Prevalence of chronic kidney disease in the Netherlands and its cardiovascular and renal complications
Abstract Background Knowledge on prevalence, comorbidities and consequences of chronic kidney disease (CKD) is mandatory to estimate the potential of cardiovascular risk management on a population level. We studied the prevalence of CKD with or without type 2 diabetes mellitus (T2D) and/or heart fai...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-023-03384-y |
| _version_ | 1797577498371817472 |
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| author | Marc G. Vervloet Hilda JI de Jong Jan Pander Jetty A. Overbeek |
| author_facet | Marc G. Vervloet Hilda JI de Jong Jan Pander Jetty A. Overbeek |
| author_sort | Marc G. Vervloet |
| collection | DOAJ |
| description | Abstract Background Knowledge on prevalence, comorbidities and consequences of chronic kidney disease (CKD) is mandatory to estimate the potential of cardiovascular risk management on a population level. We studied the prevalence of CKD with or without type 2 diabetes mellitus (T2D) and/or heart failure and its cardiorenal complications in The Netherlands. Methods A descriptive cross-sectional and longitudinal cohort study was performed, using data from the Dutch PHARMO Data Network. Prevalence of CKD at a single time point was determined by a recorded diagnosis or by ≥ 2 estimated glomerular filtration rate (eGFR) measurements and urine albumin/creatinine ratio (UACR) that define CKD. A representative group of adults with CKD was included in a longitudinal analysis to study cardiorenal complications. Those were followed until first complication, end of study or death, whichever occurred first. Results The prevalence of CKD was 8.9% in a representative population of 2,187,962 adult Dutch individuals. The average age of persons with CKD was 72 years, 57% were female, 19.9% had T2D, 7.7% heart failure, and 3.0% both T2D and heart failure. In the longitudinal analysis, cerebrovascular events (11/1,000 person-years), hospitalizations for heart failure (10/1,000 person-years), myocardial infarction (5.5/1,000 person-years), and hospitalization for CKD (6.2/1,000 person-years) were the most common first cardiorenal complications. People with CKD with T2D and/or heart failure generally had higher rates of cardiovascular or renal complications or mortality than people with CKD without these comorbidities. Conclusion The prevalence of CKD in The Netherlands is 8.9%. People with T2D or heart failure, or both, in addition to CKD, had numerically higher mortality and cardiorenal complication rates than people without these comorbidities. Optimizing up-to-date cardiovascular risk management in these high-risk individuals may provide health benefits. |
| first_indexed | 2024-03-10T22:09:10Z |
| format | Article |
| id | doaj.art-354c001683574e74ae88cb50acf3e259 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-03-10T22:09:10Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-354c001683574e74ae88cb50acf3e2592023-11-19T12:39:30ZengBMCBMC Nephrology1471-23692023-11-012411810.1186/s12882-023-03384-yPrevalence of chronic kidney disease in the Netherlands and its cardiovascular and renal complicationsMarc G. Vervloet0Hilda JI de Jong1Jan Pander2Jetty A. Overbeek3Nephrology Department, Amsterdam UMCPHARMO Institute for Drug Outcomes ResearchEvidence Generation Lead, AstraZeneca BVPHARMO Institute for Drug Outcomes ResearchAbstract Background Knowledge on prevalence, comorbidities and consequences of chronic kidney disease (CKD) is mandatory to estimate the potential of cardiovascular risk management on a population level. We studied the prevalence of CKD with or without type 2 diabetes mellitus (T2D) and/or heart failure and its cardiorenal complications in The Netherlands. Methods A descriptive cross-sectional and longitudinal cohort study was performed, using data from the Dutch PHARMO Data Network. Prevalence of CKD at a single time point was determined by a recorded diagnosis or by ≥ 2 estimated glomerular filtration rate (eGFR) measurements and urine albumin/creatinine ratio (UACR) that define CKD. A representative group of adults with CKD was included in a longitudinal analysis to study cardiorenal complications. Those were followed until first complication, end of study or death, whichever occurred first. Results The prevalence of CKD was 8.9% in a representative population of 2,187,962 adult Dutch individuals. The average age of persons with CKD was 72 years, 57% were female, 19.9% had T2D, 7.7% heart failure, and 3.0% both T2D and heart failure. In the longitudinal analysis, cerebrovascular events (11/1,000 person-years), hospitalizations for heart failure (10/1,000 person-years), myocardial infarction (5.5/1,000 person-years), and hospitalization for CKD (6.2/1,000 person-years) were the most common first cardiorenal complications. People with CKD with T2D and/or heart failure generally had higher rates of cardiovascular or renal complications or mortality than people with CKD without these comorbidities. Conclusion The prevalence of CKD in The Netherlands is 8.9%. People with T2D or heart failure, or both, in addition to CKD, had numerically higher mortality and cardiorenal complication rates than people without these comorbidities. Optimizing up-to-date cardiovascular risk management in these high-risk individuals may provide health benefits.https://doi.org/10.1186/s12882-023-03384-yCardiorenal ComplicationsChronic Kidney DiseaseDiabetes MellitusHeart FailurePrevalence |
| spellingShingle | Marc G. Vervloet Hilda JI de Jong Jan Pander Jetty A. Overbeek Prevalence of chronic kidney disease in the Netherlands and its cardiovascular and renal complications BMC Nephrology Cardiorenal Complications Chronic Kidney Disease Diabetes Mellitus Heart Failure Prevalence |
| title | Prevalence of chronic kidney disease in the Netherlands and its cardiovascular and renal complications |
| title_full | Prevalence of chronic kidney disease in the Netherlands and its cardiovascular and renal complications |
| title_fullStr | Prevalence of chronic kidney disease in the Netherlands and its cardiovascular and renal complications |
| title_full_unstemmed | Prevalence of chronic kidney disease in the Netherlands and its cardiovascular and renal complications |
| title_short | Prevalence of chronic kidney disease in the Netherlands and its cardiovascular and renal complications |
| title_sort | prevalence of chronic kidney disease in the netherlands and its cardiovascular and renal complications |
| topic | Cardiorenal Complications Chronic Kidney Disease Diabetes Mellitus Heart Failure Prevalence |
| url | https://doi.org/10.1186/s12882-023-03384-y |
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