Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China
Ischemic stroke is caused by an interruption in the flow of blood to the brain and a risk factor for death and disability. Recent genome-wide association studies have identified more than 40 common sequence variants associated with ischemic stroke. However, the results are not always the same in pop...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2017-11-01
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| Series: | Вавиловский журнал генетики и селекции |
| Subjects: | |
| Online Access: | https://vavilov.elpub.ru/jour/article/view/1144 |
| _version_ | 1826550197440741376 |
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| author | Q. Wu H. Wu Yu. L. Orlov G. Gegentana W. Huo A. O. Bragin N. Wu S. Suyalatu F. Zhao J. Zhao L. E. Tabikhanova M. Chen H. Bai |
| author_facet | Q. Wu H. Wu Yu. L. Orlov G. Gegentana W. Huo A. O. Bragin N. Wu S. Suyalatu F. Zhao J. Zhao L. E. Tabikhanova M. Chen H. Bai |
| author_sort | Q. Wu |
| collection | DOAJ |
| description | Ischemic stroke is caused by an interruption in the flow of blood to the brain and a risk factor for death and disability. Recent genome-wide association studies have identified more than 40 common sequence variants associated with ischemic stroke. However, the results are not always the same in populations with different genetic backgrounds. In the present study, we evaluated a hypothesis that a North Asian population living in a geographic area with unusually harsh environmental conditions would develop unique genetic risks. We investigated the candidate genes for ischemic stroke and risk factors in a Chinese Mongolian population which has not been explored previously. A total of 167 stroke cases and 176 controls were included in the study. Genotyping was performed by amplicon sequencing. The association was detected with single nucleotide polymorphisms (SNPs) located within genes NINJ2 (rs12425791) and ALDH2 (rs2238151) as well as intergenic rs9536591 were significantly associated with ischemic stroke, of which SNP rs12425791 of the NINJ2 gene was the strongest association. ALDH2 gene encodes mitochondrial aldehyde dehydrogenase, involved in the oxidative pathway of alcohol metabolism. Sex, age, body mass index and high blood pressure might be the risk factors. The current work also demonstrated genetic heterogeneity exists between Chinese and other populations. Our study provided the new insights into the genetic basis and environmental factors of ischemic stroke in Mongolian population. |
| first_indexed | 2024-03-07T16:06:56Z |
| format | Article |
| id | doaj.art-3539f1f1e0e6415988faee7ed7d3c8f2 |
| institution | Directory Open Access Journal |
| issn | 2500-3259 |
| language | English |
| last_indexed | 2025-03-14T06:33:30Z |
| publishDate | 2017-11-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj.art-3539f1f1e0e6415988faee7ed7d3c8f22025-03-05T07:59:22ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592017-11-0121558158710.18699/VJ17.275652Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in ChinaQ. Wu0H. Wu1Yu. L. Orlov2G. Gegentana3W. Huo4A. O. Bragin5N. Wu6S. Suyalatu7F. Zhao8J. Zhao9L. E. Tabikhanova10M. Chen11H. Bai12Inner Mongolia University for the NationalitiesInner Mongolia University for the NationalitiesInstitute of Cytology and Genetics SB RAS; Novosibirsk State UniversityInner Mongolia University for the NationalitiesInner Mongolia University for the NationalitiesInstitute of Cytology and Genetics SB RASInner Mongolia University for the Nationalities; Northern Virginia Community CollegeInner Mongolia University for the NationalitiesInner Mongolia University for the NationalitiesInner Mongolia University for the NationalitiesInstitute of Cytology and Genetics SB RASZhejiang UniversityInner Mongolia University for the NationalitiesIschemic stroke is caused by an interruption in the flow of blood to the brain and a risk factor for death and disability. Recent genome-wide association studies have identified more than 40 common sequence variants associated with ischemic stroke. However, the results are not always the same in populations with different genetic backgrounds. In the present study, we evaluated a hypothesis that a North Asian population living in a geographic area with unusually harsh environmental conditions would develop unique genetic risks. We investigated the candidate genes for ischemic stroke and risk factors in a Chinese Mongolian population which has not been explored previously. A total of 167 stroke cases and 176 controls were included in the study. Genotyping was performed by amplicon sequencing. The association was detected with single nucleotide polymorphisms (SNPs) located within genes NINJ2 (rs12425791) and ALDH2 (rs2238151) as well as intergenic rs9536591 were significantly associated with ischemic stroke, of which SNP rs12425791 of the NINJ2 gene was the strongest association. ALDH2 gene encodes mitochondrial aldehyde dehydrogenase, involved in the oxidative pathway of alcohol metabolism. Sex, age, body mass index and high blood pressure might be the risk factors. The current work also demonstrated genetic heterogeneity exists between Chinese and other populations. Our study provided the new insights into the genetic basis and environmental factors of ischemic stroke in Mongolian population.https://vavilov.elpub.ru/jour/article/view/1144population geneticshuman genomesnpschinese mongolian populationischemic stroke |
| spellingShingle | Q. Wu H. Wu Yu. L. Orlov G. Gegentana W. Huo A. O. Bragin N. Wu S. Suyalatu F. Zhao J. Zhao L. E. Tabikhanova M. Chen H. Bai Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China Вавиловский журнал генетики и селекции population genetics human genome snps chinese mongolian population ischemic stroke |
| title | Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China |
| title_full | Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China |
| title_fullStr | Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China |
| title_full_unstemmed | Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China |
| title_short | Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China |
| title_sort | genetic polymorphisms and related risk factors of ischemic stroke in a mongolian population in china |
| topic | population genetics human genome snps chinese mongolian population ischemic stroke |
| url | https://vavilov.elpub.ru/jour/article/view/1144 |
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