Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment
Alzheimer’s disease (AD) is a progressive age-related brain disorder that slowly destroys memory, with no cure for AD currently available. Plants from the Lamiaceae have been used traditionally for improving memory. Nineteen Mentha taxa were screened for in vitro antioxidant and acetyl- (AChE) and b...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-06-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617301445 |
| _version_ | 1818667026615369728 |
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| author | Doaa M. Hanafy Paul D. Prenzler Geoffrey E. Burrows Danielle Ryan Sharon Nielsen Salma A. El Sawi Taha S. El Alfy Enas H. Abdelrahman Hassan K. Obied |
| author_facet | Doaa M. Hanafy Paul D. Prenzler Geoffrey E. Burrows Danielle Ryan Sharon Nielsen Salma A. El Sawi Taha S. El Alfy Enas H. Abdelrahman Hassan K. Obied |
| author_sort | Doaa M. Hanafy |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a progressive age-related brain disorder that slowly destroys memory, with no cure for AD currently available. Plants from the Lamiaceae have been used traditionally for improving memory. Nineteen Mentha taxa were screened for in vitro antioxidant and acetyl- (AChE) and butyryl-cholinesterase (BuChE) and histone deacetylase (HDAC) inhibition activities. Total phenolic content was assessed, together with chromatographic determination of the phenolic composition. Two species, Mentha diemenica and M. requienii, were investigated for the first time. Mints showed strong antioxidant and moderate AChE and BuChE inhibition activities. Mint extracts exhibited good HDAC inhibition activity which was strongly correlated to their biophenol content. Apigenin-7-O-β-D-diglucuronide, chicoric acid and isosakuranetin were tentatively identified as new compounds in Mentha. Our results suggest that mints provide a substantial basis for future research into AD treatment. Furthermore, we highlight that biophenol composition and bioactivity can vary according to several factors within a single taxon. |
| first_indexed | 2024-12-17T06:13:53Z |
| format | Article |
| id | doaj.art-35350eaeb0dd41d384bf952854c88489 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T06:13:53Z |
| publishDate | 2017-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-35350eaeb0dd41d384bf952854c884892022-12-21T22:00:33ZengElsevierJournal of Functional Foods1756-46462017-06-0133345362Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatmentDoaa M. Hanafy0Paul D. Prenzler1Geoffrey E. Burrows2Danielle Ryan3Sharon Nielsen4Salma A. El Sawi5Taha S. El Alfy6Enas H. Abdelrahman7Hassan K. Obied8School of Biomedical Sciences, Locked Bag 588, Charles Sturt University, Wagga Wagga, NSW 2678, Australia; Department of Pharmacognosy, National Research Centre, Dokki, 12622 Cairo, EgyptSchool of Agricultural & Wine Sciences, Locked Bag 588, Charles Sturt University, Wagga Wagga, NSW 2678, Australia; Corresponding author.School of Agricultural & Wine Sciences, Locked Bag 588, Charles Sturt University, Wagga Wagga, NSW 2678, AustraliaSchool of Agricultural & Wine Sciences, Locked Bag 588, Charles Sturt University, Wagga Wagga, NSW 2678, AustraliaQuantitative Consulting Unit, Research Office, Locked Bag 588, Charles Sturt University, Wagga Wagga, NSW 2678, AustraliaDepartment of Pharmacognosy, National Research Centre, Dokki, 12622 Cairo, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El Ainy Street, 11562 Cairo, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El Ainy Street, 11562 Cairo, EgyptSchool of Biomedical Sciences, Locked Bag 588, Charles Sturt University, Wagga Wagga, NSW 2678, AustraliaAlzheimer’s disease (AD) is a progressive age-related brain disorder that slowly destroys memory, with no cure for AD currently available. Plants from the Lamiaceae have been used traditionally for improving memory. Nineteen Mentha taxa were screened for in vitro antioxidant and acetyl- (AChE) and butyryl-cholinesterase (BuChE) and histone deacetylase (HDAC) inhibition activities. Total phenolic content was assessed, together with chromatographic determination of the phenolic composition. Two species, Mentha diemenica and M. requienii, were investigated for the first time. Mints showed strong antioxidant and moderate AChE and BuChE inhibition activities. Mint extracts exhibited good HDAC inhibition activity which was strongly correlated to their biophenol content. Apigenin-7-O-β-D-diglucuronide, chicoric acid and isosakuranetin were tentatively identified as new compounds in Mentha. Our results suggest that mints provide a substantial basis for future research into AD treatment. Furthermore, we highlight that biophenol composition and bioactivity can vary according to several factors within a single taxon.http://www.sciencedirect.com/science/article/pii/S1756464617301445CholinesteraseLamiaceaeMenthaMentha diemenicaMentha requieniiPolyphenol |
| spellingShingle | Doaa M. Hanafy Paul D. Prenzler Geoffrey E. Burrows Danielle Ryan Sharon Nielsen Salma A. El Sawi Taha S. El Alfy Enas H. Abdelrahman Hassan K. Obied Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment Journal of Functional Foods Cholinesterase Lamiaceae Mentha Mentha diemenica Mentha requienii Polyphenol |
| title | Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment |
| title_full | Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment |
| title_fullStr | Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment |
| title_full_unstemmed | Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment |
| title_short | Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment |
| title_sort | biophenols of mints antioxidant acetylcholinesterase butyrylcholinesterase and histone deacetylase inhibition activities targeting alzheimer s disease treatment |
| topic | Cholinesterase Lamiaceae Mentha Mentha diemenica Mentha requienii Polyphenol |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617301445 |
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