Desquamation in Kawasaki Disease
(1) Background: Desquamation is a common characteristic of Kawasaki disease (KD). In this study, we analyzed patients’ varying desquamation levels in their hands or feet, in correlation with clinical presentation, to assess the relationship. (2) Methods: We retrospectively reviewed children with KD....
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/5/317 |
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| author | Ling-Sai Chang Ken-Pen Weng Jia-Huei Yan Wan-Shan Lo Mindy Ming-Huey Guo Ying-Hsien Huang Ho-Chang Kuo |
| author_facet | Ling-Sai Chang Ken-Pen Weng Jia-Huei Yan Wan-Shan Lo Mindy Ming-Huey Guo Ying-Hsien Huang Ho-Chang Kuo |
| author_sort | Ling-Sai Chang |
| collection | DOAJ |
| description | (1) Background: Desquamation is a common characteristic of Kawasaki disease (KD). In this study, we analyzed patients’ varying desquamation levels in their hands or feet, in correlation with clinical presentation, to assess the relationship. (2) Methods: We retrospectively reviewed children with KD. We analyzed their age, laboratory data before intravenous immunoglobulin (IVIG) treatment and coronary artery abnormalities (CAA) based on the desquamation level of their hands and feet. We classified the desquamation level from 0 to 3 and defined high-grade desquamation as grade 2 and 3. (3) Results: We enrolled a total 112 patients in the study. We found the hands’ high-grade desquamation was positively associated with age and segmented neutrophil percentage (<i>p</i> = 0.047 and 0.029, respectively) but negatively associated with lymphocyte and monocyte percentage (<i>p</i> = 0.03 and 0.006, respectively). Meanwhile, the feet’s high-grade desquamation was positively associated with total white blood cell counts (<i>p</i> = 0.033). Furthermore, we found that high-grade hand desquamation had less probability of CAA formation compared with that of a low grade (7.1% vs. 40.8%, <i>p</i> = 0.016). (4) Conclusions: This report is the first to demonstrate that the desquamation level of hands or feet in KD is associated with different coronary artery abnormalities and laboratory findings. |
| first_indexed | 2024-03-10T12:06:30Z |
| format | Article |
| id | doaj.art-353fb9f837084f37939dcc708e79d749 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T12:06:30Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-353fb9f837084f37939dcc708e79d7492023-11-21T16:33:46ZengMDPI AGChildren2227-90672021-04-018531710.3390/children8050317Desquamation in Kawasaki DiseaseLing-Sai Chang0Ken-Pen Weng1Jia-Huei Yan2Wan-Shan Lo3Mindy Ming-Huey Guo4Ying-Hsien Huang5Ho-Chang Kuo6Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Da-Pei Road, Niaosong District, Kaohsiung 83301, TaiwanCongenital Structural Heart Disease Center, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Da-Pei Road, Niaosong District, Kaohsiung 83301, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Da-Pei Road, Niaosong District, Kaohsiung 83301, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Da-Pei Road, Niaosong District, Kaohsiung 83301, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Da-Pei Road, Niaosong District, Kaohsiung 83301, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123 Da-Pei Road, Niaosong District, Kaohsiung 83301, Taiwan(1) Background: Desquamation is a common characteristic of Kawasaki disease (KD). In this study, we analyzed patients’ varying desquamation levels in their hands or feet, in correlation with clinical presentation, to assess the relationship. (2) Methods: We retrospectively reviewed children with KD. We analyzed their age, laboratory data before intravenous immunoglobulin (IVIG) treatment and coronary artery abnormalities (CAA) based on the desquamation level of their hands and feet. We classified the desquamation level from 0 to 3 and defined high-grade desquamation as grade 2 and 3. (3) Results: We enrolled a total 112 patients in the study. We found the hands’ high-grade desquamation was positively associated with age and segmented neutrophil percentage (<i>p</i> = 0.047 and 0.029, respectively) but negatively associated with lymphocyte and monocyte percentage (<i>p</i> = 0.03 and 0.006, respectively). Meanwhile, the feet’s high-grade desquamation was positively associated with total white blood cell counts (<i>p</i> = 0.033). Furthermore, we found that high-grade hand desquamation had less probability of CAA formation compared with that of a low grade (7.1% vs. 40.8%, <i>p</i> = 0.016). (4) Conclusions: This report is the first to demonstrate that the desquamation level of hands or feet in KD is associated with different coronary artery abnormalities and laboratory findings.https://www.mdpi.com/2227-9067/8/5/317desquamationcoronary artery lesionKawasaki disease |
| spellingShingle | Ling-Sai Chang Ken-Pen Weng Jia-Huei Yan Wan-Shan Lo Mindy Ming-Huey Guo Ying-Hsien Huang Ho-Chang Kuo Desquamation in Kawasaki Disease Children desquamation coronary artery lesion Kawasaki disease |
| title | Desquamation in Kawasaki Disease |
| title_full | Desquamation in Kawasaki Disease |
| title_fullStr | Desquamation in Kawasaki Disease |
| title_full_unstemmed | Desquamation in Kawasaki Disease |
| title_short | Desquamation in Kawasaki Disease |
| title_sort | desquamation in kawasaki disease |
| topic | desquamation coronary artery lesion Kawasaki disease |
| url | https://www.mdpi.com/2227-9067/8/5/317 |
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