Hormonal regulation of menstrual function in patients of reproductive age with acromegaly
Background: The frequency of menstrual disorders in patients with acromegaly is 40–84% and are caused by three main reasons – the development of normal or hypogonadotropic hypogonadism due to hyperprolactinemia or a mass effect of the tumor and direct effects of GH and IGF-1 on t...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2018-12-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/10049 |
| _version_ | 1827121697090699264 |
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| author | Svetlana Yu. Vorotnikova Larisa K. Dzeranova Irina V. Stanoevich Ekaterina A. Pigarova Elena N. Andreeva Larisa V. Nikankina Valery P. Masenko |
| author_facet | Svetlana Yu. Vorotnikova Larisa K. Dzeranova Irina V. Stanoevich Ekaterina A. Pigarova Elena N. Andreeva Larisa V. Nikankina Valery P. Masenko |
| author_sort | Svetlana Yu. Vorotnikova |
| collection | DOAJ |
| description | Background: The frequency of menstrual disorders in patients with acromegaly is 40–84% and are caused by three main reasons – the development of normal or hypogonadotropic hypogonadism due to hyperprolactinemia or a mass effect of the tumor and direct effects of GH and IGF-1 on the reproductive system. Nevertheless the exact mechanisms of reproductive dysfunction are not clear now. Hypothalamic structures play significant role in the regulation of hypothalamic-pituitary-ovary axis, so it’s important to study key neuropeptides and evaluate their effects to the pathogenesis of ovarian dysfunction during excessive secretion of growth hormone. Aim: The aim of the work is to study the hormonal regulation of menstrual function in patients of reproductive age with acromegaly in the active stage of the disease. Material and methods: The study included patients with a confirmed diagnosis of acromegaly and healthy women, comparable in age and BMI. Blood serum samples were taken in the morning (8–9 hours) on an empty stomach for 3–5 days of the menstrual cycle or on any day with amenorrhea and frozen at -70°C. The hormonal study was carried out by an enzyme immunoassay, in the case of a kisspeptin, with the preliminary extraction of serum samples. Results: The study included 31 patients with acromegaly and 15 healthy women. Between groups there was a statistically significant decrease in levels of LH (p = 0.001), FSH (p = 0.09), inhibin B (p = 0.003), and kisspeptin (p = 0.00005). The frequency of hyperprolactinemia in the cohort of patients was 51.6%. During the correlation analysis, a negative dependence of kisspeptin on the levels of GH and IGF-1 was detected (r = -0.54, p = 0.002 and r = -0.63, p = 0.0002). Conclusions: The severity of the central depression of regulation of menstrual function in patients with acromegaly may be due to the degree of disease activity. |
| first_indexed | 2024-03-08T09:13:02Z |
| format | Article |
| id | doaj.art-3543c955d96643d092c9a14649efa97c |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2025-03-20T13:57:15Z |
| publishDate | 2018-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-3543c955d96643d092c9a14649efa97c2024-09-11T16:17:51ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242018-12-01154596410.14341/omet100498632Hormonal regulation of menstrual function in patients of reproductive age with acromegalySvetlana Yu. Vorotnikova0Larisa K. Dzeranova1Irina V. Stanoevich2Ekaterina A. Pigarova3Elena N. Andreeva4Larisa V. Nikankina5Valery P. Masenko6<p>Endocrinology research centre</p><p>Endocrinology research centre</p><p>Endocrinology research centre</p><p>Endocrinology research centre</p><p>Endocrinology research centre</p><p>Endocrinology research centre</p><p>National medical research center of cardiology</p>Background: The frequency of menstrual disorders in patients with acromegaly is 40–84% and are caused by three main reasons – the development of normal or hypogonadotropic hypogonadism due to hyperprolactinemia or a mass effect of the tumor and direct effects of GH and IGF-1 on the reproductive system. Nevertheless the exact mechanisms of reproductive dysfunction are not clear now. Hypothalamic structures play significant role in the regulation of hypothalamic-pituitary-ovary axis, so it’s important to study key neuropeptides and evaluate their effects to the pathogenesis of ovarian dysfunction during excessive secretion of growth hormone. Aim: The aim of the work is to study the hormonal regulation of menstrual function in patients of reproductive age with acromegaly in the active stage of the disease. Material and methods: The study included patients with a confirmed diagnosis of acromegaly and healthy women, comparable in age and BMI. Blood serum samples were taken in the morning (8–9 hours) on an empty stomach for 3–5 days of the menstrual cycle or on any day with amenorrhea and frozen at -70°C. The hormonal study was carried out by an enzyme immunoassay, in the case of a kisspeptin, with the preliminary extraction of serum samples. Results: The study included 31 patients with acromegaly and 15 healthy women. Between groups there was a statistically significant decrease in levels of LH (p = 0.001), FSH (p = 0.09), inhibin B (p = 0.003), and kisspeptin (p = 0.00005). The frequency of hyperprolactinemia in the cohort of patients was 51.6%. During the correlation analysis, a negative dependence of kisspeptin on the levels of GH and IGF-1 was detected (r = -0.54, p = 0.002 and r = -0.63, p = 0.0002). Conclusions: The severity of the central depression of regulation of menstrual function in patients with acromegaly may be due to the degree of disease activity.https://www.omet-endojournals.ru/jour/article/view/10049growth hormoneacromegalyreproductive systeminsulin-like growth factor-1kisspeptin |
| spellingShingle | Svetlana Yu. Vorotnikova Larisa K. Dzeranova Irina V. Stanoevich Ekaterina A. Pigarova Elena N. Andreeva Larisa V. Nikankina Valery P. Masenko Hormonal regulation of menstrual function in patients of reproductive age with acromegaly Ожирение и метаболизм growth hormone acromegaly reproductive system insulin-like growth factor-1 kisspeptin |
| title | Hormonal regulation of menstrual function in patients of reproductive age with acromegaly |
| title_full | Hormonal regulation of menstrual function in patients of reproductive age with acromegaly |
| title_fullStr | Hormonal regulation of menstrual function in patients of reproductive age with acromegaly |
| title_full_unstemmed | Hormonal regulation of menstrual function in patients of reproductive age with acromegaly |
| title_short | Hormonal regulation of menstrual function in patients of reproductive age with acromegaly |
| title_sort | hormonal regulation of menstrual function in patients of reproductive age with acromegaly |
| topic | growth hormone acromegaly reproductive system insulin-like growth factor-1 kisspeptin |
| url | https://www.omet-endojournals.ru/jour/article/view/10049 |
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