New-Onset Crohn’s Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn’s Disease
Patients with autoimmune conditions show a high expression of proinflammatory cytokines including interleukin (IL)-17. While IL-17 inhibitors have demonstrated efficacy in managing autoimmune disorders, rare instances of de novo or exacerbated inflammatory bowel disease (IBD) have been reported. The...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2023/1769290 |
| _version_ | 1797816585670361088 |
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| author | Anas Khouri Cesar Moreno Benjamin Niland |
| author_facet | Anas Khouri Cesar Moreno Benjamin Niland |
| author_sort | Anas Khouri |
| collection | DOAJ |
| description | Patients with autoimmune conditions show a high expression of proinflammatory cytokines including interleukin (IL)-17. While IL-17 inhibitors have demonstrated efficacy in managing autoimmune disorders, rare instances of de novo or exacerbated inflammatory bowel disease (IBD) have been reported. The factors that affect the onset and severity remain unclear. Here, we present a case of a 38-year-old female who developed manifestations of Crohn’s disease within 1 month of initiating secukinumab treatment for psoriatic arthritis, in addition to a review of the role of IL-17 in the pathophysiology of Crohn’s disease. |
| first_indexed | 2024-03-13T08:39:49Z |
| format | Article |
| id | doaj.art-3543311305f54ebbaf14863a4569869a |
| institution | Directory Open Access Journal |
| issn | 2090-6536 |
| language | English |
| last_indexed | 2024-03-13T08:39:49Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj.art-3543311305f54ebbaf14863a4569869a2023-05-30T12:28:37ZengHindawi LimitedCase Reports in Gastrointestinal Medicine2090-65362023-01-01202310.1155/2023/1769290New-Onset Crohn’s Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn’s DiseaseAnas Khouri0Cesar Moreno1Benjamin Niland2Department of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicinePatients with autoimmune conditions show a high expression of proinflammatory cytokines including interleukin (IL)-17. While IL-17 inhibitors have demonstrated efficacy in managing autoimmune disorders, rare instances of de novo or exacerbated inflammatory bowel disease (IBD) have been reported. The factors that affect the onset and severity remain unclear. Here, we present a case of a 38-year-old female who developed manifestations of Crohn’s disease within 1 month of initiating secukinumab treatment for psoriatic arthritis, in addition to a review of the role of IL-17 in the pathophysiology of Crohn’s disease.http://dx.doi.org/10.1155/2023/1769290 |
| spellingShingle | Anas Khouri Cesar Moreno Benjamin Niland New-Onset Crohn’s Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn’s Disease Case Reports in Gastrointestinal Medicine |
| title | New-Onset Crohn’s Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn’s Disease |
| title_full | New-Onset Crohn’s Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn’s Disease |
| title_fullStr | New-Onset Crohn’s Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn’s Disease |
| title_full_unstemmed | New-Onset Crohn’s Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn’s Disease |
| title_short | New-Onset Crohn’s Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn’s Disease |
| title_sort | new onset crohn s disease following initiation of secukinumab a case report and review of the role of il 17 in the pathogenesis of crohn s disease |
| url | http://dx.doi.org/10.1155/2023/1769290 |
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