Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival
ObjectiveTo determine the relationship between survival and glioblastoma distance from the ventricular-subventricular neural stem cell niche (VSVZ).Methods502 pre-operative gadolinium-enhanced, T1-weighted MRIs with glioblastoma retrieved from an institutional dataset (n = 252) and The Cancer Imagin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.564889/full |
| _version_ | 1818927574989930496 |
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| author | Akshitkumar M. Mistry Nishit Mummareddy Sanjana Salwi Larry T. Davis Rebecca A. Ihrie Rebecca A. Ihrie |
| author_facet | Akshitkumar M. Mistry Nishit Mummareddy Sanjana Salwi Larry T. Davis Rebecca A. Ihrie Rebecca A. Ihrie |
| author_sort | Akshitkumar M. Mistry |
| collection | DOAJ |
| description | ObjectiveTo determine the relationship between survival and glioblastoma distance from the ventricular-subventricular neural stem cell niche (VSVZ).Methods502 pre-operative gadolinium-enhanced, T1-weighted MRIs with glioblastoma retrieved from an institutional dataset (n = 252) and The Cancer Imaging Atlas (n=250) were independently reviewed. The shortest distance from the tumor contrast enhancement to the nearest lateral ventricular wall, the location of the VSVZ, was measured (GBM-VSVZDist). The relationship of GBM-VSVZDist with the proportion of glioblastomas at each distance point and overall survival was explored with a Pearson’s correlation and Cox regression model, respectively, adjusting for the well-established glioblastoma prognosticators.Results244/502 glioblastomas had VSVZ contact. The proportion of non-VSVZ-contacting glioblastomas correlated inversely with GBM-VSVZDist (partial Pearson’s correlation adjusted for tumor volume R=-0.79, p=7.11x10-7). A fit of the Cox regression model adjusted for age at diagnosis, Karnofsky performance status score, post-operative treatment with temozolomide and/or radiotherapy, IDH1/2 mutation status, MGMT promoter methylation status, tumor volume, and extent of resection demonstrated a significantly decreased overall survival only when glioblastoma contacted the VSVZ. Overall survival did not correlate with GBM-VSVZDist.ConclusionsIn the two independent cohorts analyzed, glioblastomas at diagnosis were found in close proximity or in contact with the VSVZ with a proportion that decreased linearly with GBM-VSVZDist. Patient survival was only influenced by the presence or absence of a gadolinium-enhanced glioblastoma contact with the VSVZ. These results may guide analyses to test differential effectiveness of VSVZ radiation in VSVZ-contacting and non-contacting glioblastomas and/or inform patient selection criteria in clinical trials of glioblastoma radiation. |
| first_indexed | 2024-12-20T03:15:11Z |
| format | Article |
| id | doaj.art-354932d88fd94326a2d6e702f1743c47 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T03:15:11Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-354932d88fd94326a2d6e702f1743c472022-12-21T19:55:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.564889564889Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With SurvivalAkshitkumar M. Mistry0Nishit Mummareddy1Sanjana Salwi2Larry T. Davis3Rebecca A. Ihrie4Rebecca A. Ihrie5Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United StatesSchool of Medicine, Vanderbilt University, Nashville, TN, United StatesDepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, United StatesObjectiveTo determine the relationship between survival and glioblastoma distance from the ventricular-subventricular neural stem cell niche (VSVZ).Methods502 pre-operative gadolinium-enhanced, T1-weighted MRIs with glioblastoma retrieved from an institutional dataset (n = 252) and The Cancer Imaging Atlas (n=250) were independently reviewed. The shortest distance from the tumor contrast enhancement to the nearest lateral ventricular wall, the location of the VSVZ, was measured (GBM-VSVZDist). The relationship of GBM-VSVZDist with the proportion of glioblastomas at each distance point and overall survival was explored with a Pearson’s correlation and Cox regression model, respectively, adjusting for the well-established glioblastoma prognosticators.Results244/502 glioblastomas had VSVZ contact. The proportion of non-VSVZ-contacting glioblastomas correlated inversely with GBM-VSVZDist (partial Pearson’s correlation adjusted for tumor volume R=-0.79, p=7.11x10-7). A fit of the Cox regression model adjusted for age at diagnosis, Karnofsky performance status score, post-operative treatment with temozolomide and/or radiotherapy, IDH1/2 mutation status, MGMT promoter methylation status, tumor volume, and extent of resection demonstrated a significantly decreased overall survival only when glioblastoma contacted the VSVZ. Overall survival did not correlate with GBM-VSVZDist.ConclusionsIn the two independent cohorts analyzed, glioblastomas at diagnosis were found in close proximity or in contact with the VSVZ with a proportion that decreased linearly with GBM-VSVZDist. Patient survival was only influenced by the presence or absence of a gadolinium-enhanced glioblastoma contact with the VSVZ. These results may guide analyses to test differential effectiveness of VSVZ radiation in VSVZ-contacting and non-contacting glioblastomas and/or inform patient selection criteria in clinical trials of glioblastoma radiation.https://www.frontiersin.org/articles/10.3389/fonc.2020.564889/fullglioblastomasubventricular zonesurvivalstem cellglioma |
| spellingShingle | Akshitkumar M. Mistry Nishit Mummareddy Sanjana Salwi Larry T. Davis Rebecca A. Ihrie Rebecca A. Ihrie Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival Frontiers in Oncology glioblastoma subventricular zone survival stem cell glioma |
| title | Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival |
| title_full | Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival |
| title_fullStr | Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival |
| title_full_unstemmed | Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival |
| title_short | Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival |
| title_sort | glioblastoma distance from the subventricular neural stem cell niche does not correlate with survival |
| topic | glioblastoma subventricular zone survival stem cell glioma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.564889/full |
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