Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated Nanoparticles
Recently, biomimetic nanoparticles, especially cell membrane-cloaked nanoparticles, have attracted increasing attention in biomedical applications, including antitumor therapy, detoxification, and immune modulation, by imitating the structure and the function of biological systems such as long circu...
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| Format: | Article |
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MDPI AG
2019-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/8/881 |
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| author | Haichun Li Kai Jin Man Luo Xuejun Wang Xiaowen Zhu Xianping Liu Ting Jiang Qin Zhang Sheng Wang Zhiqing Pang |
| author_facet | Haichun Li Kai Jin Man Luo Xuejun Wang Xiaowen Zhu Xianping Liu Ting Jiang Qin Zhang Sheng Wang Zhiqing Pang |
| author_sort | Haichun Li |
| collection | DOAJ |
| description | Recently, biomimetic nanoparticles, especially cell membrane-cloaked nanoparticles, have attracted increasing attention in biomedical applications, including antitumor therapy, detoxification, and immune modulation, by imitating the structure and the function of biological systems such as long circulation life in the blood. However, the circulation time of cell membrane-cloaked nanoparticles is far less than that of the original cells, greatly limiting their biomedical applications, while the underlying reasons are seldom demonstrated. In this study, the influence of particle size on the circulation and the biodistribution of red blood cell membrane-coated nanoparticles (RBC-NPs) as model biomimetic nanoparticles were investigated. Differently sized RBC-NPs (80, 120, 160, and 200 nm) were prepared by fusing RBC membranes on poly(lactic-co-glycolic acid) nanoparticles. It was shown that the particle size did not change the cellular uptake of these biomimetic nanoparticles by macrophage cells in vitro and their immunogenic responses in vivo. However, their circulation life in vivo decreased with the particle size, while their accumulation in the liver increased with the particle size, which might be related to their size-dependent filtration through hepatic sinusoids. These findings will provide experimental evidence for the design and the optimization of biomimetic nanoparticles. |
| first_indexed | 2024-03-12T07:48:29Z |
| format | Article |
| id | doaj.art-35397ace88b04532bb6fbd7b8bd5b680 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:48:29Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-35397ace88b04532bb6fbd7b8bd5b6802023-09-02T20:48:05ZengMDPI AGCells2073-44092019-08-018888110.3390/cells8080881cells8080881Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated NanoparticlesHaichun Li0Kai Jin1Man Luo2Xuejun Wang3Xiaowen Zhu4Xianping Liu5Ting Jiang6Qin Zhang7Sheng Wang8Zhiqing Pang9Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaSchool of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, 826 Zhangheng Road, Shanghai 201203, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin 150040, ChinaSchool of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, 826 Zhangheng Road, Shanghai 201203, ChinaSchool of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, 826 Zhangheng Road, Shanghai 201203, ChinaSchool of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, 826 Zhangheng Road, Shanghai 201203, ChinaSchool of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, 826 Zhangheng Road, Shanghai 201203, ChinaDepartment of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, ChinaDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaSchool of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, 826 Zhangheng Road, Shanghai 201203, ChinaRecently, biomimetic nanoparticles, especially cell membrane-cloaked nanoparticles, have attracted increasing attention in biomedical applications, including antitumor therapy, detoxification, and immune modulation, by imitating the structure and the function of biological systems such as long circulation life in the blood. However, the circulation time of cell membrane-cloaked nanoparticles is far less than that of the original cells, greatly limiting their biomedical applications, while the underlying reasons are seldom demonstrated. In this study, the influence of particle size on the circulation and the biodistribution of red blood cell membrane-coated nanoparticles (RBC-NPs) as model biomimetic nanoparticles were investigated. Differently sized RBC-NPs (80, 120, 160, and 200 nm) were prepared by fusing RBC membranes on poly(lactic-co-glycolic acid) nanoparticles. It was shown that the particle size did not change the cellular uptake of these biomimetic nanoparticles by macrophage cells in vitro and their immunogenic responses in vivo. However, their circulation life in vivo decreased with the particle size, while their accumulation in the liver increased with the particle size, which might be related to their size-dependent filtration through hepatic sinusoids. These findings will provide experimental evidence for the design and the optimization of biomimetic nanoparticles.https://www.mdpi.com/2073-4409/8/8/881biomimetic nanoparticlescell membrane-coated nanoparticlesparticle sizecirculationbiodistribution |
| spellingShingle | Haichun Li Kai Jin Man Luo Xuejun Wang Xiaowen Zhu Xianping Liu Ting Jiang Qin Zhang Sheng Wang Zhiqing Pang Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated Nanoparticles Cells biomimetic nanoparticles cell membrane-coated nanoparticles particle size circulation biodistribution |
| title | Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated Nanoparticles |
| title_full | Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated Nanoparticles |
| title_fullStr | Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated Nanoparticles |
| title_full_unstemmed | Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated Nanoparticles |
| title_short | Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated Nanoparticles |
| title_sort | size dependency of circulation and biodistribution of biomimetic nanoparticles red blood cell membrane coated nanoparticles |
| topic | biomimetic nanoparticles cell membrane-coated nanoparticles particle size circulation biodistribution |
| url | https://www.mdpi.com/2073-4409/8/8/881 |
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