Genotoxicity biomarkers for monitoring occupational exposure to antineoplastic drugs
Context: The Institute of Oncology and Radiobiology (INOR) is the leading institution for the diagnosis, treatment and follow-up of cancer in Cuba. The main methods used in cancer treatment are surgery, radiotherapy and chemotherapy. The last one involves the handling of hazardous substances, such a...
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| Format: | Article |
| Language: | English |
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GarVal Editorial Ltda.
2016-06-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | http://jppres.com/jppres/pdf/vol4/jppres16.107_4.3.122.pdf |
| _version_ | 1819049482194518016 |
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| author | Hilda M. Rodríguez-Montero Esther Argote-Pelegrino Adriana Díaz-Curbelo Elizabeth B. Cuétara-Lugo |
| author_facet | Hilda M. Rodríguez-Montero Esther Argote-Pelegrino Adriana Díaz-Curbelo Elizabeth B. Cuétara-Lugo |
| author_sort | Hilda M. Rodríguez-Montero |
| collection | DOAJ |
| description | Context: The Institute of Oncology and Radiobiology (INOR) is the leading institution for the diagnosis, treatment and follow-up of cancer in Cuba. The main methods used in cancer treatment are surgery, radiotherapy and chemotherapy. The last one involves the handling of hazardous substances, such as cytostatics, which implies a health risk to persons occupationally exposed to it. There are two sites where a considerable among of cytostatic is handled (Ambulatory Chemotherapy Room (ACR) and the Central Unit of Cytostatic Mixture Preparation (CUCM)). Genotoxicity biomarkers of exposure and effects have been widely used to detect occupational environment hazards.
Aims: To evaluate genotoxicity biomarkers indicative of exposure and effects to cytostatics.
Methods: In this study were tested samples taken from the surfaces of biological safety cabinets located in the Central Unit of Cytostatic Mixture using SOS – Chromotest. We also evaluated samples of oral mucosa exfoliated cells from exposed and control subjects, by micronucleus test.
Results: All subjects were exposed and subjects who administered the mixes in the institution had an increased of DNA damage in comparison with the pharmaceutical staff that prepared it and wear the primary protection barriers properly.
Conclusions: These results underline the efficiency of genotoxicological biomarkers in detecting the exposure levels and the deleterious effect of cytostatics on occupationally exposed personal. |
| first_indexed | 2024-12-21T11:32:51Z |
| format | Article |
| id | doaj.art-3535c5c6cc6c46d0879fbab2db9f8d82 |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-12-21T11:32:51Z |
| publishDate | 2016-06-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-3535c5c6cc6c46d0879fbab2db9f8d822022-12-21T19:05:30ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502016-06-0143122133Genotoxicity biomarkers for monitoring occupational exposure to antineoplastic drugsHilda M. Rodríguez-Montero0Esther Argote-Pelegrino1Adriana Díaz-Curbelo2Elizabeth B. Cuétara-Lugo3Institute of Oncology and Radiobiology of Cuba. 29 y F, Vedado CP 10400. La Habana. Cuba.Cuban Society of Veterinary. Paseo e/ 23 y 25, Vedado CP 10400. La Habana. Cuba.Centro of Applied Technologies and Nuclear Development. 30 y 5ta Avenida. Miramar. Playa. La Habana. Cuba.Institute of Oncology and Radiobiology of Cuba. 29 y F, Vedado CP 10400. La Habana. Cuba.Context: The Institute of Oncology and Radiobiology (INOR) is the leading institution for the diagnosis, treatment and follow-up of cancer in Cuba. The main methods used in cancer treatment are surgery, radiotherapy and chemotherapy. The last one involves the handling of hazardous substances, such as cytostatics, which implies a health risk to persons occupationally exposed to it. There are two sites where a considerable among of cytostatic is handled (Ambulatory Chemotherapy Room (ACR) and the Central Unit of Cytostatic Mixture Preparation (CUCM)). Genotoxicity biomarkers of exposure and effects have been widely used to detect occupational environment hazards. Aims: To evaluate genotoxicity biomarkers indicative of exposure and effects to cytostatics. Methods: In this study were tested samples taken from the surfaces of biological safety cabinets located in the Central Unit of Cytostatic Mixture using SOS – Chromotest. We also evaluated samples of oral mucosa exfoliated cells from exposed and control subjects, by micronucleus test. Results: All subjects were exposed and subjects who administered the mixes in the institution had an increased of DNA damage in comparison with the pharmaceutical staff that prepared it and wear the primary protection barriers properly. Conclusions: These results underline the efficiency of genotoxicological biomarkers in detecting the exposure levels and the deleterious effect of cytostatics on occupationally exposed personal.http://jppres.com/jppres/pdf/vol4/jppres16.107_4.3.122.pdfBiosafetycytostatic handlingmicronucleus testoccupational healthSOS Chromotest |
| spellingShingle | Hilda M. Rodríguez-Montero Esther Argote-Pelegrino Adriana Díaz-Curbelo Elizabeth B. Cuétara-Lugo Genotoxicity biomarkers for monitoring occupational exposure to antineoplastic drugs Journal of Pharmacy & Pharmacognosy Research Biosafety cytostatic handling micronucleus test occupational health SOS Chromotest |
| title | Genotoxicity biomarkers for monitoring occupational exposure to antineoplastic drugs |
| title_full | Genotoxicity biomarkers for monitoring occupational exposure to antineoplastic drugs |
| title_fullStr | Genotoxicity biomarkers for monitoring occupational exposure to antineoplastic drugs |
| title_full_unstemmed | Genotoxicity biomarkers for monitoring occupational exposure to antineoplastic drugs |
| title_short | Genotoxicity biomarkers for monitoring occupational exposure to antineoplastic drugs |
| title_sort | genotoxicity biomarkers for monitoring occupational exposure to antineoplastic drugs |
| topic | Biosafety cytostatic handling micronucleus test occupational health SOS Chromotest |
| url | http://jppres.com/jppres/pdf/vol4/jppres16.107_4.3.122.pdf |
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