Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer
Cancer continues to be one of the leading causes of death worldwide, and its incidence is on the rise. Although cancer diagnosis and therapy have advanced significantly in recent decades, it is still a challenge to achieve the accurate identification and localization of cancer and to complete tumor...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/8/1044 |
| _version_ | 1797432417004290048 |
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| author | Tian Wang Yingying Chen Bo Wang Xiaofan Gao Mingfu Wu |
| author_facet | Tian Wang Yingying Chen Bo Wang Xiaofan Gao Mingfu Wu |
| author_sort | Tian Wang |
| collection | DOAJ |
| description | Cancer continues to be one of the leading causes of death worldwide, and its incidence is on the rise. Although cancer diagnosis and therapy have advanced significantly in recent decades, it is still a challenge to achieve the accurate identification and localization of cancer and to complete tumor elimination with a maximum preservation of normal tissue. Recently, second near-infrared region (NIR-II, 1000–1700 nm) fluorescence has shown great application potential in cancer theranostics due to its inherent advantages, such as great penetration capacity, minimal tissue absorption and scattering, and low autofluorescence. With the development of fluorescence imaging systems and fluorescent probes, tumor detection, margin definition, and individualized therapy can be achieved quickly, enabling an increasingly accurate diagnosis and treatment of cancer. Herein, this review introduces the role of NIR-II fluorescence imaging in cancer diagnosis and summarizes the representative applications of NIR-II image-guided treatment in cancer therapy. Ultimately, we discuss the present challenges and future perspectives on fluorescence imaging in the field of cancer theranostics and put forward our opinions on how to improve the accuracy and efficiency of cancer diagnosis and therapeutics. |
| first_indexed | 2024-03-09T10:00:14Z |
| format | Article |
| id | doaj.art-35436cb80fc7455e95c5e083fae2c06d |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T10:00:14Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-35436cb80fc7455e95c5e083fae2c06d2023-12-01T23:28:48ZengMDPI AGBiomolecules2218-273X2022-07-01128104410.3390/biom12081044Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in CancerTian Wang0Yingying Chen1Bo Wang2Xiaofan Gao3Mingfu Wu4Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaCancer continues to be one of the leading causes of death worldwide, and its incidence is on the rise. Although cancer diagnosis and therapy have advanced significantly in recent decades, it is still a challenge to achieve the accurate identification and localization of cancer and to complete tumor elimination with a maximum preservation of normal tissue. Recently, second near-infrared region (NIR-II, 1000–1700 nm) fluorescence has shown great application potential in cancer theranostics due to its inherent advantages, such as great penetration capacity, minimal tissue absorption and scattering, and low autofluorescence. With the development of fluorescence imaging systems and fluorescent probes, tumor detection, margin definition, and individualized therapy can be achieved quickly, enabling an increasingly accurate diagnosis and treatment of cancer. Herein, this review introduces the role of NIR-II fluorescence imaging in cancer diagnosis and summarizes the representative applications of NIR-II image-guided treatment in cancer therapy. Ultimately, we discuss the present challenges and future perspectives on fluorescence imaging in the field of cancer theranostics and put forward our opinions on how to improve the accuracy and efficiency of cancer diagnosis and therapeutics.https://www.mdpi.com/2218-273X/12/8/1044cancersecond near-infrared (NIR-II) fluorescence imagingfluorescent probecancer theranosticscancer diagnosiscancer treatment |
| spellingShingle | Tian Wang Yingying Chen Bo Wang Xiaofan Gao Mingfu Wu Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer Biomolecules cancer second near-infrared (NIR-II) fluorescence imaging fluorescent probe cancer theranostics cancer diagnosis cancer treatment |
| title | Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer |
| title_full | Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer |
| title_fullStr | Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer |
| title_full_unstemmed | Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer |
| title_short | Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer |
| title_sort | recent progress in second near infrared nir ii fluorescence imaging in cancer |
| topic | cancer second near-infrared (NIR-II) fluorescence imaging fluorescent probe cancer theranostics cancer diagnosis cancer treatment |
| url | https://www.mdpi.com/2218-273X/12/8/1044 |
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