DC-SIGN Increases Japanese Encephalitis Virus Infection
Japanese Encephalitis virus (JEV) is a mosquito borne flavivirus that infects macrophages, monocytes and dendritic cells (DCs) during in vivo replication. The C-type lectins DC-SIGN and DC-SIGNR have been reported to act as cell attachment factors for diverse array of pathogens. In this study, the e...
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| Format: | Article |
| Language: | English |
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University of Agriculture, Faisalabad
2013-11-01
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| Series: | Pakistan Veterinary Journal |
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| Online Access: | http://pvj.com.pk/pdf-files/33_4/408-412.pdf |
| _version_ | 1818510368135184384 |
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| author | Yang Yang, Ali Zohaib, Gong Chen, Jing Ye and Shengbo Cao* |
| author_facet | Yang Yang, Ali Zohaib, Gong Chen, Jing Ye and Shengbo Cao* |
| author_sort | Yang Yang, Ali Zohaib, Gong Chen, Jing Ye and Shengbo Cao* |
| collection | DOAJ |
| description | Japanese Encephalitis virus (JEV) is a mosquito borne flavivirus that infects macrophages, monocytes and dendritic cells (DCs) during in vivo replication. The C-type lectins DC-SIGN and DC-SIGNR have been reported to act as cell attachment factors for diverse array of pathogens. In this study, the effect of these lectins on JEV infection was investigated after the generation of 293T-SIGN (R) cell lines expressing DC-SIGN and DC-SIGNR receptors. It was observed that only DC-SIGN but not the DC-SIGNR can act as a viral attachment factor in case of JEV infection. The infection to cells expressing DC-SIGN was efficiently blocked by anti-DC-SIGN and mannan molecules. It was also found that insect derived JEV has higher affinity for DC-SIGN as compare to the mammalian derived JEV. These results initially suggest that DC-SIGN could act as viral attachment receptors (VAR) for JEV and enhance JEV infection. |
| first_indexed | 2024-12-10T22:58:17Z |
| format | Article |
| id | doaj.art-3534f86a323a4620a3e56e73b396222f |
| institution | Directory Open Access Journal |
| issn | 0253-8318 2074-7764 |
| language | English |
| last_indexed | 2024-12-10T22:58:17Z |
| publishDate | 2013-11-01 |
| publisher | University of Agriculture, Faisalabad |
| record_format | Article |
| series | Pakistan Veterinary Journal |
| spelling | doaj.art-3534f86a323a4620a3e56e73b396222f2022-12-22T01:30:13ZengUniversity of Agriculture, FaisalabadPakistan Veterinary Journal0253-83182074-77642013-11-01334408412DC-SIGN Increases Japanese Encephalitis Virus InfectionYang Yang, Ali Zohaib, Gong Chen, Jing Ye and Shengbo Cao*Japanese Encephalitis virus (JEV) is a mosquito borne flavivirus that infects macrophages, monocytes and dendritic cells (DCs) during in vivo replication. The C-type lectins DC-SIGN and DC-SIGNR have been reported to act as cell attachment factors for diverse array of pathogens. In this study, the effect of these lectins on JEV infection was investigated after the generation of 293T-SIGN (R) cell lines expressing DC-SIGN and DC-SIGNR receptors. It was observed that only DC-SIGN but not the DC-SIGNR can act as a viral attachment factor in case of JEV infection. The infection to cells expressing DC-SIGN was efficiently blocked by anti-DC-SIGN and mannan molecules. It was also found that insect derived JEV has higher affinity for DC-SIGN as compare to the mammalian derived JEV. These results initially suggest that DC-SIGN could act as viral attachment receptors (VAR) for JEV and enhance JEV infection.http://pvj.com.pk/pdf-files/33_4/408-412.pdfDC-SIGNDC-SIGNRJapanese Encephalitis virus |
| spellingShingle | Yang Yang, Ali Zohaib, Gong Chen, Jing Ye and Shengbo Cao* DC-SIGN Increases Japanese Encephalitis Virus Infection Pakistan Veterinary Journal DC-SIGN DC-SIGNR Japanese Encephalitis virus |
| title | DC-SIGN Increases Japanese Encephalitis Virus Infection |
| title_full | DC-SIGN Increases Japanese Encephalitis Virus Infection |
| title_fullStr | DC-SIGN Increases Japanese Encephalitis Virus Infection |
| title_full_unstemmed | DC-SIGN Increases Japanese Encephalitis Virus Infection |
| title_short | DC-SIGN Increases Japanese Encephalitis Virus Infection |
| title_sort | dc sign increases japanese encephalitis virus infection |
| topic | DC-SIGN DC-SIGNR Japanese Encephalitis virus |
| url | http://pvj.com.pk/pdf-files/33_4/408-412.pdf |
| work_keys_str_mv | AT yangyangalizohaibgongchenjingyeandshengbocao dcsignincreasesjapaneseencephalitisvirusinfection |