The Binding Landscape of Serum Antibodies: How Physical and Mathematical Concepts Can Advance Systems Immunology
Antibodies constitute a major component of serum on protein mass basis. We also know that the structural diversity of these antibodies exceeds that of all other proteins in the body and they react with an immense number of molecular targets. What we still cannot quantitatively describe is how antibo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Antibodies |
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| Online Access: | https://www.mdpi.com/2073-4468/11/3/43 |
| _version_ | 1827664037057396736 |
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| author | József Prechl Krisztián Papp Ágnes Kovács Tamás Pfeil |
| author_facet | József Prechl Krisztián Papp Ágnes Kovács Tamás Pfeil |
| author_sort | József Prechl |
| collection | DOAJ |
| description | Antibodies constitute a major component of serum on protein mass basis. We also know that the structural diversity of these antibodies exceeds that of all other proteins in the body and they react with an immense number of molecular targets. What we still cannot quantitatively describe is how antibody abundance is related to affinity, specificity, and cross reactivity. This ignorance has important practical consequences: we also do not have proper biochemical units for characterizing polyclonal serum antibody binding. The solution requires both a theoretical foundation, a physical model of the system, and technology for the experimental confirmation of theory. Here we argue that the quantitative characterization of interactions between serum antibodies and their targets requires systems-level physical chemistry approach and generates results that should help create maps of antibody binding landscape. |
| first_indexed | 2024-03-10T00:53:36Z |
| format | Article |
| id | doaj.art-35408d47246b490ea8829fb4eba50fa0 |
| institution | Directory Open Access Journal |
| issn | 2073-4468 |
| language | English |
| last_indexed | 2024-03-10T00:53:36Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibodies |
| spelling | doaj.art-35408d47246b490ea8829fb4eba50fa02023-11-23T14:46:01ZengMDPI AGAntibodies2073-44682022-06-011134310.3390/antib11030043The Binding Landscape of Serum Antibodies: How Physical and Mathematical Concepts Can Advance Systems ImmunologyJózsef Prechl0Krisztián Papp1Ágnes Kovács2Tamás Pfeil3R&D Laboratory, Diagnosticum Zrt, 1047 Budapest, HungaryR&D Laboratory, Diagnosticum Zrt, 1047 Budapest, HungaryDepartment of Applied Analysis and Computational Mathematics, Eötvös Loránd University, 1117 Budapest, HungaryDepartment of Applied Analysis and Computational Mathematics, Eötvös Loránd University, 1117 Budapest, HungaryAntibodies constitute a major component of serum on protein mass basis. We also know that the structural diversity of these antibodies exceeds that of all other proteins in the body and they react with an immense number of molecular targets. What we still cannot quantitatively describe is how antibody abundance is related to affinity, specificity, and cross reactivity. This ignorance has important practical consequences: we also do not have proper biochemical units for characterizing polyclonal serum antibody binding. The solution requires both a theoretical foundation, a physical model of the system, and technology for the experimental confirmation of theory. Here we argue that the quantitative characterization of interactions between serum antibodies and their targets requires systems-level physical chemistry approach and generates results that should help create maps of antibody binding landscape.https://www.mdpi.com/2073-4468/11/3/43antibodysystemchemical potentiallogistic functiondifferential equation |
| spellingShingle | József Prechl Krisztián Papp Ágnes Kovács Tamás Pfeil The Binding Landscape of Serum Antibodies: How Physical and Mathematical Concepts Can Advance Systems Immunology Antibodies antibody system chemical potential logistic function differential equation |
| title | The Binding Landscape of Serum Antibodies: How Physical and Mathematical Concepts Can Advance Systems Immunology |
| title_full | The Binding Landscape of Serum Antibodies: How Physical and Mathematical Concepts Can Advance Systems Immunology |
| title_fullStr | The Binding Landscape of Serum Antibodies: How Physical and Mathematical Concepts Can Advance Systems Immunology |
| title_full_unstemmed | The Binding Landscape of Serum Antibodies: How Physical and Mathematical Concepts Can Advance Systems Immunology |
| title_short | The Binding Landscape of Serum Antibodies: How Physical and Mathematical Concepts Can Advance Systems Immunology |
| title_sort | binding landscape of serum antibodies how physical and mathematical concepts can advance systems immunology |
| topic | antibody system chemical potential logistic function differential equation |
| url | https://www.mdpi.com/2073-4468/11/3/43 |
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