Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice
Wheat embryo globulin (WEG) has been proven to possess multiple biological activities, including antioxidative properties, immunomodulatory, and so on. Aged mouse model were established by subcutaneous injection of D-galactose (D-gal), and the effects of WEG on learning, memory, and antioxidant capa...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-07-01
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| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002312 |
| _version_ | 1797697526891020288 |
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| author | Aimei Liaoa Xing Lyu Jiarui Ma Yinchen Hou Ming Hui Na Liu Yi Zhao Yixiang Cui Jihong Huang |
| author_facet | Aimei Liaoa Xing Lyu Jiarui Ma Yinchen Hou Ming Hui Na Liu Yi Zhao Yixiang Cui Jihong Huang |
| author_sort | Aimei Liaoa |
| collection | DOAJ |
| description | Wheat embryo globulin (WEG) has been proven to possess multiple biological activities, including antioxidative properties, immunomodulatory, and so on. Aged mouse model were established by subcutaneous injection of D-galactose (D-gal), and the effects of WEG on learning, memory, and antioxidant capacity in aging mice were explored through behavioural tests and antioxidant enzyme activities determination. Compared with the Model group, WEG improved the percentage of the platform quadrant, increased the number of crossing platforms, and enhanced the identification indexs. WEG also increased total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities in the liver and brains of aging mice, and reduced malondialdehyde (MDA) content. Pathological observations indicated that WEG protected against damage to brain in D-gal-induced aging mice. These results effectively revealed that WEG not only improved the abilities of learning and memory, and the cognitive impairment, but also delayed the aging process of the D-gal-induced mice. |
| first_indexed | 2024-03-12T03:41:28Z |
| format | Article |
| id | doaj.art-353e50b2456349bcad6baa2f43451cea |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T03:41:28Z |
| publishDate | 2023-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-353e50b2456349bcad6baa2f43451cea2023-09-03T13:02:28ZengTsinghua University PressFood Science and Human Wellness2213-45302023-07-0112413001308Multi-protective effects of wheat embryo globulin on D-gal-induced aging miceAimei Liaoa0Xing Lyu1Jiarui Ma2Yinchen Hou3Ming Hui4Na Liu5Yi Zhao6Yixiang Cui7Jihong Huang8Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Luoyang 471000, ChinaCollege of Biological Engineering, Henan University of Technology, Luoyang 471000, China; Zhengzhou Synear Food Co., Ltd., Zhengzhou 450000, ChinaCollege of Biological Engineering, Henan University of Technology, Luoyang 471000, ChinaHenan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Luoyang 471000, ChinaCollege of Biological Engineering, Henan University of Technology, Luoyang 471000, ChinaCollege of Biological Engineering, Henan University of Technology, Luoyang 471000, ChinaCollege of Biological Engineering, Henan University of Technology, Luoyang 471000, ChinaCollege of Biological Engineering, Henan University of Technology, Luoyang 471000, ChinaCollege of Biological Engineering, Henan University of Technology, Luoyang 471000, China; Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat, Luoyang 471000, China; School of Food and Pharmacy, Xuchang University, Xuchang 461000, China; Corresponding author at: College of Biological Engineering, Henan University of Technology, Zhengzhou 450000, ChinaWheat embryo globulin (WEG) has been proven to possess multiple biological activities, including antioxidative properties, immunomodulatory, and so on. Aged mouse model were established by subcutaneous injection of D-galactose (D-gal), and the effects of WEG on learning, memory, and antioxidant capacity in aging mice were explored through behavioural tests and antioxidant enzyme activities determination. Compared with the Model group, WEG improved the percentage of the platform quadrant, increased the number of crossing platforms, and enhanced the identification indexs. WEG also increased total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities in the liver and brains of aging mice, and reduced malondialdehyde (MDA) content. Pathological observations indicated that WEG protected against damage to brain in D-gal-induced aging mice. These results effectively revealed that WEG not only improved the abilities of learning and memory, and the cognitive impairment, but also delayed the aging process of the D-gal-induced mice.http://www.sciencedirect.com/science/article/pii/S2213453022002312Wheat embryo globulinAntioxidant activityD-galactoseSuperoxide dismutaseGlutathione peroxidase |
| spellingShingle | Aimei Liaoa Xing Lyu Jiarui Ma Yinchen Hou Ming Hui Na Liu Yi Zhao Yixiang Cui Jihong Huang Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice Food Science and Human Wellness Wheat embryo globulin Antioxidant activity D-galactose Superoxide dismutase Glutathione peroxidase |
| title | Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice |
| title_full | Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice |
| title_fullStr | Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice |
| title_full_unstemmed | Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice |
| title_short | Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice |
| title_sort | multi protective effects of wheat embryo globulin on d gal induced aging mice |
| topic | Wheat embryo globulin Antioxidant activity D-galactose Superoxide dismutase Glutathione peroxidase |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002312 |
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