Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial Tumor
Autoimmune gastritis (AIG), a chronic inflammatory disease occurs as a result of a complex interaction between host-related and environmental factors. AIG may progress to severe atrophic gastritis secondary autoimmune-mediated parietal cell destruction in the stomach. AIG can be diagnosed based on a...
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| Format: | Article |
| Language: | English |
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Yong Chan Lee
2023-06-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2023-0021.pdf |
| _version_ | 1797804046884536320 |
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| author | Yong Hwan Ahn Kyo Bum Hwang Geom Seog Seo |
| author_facet | Yong Hwan Ahn Kyo Bum Hwang Geom Seog Seo |
| author_sort | Yong Hwan Ahn |
| collection | DOAJ |
| description | Autoimmune gastritis (AIG), a chronic inflammatory disease occurs as a result of a complex interaction between host-related and environmental factors. AIG may progress to severe atrophic gastritis secondary autoimmune-mediated parietal cell destruction in the stomach. AIG can be diagnosed based on anti-parietal cell antibody tests and endoscopy, which reveals widespread gastric corpus atrophy in patients with low serum pepsinogen I levels, a low pepsinogen I/II ratio, and elevated serum gastrin levels on serological testing. Tissue biopsy findings, which include mucosal atrophy and lymphocytic infiltration of the lamina propria may be useful for diagnostic confirmation. Decreased gastric acid secretion causes hypergastrinemia and enterochromaffin-like (ECL) cell proliferation, which can lead to neuroendocrine tumor development. Additionally, an autoimmune response results in parietal and chief cell injury, and proliferating ECL cells are detected in the deep mucosal layers in patients with AIG. Therefore, this condition may easily be misdiagnosed as a subepithelial tumor, and establishing a differential diagnosis for other types of subepithelial tumor accompanied by AIG is challenging. We present the case of a 54-year-old woman who was diagnosed with AIG with a concomitant subepithelial tumor based on serologic tests and biopsy findings and underwent wedge resection, which confirmed diagnosis of a schwannoma. |
| first_indexed | 2024-03-13T05:30:16Z |
| format | Article |
| id | doaj.art-35468611238e4d079f3ee1c1edf6116b |
| institution | Directory Open Access Journal |
| issn | 1738-3331 |
| language | English |
| last_indexed | 2024-03-13T05:30:16Z |
| publishDate | 2023-06-01 |
| publisher | Yong Chan Lee |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj.art-35468611238e4d079f3ee1c1edf6116b2023-06-15T04:27:21ZengYong Chan LeeThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312023-06-0123213714210.7704/kjhugr.2023.0021781Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial TumorYong Hwan Ahn0Kyo Bum Hwang1Geom Seog Seo2 Department of Internal Medicine, Plus I-miko Hospital, Suncheon, Korea Department of Internal Medicine, Plus I-miko Hospital, Suncheon, Korea Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, KoreaAutoimmune gastritis (AIG), a chronic inflammatory disease occurs as a result of a complex interaction between host-related and environmental factors. AIG may progress to severe atrophic gastritis secondary autoimmune-mediated parietal cell destruction in the stomach. AIG can be diagnosed based on anti-parietal cell antibody tests and endoscopy, which reveals widespread gastric corpus atrophy in patients with low serum pepsinogen I levels, a low pepsinogen I/II ratio, and elevated serum gastrin levels on serological testing. Tissue biopsy findings, which include mucosal atrophy and lymphocytic infiltration of the lamina propria may be useful for diagnostic confirmation. Decreased gastric acid secretion causes hypergastrinemia and enterochromaffin-like (ECL) cell proliferation, which can lead to neuroendocrine tumor development. Additionally, an autoimmune response results in parietal and chief cell injury, and proliferating ECL cells are detected in the deep mucosal layers in patients with AIG. Therefore, this condition may easily be misdiagnosed as a subepithelial tumor, and establishing a differential diagnosis for other types of subepithelial tumor accompanied by AIG is challenging. We present the case of a 54-year-old woman who was diagnosed with AIG with a concomitant subepithelial tumor based on serologic tests and biopsy findings and underwent wedge resection, which confirmed diagnosis of a schwannoma.http://www.helicojournal.org/upload/pdf/kjhugr-2023-0021.pdfautoimmunitygastritissubepithelialschwannomacase study |
| spellingShingle | Yong Hwan Ahn Kyo Bum Hwang Geom Seog Seo Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial Tumor The Korean Journal of Helicobacter and Upper Gastrointestinal Research autoimmunity gastritis subepithelial schwannoma case study |
| title | Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial Tumor |
| title_full | Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial Tumor |
| title_fullStr | Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial Tumor |
| title_full_unstemmed | Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial Tumor |
| title_short | Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial Tumor |
| title_sort | autoimmune gastritis accompanied by a schwannoma presenting as a subepithelial tumor |
| topic | autoimmunity gastritis subepithelial schwannoma case study |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2023-0021.pdf |
| work_keys_str_mv | AT yonghwanahn autoimmunegastritisaccompaniedbyaschwannomapresentingasasubepithelialtumor AT kyobumhwang autoimmunegastritisaccompaniedbyaschwannomapresentingasasubepithelialtumor AT geomseogseo autoimmunegastritisaccompaniedbyaschwannomapresentingasasubepithelialtumor |