Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature review
Brain abscess originates from a localized cerebritis area of brain parenchyma, remaining a refractory infectious disease in the central nervous system. Causative pathogens can be wide-ranging, including bacteria, fungi, or parasites; thus, precise pathogen identification and individualized antimicro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1248493/full |
| _version_ | 1797502632139423744 |
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| author | Zuoxin Zhang Jing Liu Linxi Su Weiwei Huang Yuchun Pei Guohao Huang Lin Yang Shengqing Lv Jinbo Yin Guolong Liu |
| author_facet | Zuoxin Zhang Jing Liu Linxi Su Weiwei Huang Yuchun Pei Guohao Huang Lin Yang Shengqing Lv Jinbo Yin Guolong Liu |
| author_sort | Zuoxin Zhang |
| collection | DOAJ |
| description | Brain abscess originates from a localized cerebritis area of brain parenchyma, remaining a refractory infectious disease in the central nervous system. Causative pathogens can be wide-ranging, including bacteria, fungi, or parasites; thus, precise pathogen identification and individualized antimicrobial therapy determine patients’ outcomes. Here, we report two cases where both patients only presented with limb dysfunction, but without symptoms, signs, or biological evidence of infection. Samples were obtained through brain stereoscopic surgeries and microbial identifications were performed to confirm the infection of Fusobacterium nucleatum. Further appropriate treatments were given, and the patients recovered well. Patient 1 was a 73-year-old male with a 20-day history of left-sided limbs weakness. A brain MRI showed a space-occupying lesion with a heterogeneously ring-enhancement character in the right frontal lobe. This patient underwent puncture biopsy of the lesion with robot-assisted guidance to confirm a brain abscess. Empirical antibiotic therapy was immediately given until the pathogen was identified as Fusobacterium nucleatum; thus, he received specific antibiotic therapy with metronidazole and recovered well after treatment. Patient 2 was a 22-year-old female with heart disease history who complained of right-sided limb weakness for nine days. A brain MRI showed a circular enhanced lesion with a thin capsule wall and surrounding edema in the left frontal lobe. This patient underwent puncture drainage of the lesion with robot-assisted guidance and a brain abscess was confirmed. Empirical antibiotic therapy was given until the pathogen was identified as Fusobacterium nucleatum and then she also received metronidazole treatment. Her symptoms recovered and the lesion disappeared after 1 month. Hence, we reviewed the diagnosis and treatment of cryptogenic brain abscess caused by Fusobacterium nucleatum and highlight that precise neurosurgical interventions and identification of causative pathogens are crucial for the management of brain abscess. |
| first_indexed | 2024-03-10T03:37:52Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-10T03:37:52Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-3534bb3ccff146ab91f8f18310c2090a2023-11-23T09:25:10ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-11-011710.3389/fnins.2023.12484931248493Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature reviewZuoxin Zhang0Jing Liu1Linxi Su2Weiwei Huang3Yuchun Pei4Guohao Huang5Lin Yang6Shengqing Lv7Jinbo Yin8Guolong Liu9Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Internal Medicine, Army 953 Hospital, Shigatse Branch of Xinqiao Hospital, Third Military Medical University (Army Medical University), Shigatse, ChinaDepartment of Pathology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Clinical Laboratory, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Neurosurgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaBrain abscess originates from a localized cerebritis area of brain parenchyma, remaining a refractory infectious disease in the central nervous system. Causative pathogens can be wide-ranging, including bacteria, fungi, or parasites; thus, precise pathogen identification and individualized antimicrobial therapy determine patients’ outcomes. Here, we report two cases where both patients only presented with limb dysfunction, but without symptoms, signs, or biological evidence of infection. Samples were obtained through brain stereoscopic surgeries and microbial identifications were performed to confirm the infection of Fusobacterium nucleatum. Further appropriate treatments were given, and the patients recovered well. Patient 1 was a 73-year-old male with a 20-day history of left-sided limbs weakness. A brain MRI showed a space-occupying lesion with a heterogeneously ring-enhancement character in the right frontal lobe. This patient underwent puncture biopsy of the lesion with robot-assisted guidance to confirm a brain abscess. Empirical antibiotic therapy was immediately given until the pathogen was identified as Fusobacterium nucleatum; thus, he received specific antibiotic therapy with metronidazole and recovered well after treatment. Patient 2 was a 22-year-old female with heart disease history who complained of right-sided limb weakness for nine days. A brain MRI showed a circular enhanced lesion with a thin capsule wall and surrounding edema in the left frontal lobe. This patient underwent puncture drainage of the lesion with robot-assisted guidance and a brain abscess was confirmed. Empirical antibiotic therapy was given until the pathogen was identified as Fusobacterium nucleatum and then she also received metronidazole treatment. Her symptoms recovered and the lesion disappeared after 1 month. Hence, we reviewed the diagnosis and treatment of cryptogenic brain abscess caused by Fusobacterium nucleatum and highlight that precise neurosurgical interventions and identification of causative pathogens are crucial for the management of brain abscess.https://www.frontiersin.org/articles/10.3389/fnins.2023.1248493/fullcryptogenic brain abscessFusobacterium nucleatumdiagnosisminimally invasivetreatmentlimb dysfunction |
| spellingShingle | Zuoxin Zhang Jing Liu Linxi Su Weiwei Huang Yuchun Pei Guohao Huang Lin Yang Shengqing Lv Jinbo Yin Guolong Liu Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature review Frontiers in Neuroscience cryptogenic brain abscess Fusobacterium nucleatum diagnosis minimally invasive treatment limb dysfunction |
| title | Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature review |
| title_full | Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature review |
| title_fullStr | Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature review |
| title_full_unstemmed | Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature review |
| title_short | Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature review |
| title_sort | case report two case reports of cryptogenic brain abscess caused by fusobacterium nucleatum and literature review |
| topic | cryptogenic brain abscess Fusobacterium nucleatum diagnosis minimally invasive treatment limb dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1248493/full |
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