The effect of agmatine on trichothecene type B and zearalenone production in Fusarium graminearum, F. culmorum and F. poae
Agmatine and other putrescines are known for being strong inducers of deoxynivalenol (DON) production in Fusarium graminearum. Other important species produce DON and/or other trichothecene type B toxins (3 acetylated DON, 15 acetylated DON, Fusarenon-X, Nivalenol), such as F. culmorum and F. poae....
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PeerJ Inc.
2016-02-01
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| Online Access: | https://peerj.com/articles/1672.pdf |
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| author | Matias Pasquali Emmanuelle Cocco Cédric Guignard Lucien Hoffmann |
| author_facet | Matias Pasquali Emmanuelle Cocco Cédric Guignard Lucien Hoffmann |
| author_sort | Matias Pasquali |
| collection | DOAJ |
| description | Agmatine and other putrescines are known for being strong inducers of deoxynivalenol (DON) production in Fusarium graminearum. Other important species produce DON and/or other trichothecene type B toxins (3 acetylated DON, 15 acetylated DON, Fusarenon-X, Nivalenol), such as F. culmorum and F. poae. In order to verify whether the mechanism of the regulation of trichothecene type B induction by agmatine is shared by different species of Fusarium, we tested the hypothesis on 19 strains belonging to 3 Fusarium species (F. graminearum, F. culmorum, F. poae) with diverse genetic chemotypes (3ADON, 15ADON, NIV) by measuring trichothecene B toxins such as DON, NIV, Fusarenon-X, 3ADON and 15ADON. Moreover, we tested whether other toxins like zearalenone were also boosted by agmatine. The trichothecene type B boosting effect was observed in the majority of strains (13 out of 19) in all the three species. Representative strains from all three genetic chemotypes were able to boost toxin production after agmatine treatment. We identified the non-responding strains to the agmatine stimulus, which may contribute to deciphering the regulatory mechanisms that link toxin production to agmatine (and, more generally, polyamines). |
| first_indexed | 2024-03-09T06:54:56Z |
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| id | doaj.art-35382e6f5baf442298cc2adb145a5126 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:54:56Z |
| publishDate | 2016-02-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-35382e6f5baf442298cc2adb145a51262023-12-03T10:07:17ZengPeerJ Inc.PeerJ2167-83592016-02-014e167210.7717/peerj.1672The effect of agmatine on trichothecene type B and zearalenone production in Fusarium graminearum, F. culmorum and F. poaeMatias Pasquali0Emmanuelle Cocco1Cédric Guignard2Lucien Hoffmann3Department of Environmental Research and Innovation, Luxembourg Institute of Science and Technology (LIST), Belvaux, LuxembourgDepartment of Environmental Research and Innovation, Luxembourg Institute of Science and Technology (LIST), Belvaux, LuxembourgDepartment of Environmental Research and Innovation, Luxembourg Institute of Science and Technology (LIST), Belvaux, LuxembourgDepartment of Environmental Research and Innovation, Luxembourg Institute of Science and Technology (LIST), Belvaux, LuxembourgAgmatine and other putrescines are known for being strong inducers of deoxynivalenol (DON) production in Fusarium graminearum. Other important species produce DON and/or other trichothecene type B toxins (3 acetylated DON, 15 acetylated DON, Fusarenon-X, Nivalenol), such as F. culmorum and F. poae. In order to verify whether the mechanism of the regulation of trichothecene type B induction by agmatine is shared by different species of Fusarium, we tested the hypothesis on 19 strains belonging to 3 Fusarium species (F. graminearum, F. culmorum, F. poae) with diverse genetic chemotypes (3ADON, 15ADON, NIV) by measuring trichothecene B toxins such as DON, NIV, Fusarenon-X, 3ADON and 15ADON. Moreover, we tested whether other toxins like zearalenone were also boosted by agmatine. The trichothecene type B boosting effect was observed in the majority of strains (13 out of 19) in all the three species. Representative strains from all three genetic chemotypes were able to boost toxin production after agmatine treatment. We identified the non-responding strains to the agmatine stimulus, which may contribute to deciphering the regulatory mechanisms that link toxin production to agmatine (and, more generally, polyamines).https://peerj.com/articles/1672.pdfZearalenoneFusarenon-XDeoxynivalenolNivalenol3-acetylated deoxynivalenol15-acetylaed deoxynivalenol |
| spellingShingle | Matias Pasquali Emmanuelle Cocco Cédric Guignard Lucien Hoffmann The effect of agmatine on trichothecene type B and zearalenone production in Fusarium graminearum, F. culmorum and F. poae PeerJ Zearalenone Fusarenon-X Deoxynivalenol Nivalenol 3-acetylated deoxynivalenol 15-acetylaed deoxynivalenol |
| title | The effect of agmatine on trichothecene type B and zearalenone production in Fusarium graminearum, F. culmorum and F. poae |
| title_full | The effect of agmatine on trichothecene type B and zearalenone production in Fusarium graminearum, F. culmorum and F. poae |
| title_fullStr | The effect of agmatine on trichothecene type B and zearalenone production in Fusarium graminearum, F. culmorum and F. poae |
| title_full_unstemmed | The effect of agmatine on trichothecene type B and zearalenone production in Fusarium graminearum, F. culmorum and F. poae |
| title_short | The effect of agmatine on trichothecene type B and zearalenone production in Fusarium graminearum, F. culmorum and F. poae |
| title_sort | effect of agmatine on trichothecene type b and zearalenone production in fusarium graminearum f culmorum and f poae |
| topic | Zearalenone Fusarenon-X Deoxynivalenol Nivalenol 3-acetylated deoxynivalenol 15-acetylaed deoxynivalenol |
| url | https://peerj.com/articles/1672.pdf |
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