Gender- and age-based differences in outcomes of mechanically ventilated ICU patients: a Chinese multicentre retrospective study
Abstract Background Previous studies have suggested that the gender and/or age of a patient may influence the clinical outcomes of critically ill patients. Our aim was to determine whether there are gender- and age-based differences in clinical outcomes for mechanically ventilated patients in intens...
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-021-01555-8 |
| _version_ | 1798026152338522112 |
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| author | Jia-Gui Ma Bo Zhu Li Jiang Qi Jiang Xiu-Ming Xi |
| author_facet | Jia-Gui Ma Bo Zhu Li Jiang Qi Jiang Xiu-Ming Xi |
| author_sort | Jia-Gui Ma |
| collection | DOAJ |
| description | Abstract Background Previous studies have suggested that the gender and/or age of a patient may influence the clinical outcomes of critically ill patients. Our aim was to determine whether there are gender- and age-based differences in clinical outcomes for mechanically ventilated patients in intensive care units (ICUs). Methods We performed a multicentre retrospective study involving adult patients who were admitted to the ICU and received at least 24 h of mechanical ventilation (MV). The patients were divided into two groups based on gender and, subsequently, further grouped based on gender and age < or ≥ 65 years. The primary outcome measure was hospital mortality. Results A total of 853 mechanically ventilated patients were evaluated. Of these patients, 63.2% were men and 61.5% were ≥ 65 years of age. The hospital mortality rate for men was significantly higher than that for women in the overall study population (P = 0.042), and this difference was most pronounced among elderly patients (age ≥ 65 years; P = 0.006). The durations of MV, ICU lengths of stay (LOS), and hospital LOS were significantly longer for men than for women among younger patients (P ≤ 0.013) but not among elderly patients. Multivariate logistic regression analysis revealed that male gender was independently associated with hospital mortality among elderly patients but not among younger patients. Conclusions There were important gender- and age-based differences in the outcomes among mechanically ventilated ICU patients. The combination of male gender and advanced age is strongly associated with hospital mortality. |
| first_indexed | 2024-04-11T18:31:45Z |
| format | Article |
| id | doaj.art-35490ffdcde340baafdb7b756d5f1f7c |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-04-11T18:31:45Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-35490ffdcde340baafdb7b756d5f1f7c2022-12-22T04:09:26ZengBMCBMC Anesthesiology1471-22532022-01-0122111010.1186/s12871-021-01555-8Gender- and age-based differences in outcomes of mechanically ventilated ICU patients: a Chinese multicentre retrospective studyJia-Gui Ma0Bo Zhu1Li Jiang2Qi Jiang3Xiu-Ming Xi4Department of Critical Care Medicine, Beijing Rehabilitation Hospital, Capital Medical UniversityDepartment of Critical Care Medicine, Fu Xing Hospital, Capital Medical UniversityDepartment of Critical Care Medicine, Fu Xing Hospital, Capital Medical UniversityDepartment of Critical Care Medicine, Fu Xing Hospital, Capital Medical UniversityDepartment of Critical Care Medicine, Fu Xing Hospital, Capital Medical UniversityAbstract Background Previous studies have suggested that the gender and/or age of a patient may influence the clinical outcomes of critically ill patients. Our aim was to determine whether there are gender- and age-based differences in clinical outcomes for mechanically ventilated patients in intensive care units (ICUs). Methods We performed a multicentre retrospective study involving adult patients who were admitted to the ICU and received at least 24 h of mechanical ventilation (MV). The patients were divided into two groups based on gender and, subsequently, further grouped based on gender and age < or ≥ 65 years. The primary outcome measure was hospital mortality. Results A total of 853 mechanically ventilated patients were evaluated. Of these patients, 63.2% were men and 61.5% were ≥ 65 years of age. The hospital mortality rate for men was significantly higher than that for women in the overall study population (P = 0.042), and this difference was most pronounced among elderly patients (age ≥ 65 years; P = 0.006). The durations of MV, ICU lengths of stay (LOS), and hospital LOS were significantly longer for men than for women among younger patients (P ≤ 0.013) but not among elderly patients. Multivariate logistic regression analysis revealed that male gender was independently associated with hospital mortality among elderly patients but not among younger patients. Conclusions There were important gender- and age-based differences in the outcomes among mechanically ventilated ICU patients. The combination of male gender and advanced age is strongly associated with hospital mortality.https://doi.org/10.1186/s12871-021-01555-8GenderAgeMechanical ventilationIntensive care unitOutcomeMortality |
| spellingShingle | Jia-Gui Ma Bo Zhu Li Jiang Qi Jiang Xiu-Ming Xi Gender- and age-based differences in outcomes of mechanically ventilated ICU patients: a Chinese multicentre retrospective study BMC Anesthesiology Gender Age Mechanical ventilation Intensive care unit Outcome Mortality |
| title | Gender- and age-based differences in outcomes of mechanically ventilated ICU patients: a Chinese multicentre retrospective study |
| title_full | Gender- and age-based differences in outcomes of mechanically ventilated ICU patients: a Chinese multicentre retrospective study |
| title_fullStr | Gender- and age-based differences in outcomes of mechanically ventilated ICU patients: a Chinese multicentre retrospective study |
| title_full_unstemmed | Gender- and age-based differences in outcomes of mechanically ventilated ICU patients: a Chinese multicentre retrospective study |
| title_short | Gender- and age-based differences in outcomes of mechanically ventilated ICU patients: a Chinese multicentre retrospective study |
| title_sort | gender and age based differences in outcomes of mechanically ventilated icu patients a chinese multicentre retrospective study |
| topic | Gender Age Mechanical ventilation Intensive care unit Outcome Mortality |
| url | https://doi.org/10.1186/s12871-021-01555-8 |
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