Spontaneous improvement of interstitial pneumonia with autoimmune features: A case report
Abstract Interstitial pneumonia with autoimmune features (IPAF) was proposed to describe patients with interstitial lung disease who do not meet the classification criteria for a defined connective tissue disease. Here, we report a spontaneous improvement case of IPAF. A 58‐year‐old man developed dr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-11-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.867 |
| _version_ | 1819114594107392000 |
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| author | Hirotsugu Ohkubo Akiko Nakano Kohei Fujita Yoshiyuki Ozawa Takayuki Murase Akio Niimi |
| author_facet | Hirotsugu Ohkubo Akiko Nakano Kohei Fujita Yoshiyuki Ozawa Takayuki Murase Akio Niimi |
| author_sort | Hirotsugu Ohkubo |
| collection | DOAJ |
| description | Abstract Interstitial pneumonia with autoimmune features (IPAF) was proposed to describe patients with interstitial lung disease who do not meet the classification criteria for a defined connective tissue disease. Here, we report a spontaneous improvement case of IPAF. A 58‐year‐old man developed dry cough and dyspnoea. Positive result was obtained for the anti‐centromere antibody. High‐resolution computed tomography (HRCT) showed reticular abnormalities and ground‐glass opacities. Cryobiopsy specimens revealed cellular non‐specific interstitial pneumonia. The patient displayed periungual erythema and nail fold bleeding, but no sclerosis. He did not meet the criteria for systemic scleroderma, but did meet those for IPAF. Because symptoms slightly improved, the patient declined immunosuppressive treatment. After 6 months, repeated HRCT showed an apparent reduction in the area of ground‐glass opacities. The forced vital capacity improved from 2.72 to 3.47 L and serum Krebs von den Lungen (KL)‐6 decreased from 1977 to 531 U/ml, and symptoms disappeared. |
| first_indexed | 2024-12-22T04:47:46Z |
| format | Article |
| id | doaj.art-35462e82915045fba29a8e583f015c27 |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-12-22T04:47:46Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-35462e82915045fba29a8e583f015c272022-12-21T18:38:33ZengWileyRespirology Case Reports2051-33802021-11-01911n/an/a10.1002/rcr2.867Spontaneous improvement of interstitial pneumonia with autoimmune features: A case reportHirotsugu Ohkubo0Akiko Nakano1Kohei Fujita2Yoshiyuki Ozawa3Takayuki Murase4Akio Niimi5Department of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Radiology Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Pathology and Molecular Diagnostics Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City University Graduate School of Medical Sciences Nagoya JapanAbstract Interstitial pneumonia with autoimmune features (IPAF) was proposed to describe patients with interstitial lung disease who do not meet the classification criteria for a defined connective tissue disease. Here, we report a spontaneous improvement case of IPAF. A 58‐year‐old man developed dry cough and dyspnoea. Positive result was obtained for the anti‐centromere antibody. High‐resolution computed tomography (HRCT) showed reticular abnormalities and ground‐glass opacities. Cryobiopsy specimens revealed cellular non‐specific interstitial pneumonia. The patient displayed periungual erythema and nail fold bleeding, but no sclerosis. He did not meet the criteria for systemic scleroderma, but did meet those for IPAF. Because symptoms slightly improved, the patient declined immunosuppressive treatment. After 6 months, repeated HRCT showed an apparent reduction in the area of ground‐glass opacities. The forced vital capacity improved from 2.72 to 3.47 L and serum Krebs von den Lungen (KL)‐6 decreased from 1977 to 531 U/ml, and symptoms disappeared.https://doi.org/10.1002/rcr2.867interstitial pneumonia with autoimmune featuresnon‐specific interstitial pneumoniatransbronchial cryobiopsy |
| spellingShingle | Hirotsugu Ohkubo Akiko Nakano Kohei Fujita Yoshiyuki Ozawa Takayuki Murase Akio Niimi Spontaneous improvement of interstitial pneumonia with autoimmune features: A case report Respirology Case Reports interstitial pneumonia with autoimmune features non‐specific interstitial pneumonia transbronchial cryobiopsy |
| title | Spontaneous improvement of interstitial pneumonia with autoimmune features: A case report |
| title_full | Spontaneous improvement of interstitial pneumonia with autoimmune features: A case report |
| title_fullStr | Spontaneous improvement of interstitial pneumonia with autoimmune features: A case report |
| title_full_unstemmed | Spontaneous improvement of interstitial pneumonia with autoimmune features: A case report |
| title_short | Spontaneous improvement of interstitial pneumonia with autoimmune features: A case report |
| title_sort | spontaneous improvement of interstitial pneumonia with autoimmune features a case report |
| topic | interstitial pneumonia with autoimmune features non‐specific interstitial pneumonia transbronchial cryobiopsy |
| url | https://doi.org/10.1002/rcr2.867 |
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