this clock-like selection...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33947-w |
| _version_ | 1811257189432557568 |
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| author | Paul J. Lamothe-Molina Andreas Franzelin Lennart Beck Dong Li Lea Auksutat Tim Fieblinger Laura Laprell Joachim Alhbeck Christine E. Gee Matthias Kneussel Andreas K. Engel Claus C. Hilgetag Fabio Morellini Thomas G. Oertner |
| author_facet | Paul J. Lamothe-Molina Andreas Franzelin Lennart Beck Dong Li Lea Auksutat Tim Fieblinger Laura Laprell Joachim Alhbeck Christine E. Gee Matthias Kneussel Andreas K. Engel Claus C. Hilgetag Fabio Morellini Thomas G. Oertner |
| author_sort | Paul J. Lamothe-Molina |
| collection | DOAJ |
| description | In mice, reactivation of neurons that express cFos during fear conditioning induces a behavioural response. Here the authors show that cFos expression in mouse dentate gyrus shifts every day to different neurons, even during highly consistent spatial navigation, and suggest this clock-like selection mechanism may aid the encoding of episodic memories. |
| first_indexed | 2024-04-12T17:53:33Z |
| format | Article |
| id | doaj.art-3533e982510d493eb9e861a533fcd010 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T17:53:33Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3533e982510d493eb9e861a533fcd0102022-12-22T03:22:26ZengNature PortfolioNature Communications2041-17232022-10-0113111610.1038/s41467-022-33947-wΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learningPaul J. Lamothe-Molina0Andreas Franzelin1Lennart Beck2Dong Li3Lea Auksutat4Tim Fieblinger5Laura Laprell6Joachim Alhbeck7Christine E. Gee8Matthias Kneussel9Andreas K. Engel10Claus C. Hilgetag11Fabio Morellini12Thomas G. Oertner13Institute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-EppendorfInstitute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-EppendorfInstitute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-EppendorfInstitute of Computational Neuroscience, University Medical Center Hamburg-EppendorfResearch Group Behavioral Biology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-EppendorfInstitute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-EppendorfInstitute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-EppendorfDepartment of Neurophysiology and Pathophysiology, Center for Experimental Medicine (ZEM), University Medical Center Hamburg-EppendorfInstitute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-EppendorfInstitute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-EppendorfDepartment of Neurophysiology and Pathophysiology, Center for Experimental Medicine (ZEM), University Medical Center Hamburg-EppendorfInstitute of Computational Neuroscience, University Medical Center Hamburg-EppendorfResearch Group Behavioral Biology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-EppendorfInstitute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-EppendorfIn mice, reactivation of neurons that express cFos during fear conditioning induces a behavioural response. Here the authors show that cFos expression in mouse dentate gyrus shifts every day to different neurons, even during highly consistent spatial navigation, and suggest this clock-like selection mechanism may aid the encoding of episodic memories.https://doi.org/10.1038/s41467-022-33947-w |
| spellingShingle | Paul J. Lamothe-Molina Andreas Franzelin Lennart Beck Dong Li Lea Auksutat Tim Fieblinger Laura Laprell Joachim Alhbeck Christine E. Gee Matthias Kneussel Andreas K. Engel Claus C. Hilgetag Fabio Morellini Thomas G. Oertner ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning Nature Communications |
| title | ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning |
| title_full | ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning |
| title_fullStr | ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning |
| title_full_unstemmed | ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning |
| title_short | ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning |
| title_sort | δfosb accumulation in hippocampal granule cells drives cfos pattern separation during spatial learning |
| url | https://doi.org/10.1038/s41467-022-33947-w |
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