High concentration formulation developability approaches and considerations

High concentration formulation developability approaches and considerations

ABSTRACTThe growing need for biologics to be administered subcutaneously and ocularly, coupled with certain indications requiring high doses, has resulted in an increase in drug substance (DS) and drug product (DP) protein concentrations. With this increase, more emphasis must be placed on identifyi...

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Bibliographic Details
Main Authors: Jonathan Zarzar, Tarik Khan, Maniraj Bhagawati, Benjamin Weiche, Jasmin Sydow-Andersen, Alavattam Sreedhara
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Aggregation
developability
high concentration formulations
in-silico
physical instability
subcutaneous administration
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2211185

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