Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy
Aim. To estimate dynamics of secretory and motor-evacuational functions of the stomach in patients with type 1 diabetes mellitus and gastrointestinalform of diabetic neuropathy. Materials and methods. 32 patients with DM1 without gastrointestinal pathology allocated to different groups depending o...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2011-06-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5644 |
| _version_ | 1797255263418318848 |
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| author | Irina Alekseevna Kurnikova Tatiana Evgen'evna Chernyshova Irina Vladimirovna Gur'eva Guzyal' Ilgisovna Kliment'eva |
| author_facet | Irina Alekseevna Kurnikova Tatiana Evgen'evna Chernyshova Irina Vladimirovna Gur'eva Guzyal' Ilgisovna Kliment'eva |
| author_sort | Irina Alekseevna Kurnikova |
| collection | DOAJ |
| description | Aim. To estimate dynamics of secretory and motor-evacuational functions of the stomach in patients with type 1 diabetes mellitus and gastrointestinalform of diabetic neuropathy. Materials and methods. 32 patients with DM1 without gastrointestinal pathology allocated to different groups depending on DM duration (gr. 1 lessthan 10 yr, gr. 2 over 10 yr). Vegetative equilibrium was estimated from the Kerdo index, rehabilitative potential from its basic constituent (morphophysiologicalindex). The motor-evacuational function of the stomach was studied with the use of a scintillation gamma-chamber, the gastric secretoryfunction by pH measurements. Results. Half of the patients in gr 2 presented with hypersympathicotony. The frequency of hypertonic form of gastric tone increased with durationof DM while the acid-producing and evacuational functions of the stomach decreased (as estimated by pH-measurement and gastroscintiographyrespectively). The propulsive function most significantly decreased in the pyloric part. The efficacy of rehabilitation of diabetic patients with gastrointestinalform of diabetic neuropathy was much lower than in those with preserved vegetative function of the stomach. Conclusion. Impairment of evacuational function of the stomach and duodenum with DM1 duration may be a cause of unstable blood glucose level.Hypomotor dyskinesia of the upper gastrointestinal tract due to DM1 and deficit of parasympathetic innervation occurs more frequently in patientswith low rehabilitative potential. Functional changes in the gastrointestinal tract of DM1 patients do not depend on the quality of compensation ofmetabolic disorders but correlate (r=-0.39) with DM duration. It is concluded that the gastrointestinal form of diabetic neuropathy impairs rehabilitativepotential of fhe patients. |
| first_indexed | 2024-03-08T15:22:08Z |
| format | Article |
| id | doaj.art-354a37c45697473b9d8a6e000afed53c |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:03:04Z |
| publishDate | 2011-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-354a37c45697473b9d8a6e000afed53c2024-03-20T11:47:56ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782011-06-01142949710.14341/2072-0351-56445602Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathyIrina Alekseevna Kurnikova0Tatiana Evgen'evna Chernyshova1Irina Vladimirovna Gur'eva2Guzyal' Ilgisovna Kliment'eva3Izhevsk State Medical Academy, IzhevskIzhevsk State Medical Academy, IzhevskRussian Medical Academy of Post-graduate Education, MoscowIzhevsk State Medical Academy, IzhevskAim. To estimate dynamics of secretory and motor-evacuational functions of the stomach in patients with type 1 diabetes mellitus and gastrointestinalform of diabetic neuropathy. Materials and methods. 32 patients with DM1 without gastrointestinal pathology allocated to different groups depending on DM duration (gr. 1 lessthan 10 yr, gr. 2 over 10 yr). Vegetative equilibrium was estimated from the Kerdo index, rehabilitative potential from its basic constituent (morphophysiologicalindex). The motor-evacuational function of the stomach was studied with the use of a scintillation gamma-chamber, the gastric secretoryfunction by pH measurements. Results. Half of the patients in gr 2 presented with hypersympathicotony. The frequency of hypertonic form of gastric tone increased with durationof DM while the acid-producing and evacuational functions of the stomach decreased (as estimated by pH-measurement and gastroscintiographyrespectively). The propulsive function most significantly decreased in the pyloric part. The efficacy of rehabilitation of diabetic patients with gastrointestinalform of diabetic neuropathy was much lower than in those with preserved vegetative function of the stomach. Conclusion. Impairment of evacuational function of the stomach and duodenum with DM1 duration may be a cause of unstable blood glucose level.Hypomotor dyskinesia of the upper gastrointestinal tract due to DM1 and deficit of parasympathetic innervation occurs more frequently in patientswith low rehabilitative potential. Functional changes in the gastrointestinal tract of DM1 patients do not depend on the quality of compensation ofmetabolic disorders but correlate (r=-0.39) with DM duration. It is concluded that the gastrointestinal form of diabetic neuropathy impairs rehabilitativepotential of fhe patients.https://www.dia-endojournals.ru/jour/article/view/5644diabetes mellitusdiabetic vegetative neuropathyclinico-expert diagnosticsgastroscintiography |
| spellingShingle | Irina Alekseevna Kurnikova Tatiana Evgen'evna Chernyshova Irina Vladimirovna Gur'eva Guzyal' Ilgisovna Kliment'eva Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy Сахарный диабет diabetes mellitus diabetic vegetative neuropathy clinico-expert diagnostics gastroscintiography |
| title | Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy |
| title_full | Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy |
| title_fullStr | Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy |
| title_full_unstemmed | Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy |
| title_short | Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy |
| title_sort | clinico expert diagnostics of gastrointestinal form of diabetic neuropathy |
| topic | diabetes mellitus diabetic vegetative neuropathy clinico-expert diagnostics gastroscintiography |
| url | https://www.dia-endojournals.ru/jour/article/view/5644 |
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