High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients
Abstract Background Pentatrichomonas hominis is a flagellated protozoan that inhabits the large intestine of humans. Although several protozoans have been proposed to have a role in cancer progression, little is known about the epidemiology of P. hominis infection in cancer patients. Methods To dete...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-08-01
|
| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13071-019-3684-4 |
| _version_ | 1818249346775252992 |
|---|---|
| author | Nan Zhang Hongbo Zhang Yanhui Yu Pengtao Gong Jianhua Li Ziyi Li Ting Li Zhanjie Cong Chunying Tian Xiaofeng Liu Xiuyan Yu Xichen Zhang |
| author_facet | Nan Zhang Hongbo Zhang Yanhui Yu Pengtao Gong Jianhua Li Ziyi Li Ting Li Zhanjie Cong Chunying Tian Xiaofeng Liu Xiuyan Yu Xichen Zhang |
| author_sort | Nan Zhang |
| collection | DOAJ |
| description | Abstract Background Pentatrichomonas hominis is a flagellated protozoan that inhabits the large intestine of humans. Although several protozoans have been proposed to have a role in cancer progression, little is known about the epidemiology of P. hominis infection in cancer patients. Methods To determine the prevalence of P. hominis in patients with digestive system malignancies, we collected 195 and 142 fecal samples from gastrointestinal cancer patients and residents without any complaints related to the digestive system, respectively. Each sample was detected for the presence of P. hominis by nested PCR amplifying the internal transcribed spacer (ITS) region and partial 18S rRNA gene. Results A significantly higher prevalence of P. hominis was found in cancer patients than that in the control population (41.54 vs 9.15%, χ 2 = 42.84, df = 1, P < 0.001), resulting in a 6.75-fold risk of gastrointestinal cancers (OR: 6.75, 95% CI: 3.55–12.83, P < 0.001). The highest prevalence of P. hominis infection was detected in small intestine cancer patients (60%, OR: 14.88, 95% CI: 0.82–4.58, P = 0.009) followed by liver (57.14%, χ 2 = 10.82, df = 1, P = 0.001) and stomach cancer patients (45.1%, χ 2 = 31.95, df = 1, P < 0.001). In addition, phylogenetic analysis provided some evidence supporting that human P. hominis infection might derive from animal sources. Conclusions To our knowledge, this study is the first report presenting the high association between P. hominis and gastrointestinal cancers. Nevertheless, whether there is any possible pathological role of P. hominis infection in cancer patients needs to be further elucidated. |
| first_indexed | 2024-12-12T15:35:02Z |
| format | Article |
| id | doaj.art-353d36fee1e044b4adeb35d187359ade |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-12T15:35:02Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-353d36fee1e044b4adeb35d187359ade2022-12-22T00:20:01ZengBMCParasites & Vectors1756-33052019-08-011211910.1186/s13071-019-3684-4High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patientsNan Zhang0Hongbo Zhang1Yanhui Yu2Pengtao Gong3Jianhua Li4Ziyi Li5Ting Li6Zhanjie Cong7Chunying Tian8Xiaofeng Liu9Xiuyan Yu10Xichen Zhang11The First Hospital, Key Laboratory of Zoonosis Research by Ministry of Education, Institute of Zoonosis, Jilin UniversityKey Laboratory of Zoonosis Research by Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin UniversityClinical Lab, The Second Hospital, Jilin UniversityKey Laboratory of Zoonosis Research by Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin UniversityKey Laboratory of Zoonosis Research by Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin UniversityThe First Hospital, Key Laboratory of Zoonosis Research by Ministry of Education, Institute of Zoonosis, Jilin UniversityJilin Cancer HospitalJilin Cancer HospitalJilin Cancer HospitalJilin Cancer HospitalJilin Cancer HospitalKey Laboratory of Zoonosis Research by Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin UniversityAbstract Background Pentatrichomonas hominis is a flagellated protozoan that inhabits the large intestine of humans. Although several protozoans have been proposed to have a role in cancer progression, little is known about the epidemiology of P. hominis infection in cancer patients. Methods To determine the prevalence of P. hominis in patients with digestive system malignancies, we collected 195 and 142 fecal samples from gastrointestinal cancer patients and residents without any complaints related to the digestive system, respectively. Each sample was detected for the presence of P. hominis by nested PCR amplifying the internal transcribed spacer (ITS) region and partial 18S rRNA gene. Results A significantly higher prevalence of P. hominis was found in cancer patients than that in the control population (41.54 vs 9.15%, χ 2 = 42.84, df = 1, P < 0.001), resulting in a 6.75-fold risk of gastrointestinal cancers (OR: 6.75, 95% CI: 3.55–12.83, P < 0.001). The highest prevalence of P. hominis infection was detected in small intestine cancer patients (60%, OR: 14.88, 95% CI: 0.82–4.58, P = 0.009) followed by liver (57.14%, χ 2 = 10.82, df = 1, P = 0.001) and stomach cancer patients (45.1%, χ 2 = 31.95, df = 1, P < 0.001). In addition, phylogenetic analysis provided some evidence supporting that human P. hominis infection might derive from animal sources. Conclusions To our knowledge, this study is the first report presenting the high association between P. hominis and gastrointestinal cancers. Nevertheless, whether there is any possible pathological role of P. hominis infection in cancer patients needs to be further elucidated.http://link.springer.com/article/10.1186/s13071-019-3684-4Pentatrichomonas hominisGastrointestinal cancerColorectal cancerStomach cancerEpidemiology |
| spellingShingle | Nan Zhang Hongbo Zhang Yanhui Yu Pengtao Gong Jianhua Li Ziyi Li Ting Li Zhanjie Cong Chunying Tian Xiaofeng Liu Xiuyan Yu Xichen Zhang High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients Parasites & Vectors Pentatrichomonas hominis Gastrointestinal cancer Colorectal cancer Stomach cancer Epidemiology |
| title | High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients |
| title_full | High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients |
| title_fullStr | High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients |
| title_full_unstemmed | High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients |
| title_short | High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients |
| title_sort | high prevalence of pentatrichomonas hominis infection in gastrointestinal cancer patients |
| topic | Pentatrichomonas hominis Gastrointestinal cancer Colorectal cancer Stomach cancer Epidemiology |
| url | http://link.springer.com/article/10.1186/s13071-019-3684-4 |
| work_keys_str_mv | AT nanzhang highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT hongbozhang highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT yanhuiyu highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT pengtaogong highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT jianhuali highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT ziyili highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT tingli highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT zhanjiecong highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT chunyingtian highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT xiaofengliu highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT xiuyanyu highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients AT xichenzhang highprevalenceofpentatrichomonashominisinfectioningastrointestinalcancerpatients |