A Rapid PCR-Free Next-Generation Sequencing Method for the Detection of Copy Number Variations in Prenatal Samples

A Rapid PCR-Free Next-Generation Sequencing Method for the Detection of Copy Number Variations in Prenatal Samples

Next-generation sequencing (NGS) is emerging as a new method for the detection of clinically significant copy number variants (CNVs). In this study, we developed and validated rapid CNV-sequencing (rCNV-seq) for clinical application in prenatal diagnosis. Low-pass whole-genome sequencing was perform...

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Bibliographic Details
Main Authors: Xiya Zhou, Xiangbin Chen, Yulin Jiang, Qingwei Qi, Na Hao, Chengkun Liu, Mengnan Xu, David S. Cram, Juntao Liu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Life
Subjects:
chromosome disorders
copy number variation (CNV)
PCR-free libraries
rapid copy number variation sequencing (rCNV-seq)
Online Access:https://www.mdpi.com/2075-1729/11/2/98

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