Association between the / Ratio and Altered Body Mass Index after Bariatric Surgery
Background Current evidence support that the gut microbiota plays a potential role in obesity. Bariatric surgery can reduce excess weight and decrease the risk of life-threatening weight-related health problems and may also influence gut microbiota. In this study, we aimed to investigate the changes...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Endocrine Society
2022-06-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2022-1481.pdf |
| _version_ | 1817979341135413248 |
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| author | Yoonhong Kim Dooheon Son Bu Kyung Kim Ki Hyun Kim Kyung Won Seo Kyoungwon Jung Seun Ja Park Sanghyun Lim Jae Hyun Kim |
| author_facet | Yoonhong Kim Dooheon Son Bu Kyung Kim Ki Hyun Kim Kyung Won Seo Kyoungwon Jung Seun Ja Park Sanghyun Lim Jae Hyun Kim |
| author_sort | Yoonhong Kim |
| collection | DOAJ |
| description | Background Current evidence support that the gut microbiota plays a potential role in obesity. Bariatric surgery can reduce excess weight and decrease the risk of life-threatening weight-related health problems and may also influence gut microbiota. In this study, we aimed to investigate the changes in gut microbiota before and after bariatric surgery and evaluate the association of the gut microbial shift and altered body mass index (BMI) after bariatric surgery. Methods Between January 2019 and July 2020, stools from 58 patients scheduled for bariatric surgery were collected. Six months after bariatric surgery, stools from 22 of these patients were re-collected, and the changes in gut microbiota before and after bariatric surgery were evaluated. In addition, the differences in gut microbiota between patients with severe obesity (BMI >35 kg/m2, n=42) and healthy volunteers with normal BMI (18.8 to 22.8 kg/m2, n=41) were investigated. Results The gut microbiota of patients who underwent bariatric surgery showed increased α-diversity and differed β-diversity compared with those before surgery. Interestingly, Blautia was decreased and Bacteriodes was increased at the genus level after bariatric surgery. Further, the Blautia/Bacteroides ratio showed a positive correlation with BMI. To validate these results, we compared the gut microbiota from severely obese patients with high BMI with those from healthy volunteers and demonstrated that the Blautia/Bacteroides ratio correlated positively with BMI. Conclusion In the gut microbial analysis of patients who underwent bariatric surgery, we presented that the Blautia/Bacteroides ratio had changed after bariatric surgery and showed a positive correlation with BMI. |
| first_indexed | 2024-04-13T22:41:41Z |
| format | Article |
| id | doaj.art-3548dc11780c414d83434aa2486b8efb |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-04-13T22:41:41Z |
| publishDate | 2022-06-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-3548dc11780c414d83434aa2486b8efb2022-12-22T02:26:35ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782022-06-0137347548610.3803/EnM.2022.14812311Association between the / Ratio and Altered Body Mass Index after Bariatric SurgeryYoonhong Kim0Dooheon Son1Bu Kyung Kim2Ki Hyun Kim3Kyung Won Seo4Kyoungwon Jung5Seun Ja Park6Sanghyun Lim7Jae Hyun Kim8 Department of Surgery, Kosin University College of Medicine, Busan, Korea Cell Biotech Co. Ltd., Gimpo, Korea Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea Department of Surgery, Kosin University College of Medicine, Busan, Korea Department of Surgery, Kosin University College of Medicine, Busan, Korea Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea Cell Biotech Co. Ltd., Gimpo, Korea Department of Internal Medicine, Kosin University College of Medicine, Busan, KoreaBackground Current evidence support that the gut microbiota plays a potential role in obesity. Bariatric surgery can reduce excess weight and decrease the risk of life-threatening weight-related health problems and may also influence gut microbiota. In this study, we aimed to investigate the changes in gut microbiota before and after bariatric surgery and evaluate the association of the gut microbial shift and altered body mass index (BMI) after bariatric surgery. Methods Between January 2019 and July 2020, stools from 58 patients scheduled for bariatric surgery were collected. Six months after bariatric surgery, stools from 22 of these patients were re-collected, and the changes in gut microbiota before and after bariatric surgery were evaluated. In addition, the differences in gut microbiota between patients with severe obesity (BMI >35 kg/m2, n=42) and healthy volunteers with normal BMI (18.8 to 22.8 kg/m2, n=41) were investigated. Results The gut microbiota of patients who underwent bariatric surgery showed increased α-diversity and differed β-diversity compared with those before surgery. Interestingly, Blautia was decreased and Bacteriodes was increased at the genus level after bariatric surgery. Further, the Blautia/Bacteroides ratio showed a positive correlation with BMI. To validate these results, we compared the gut microbiota from severely obese patients with high BMI with those from healthy volunteers and demonstrated that the Blautia/Bacteroides ratio correlated positively with BMI. Conclusion In the gut microbial analysis of patients who underwent bariatric surgery, we presented that the Blautia/Bacteroides ratio had changed after bariatric surgery and showed a positive correlation with BMI.http://www.e-enm.org/upload/pdf/enm-2022-1481.pdfobesitybariatric surgerygastrointestinal microbiome |
| spellingShingle | Yoonhong Kim Dooheon Son Bu Kyung Kim Ki Hyun Kim Kyung Won Seo Kyoungwon Jung Seun Ja Park Sanghyun Lim Jae Hyun Kim Association between the / Ratio and Altered Body Mass Index after Bariatric Surgery Endocrinology and Metabolism obesity bariatric surgery gastrointestinal microbiome |
| title | Association between the / Ratio and Altered Body Mass Index after Bariatric Surgery |
| title_full | Association between the / Ratio and Altered Body Mass Index after Bariatric Surgery |
| title_fullStr | Association between the / Ratio and Altered Body Mass Index after Bariatric Surgery |
| title_full_unstemmed | Association between the / Ratio and Altered Body Mass Index after Bariatric Surgery |
| title_short | Association between the / Ratio and Altered Body Mass Index after Bariatric Surgery |
| title_sort | association between the ratio and altered body mass index after bariatric surgery |
| topic | obesity bariatric surgery gastrointestinal microbiome |
| url | http://www.e-enm.org/upload/pdf/enm-2022-1481.pdf |
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