Neural effects of continuous theta-burst stimulation in macaque parietal neurons
Theta-burst transcranial magnetic stimulation (TBS) has become a standard non-invasive technique to induce offline changes in cortical excitability in human volunteers. Yet, TBS suffers from a high variability across subjects. A better knowledge about how TBS affects neural activity in vivo could un...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2022-09-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/65536 |
| _version_ | 1811181276707684352 |
|---|---|
| author | Maria C Romero Lara Merken Peter Janssen Marco Davare |
| author_facet | Maria C Romero Lara Merken Peter Janssen Marco Davare |
| author_sort | Maria C Romero |
| collection | DOAJ |
| description | Theta-burst transcranial magnetic stimulation (TBS) has become a standard non-invasive technique to induce offline changes in cortical excitability in human volunteers. Yet, TBS suffers from a high variability across subjects. A better knowledge about how TBS affects neural activity in vivo could uncover its mechanisms of action and ultimately allow its mainstream use in basic science and clinical applications. To address this issue, we applied continuous TBS (cTBS, 300 pulses) in awake behaving rhesus monkeys and quantified its after-effects on neuronal activity. Overall, we observed a pronounced, long-lasting, and highly reproducible reduction in neuronal excitability after cTBS in individual parietal neurons, with some neurons also exhibiting periods of hyperexcitability during the recovery phase. These results provide the first experimental evidence of the effects of cTBS on single neurons in awake behaving monkeys, shedding new light on the reasons underlying cTBS variability. |
| first_indexed | 2024-04-11T09:14:43Z |
| format | Article |
| id | doaj.art-35426627fb2c483a9526f5f1cae96762 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:14:43Z |
| publishDate | 2022-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-35426627fb2c483a9526f5f1cae967622022-12-22T04:32:23ZengeLife Sciences Publications LtdeLife2050-084X2022-09-011110.7554/eLife.65536Neural effects of continuous theta-burst stimulation in macaque parietal neuronsMaria C Romero0https://orcid.org/0000-0001-7758-2211Lara Merken1Peter Janssen2https://orcid.org/0000-0002-8463-5577Marco Davare3https://orcid.org/0000-0002-4670-0251Laboratorium voor Neuro- en Psychofysiologie, The Leuven Brain Institute, Leuven, BelgiumLaboratorium voor Neuro- en Psychofysiologie, The Leuven Brain Institute, Leuven, BelgiumLaboratorium voor Neuro- en Psychofysiologie, The Leuven Brain Institute, Leuven, BelgiumFaculty of Life Sciences and Medicine, King's College London, London, United KingdomTheta-burst transcranial magnetic stimulation (TBS) has become a standard non-invasive technique to induce offline changes in cortical excitability in human volunteers. Yet, TBS suffers from a high variability across subjects. A better knowledge about how TBS affects neural activity in vivo could uncover its mechanisms of action and ultimately allow its mainstream use in basic science and clinical applications. To address this issue, we applied continuous TBS (cTBS, 300 pulses) in awake behaving rhesus monkeys and quantified its after-effects on neuronal activity. Overall, we observed a pronounced, long-lasting, and highly reproducible reduction in neuronal excitability after cTBS in individual parietal neurons, with some neurons also exhibiting periods of hyperexcitability during the recovery phase. These results provide the first experimental evidence of the effects of cTBS on single neurons in awake behaving monkeys, shedding new light on the reasons underlying cTBS variability.https://elifesciences.org/articles/65536transcranial magnetic stimulationelectrophysiologyparietal |
| spellingShingle | Maria C Romero Lara Merken Peter Janssen Marco Davare Neural effects of continuous theta-burst stimulation in macaque parietal neurons eLife transcranial magnetic stimulation electrophysiology parietal |
| title | Neural effects of continuous theta-burst stimulation in macaque parietal neurons |
| title_full | Neural effects of continuous theta-burst stimulation in macaque parietal neurons |
| title_fullStr | Neural effects of continuous theta-burst stimulation in macaque parietal neurons |
| title_full_unstemmed | Neural effects of continuous theta-burst stimulation in macaque parietal neurons |
| title_short | Neural effects of continuous theta-burst stimulation in macaque parietal neurons |
| title_sort | neural effects of continuous theta burst stimulation in macaque parietal neurons |
| topic | transcranial magnetic stimulation electrophysiology parietal |
| url | https://elifesciences.org/articles/65536 |
| work_keys_str_mv | AT mariacromero neuraleffectsofcontinuousthetaburststimulationinmacaqueparietalneurons AT laramerken neuraleffectsofcontinuousthetaburststimulationinmacaqueparietalneurons AT peterjanssen neuraleffectsofcontinuousthetaburststimulationinmacaqueparietalneurons AT marcodavare neuraleffectsofcontinuousthetaburststimulationinmacaqueparietalneurons |