Platelet-Derived Microparticles are an Important Biomarker in Patients with Cancer-Associated Thrombosis
Yuta Yamanaka, Yusuke Sawai, Shosaku Nomura First Department of Internal Medicine, Kansai Medical University, Hirakata, JapanCorrespondence: Shosaku NomuraFirst Department of Internal Medicine, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, JapanTel + 81 724 45 1000Fax + 81 72...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-01-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/platelet-derived-microparticles-are-an-important-biomarker-in-patients-peer-reviewed-article-IJGM |
| _version_ | 1818042692512251904 |
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| author | Yamanaka Y Sawai Y Nomura S |
| author_facet | Yamanaka Y Sawai Y Nomura S |
| author_sort | Yamanaka Y |
| collection | DOAJ |
| description | Yuta Yamanaka, Yusuke Sawai, Shosaku Nomura First Department of Internal Medicine, Kansai Medical University, Hirakata, JapanCorrespondence: Shosaku NomuraFirst Department of Internal Medicine, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, JapanTel + 81 724 45 1000Fax + 81 725 32 1113Email shosaku-n@mbp.ocn.ne.jpBackground: Platelet-derived microparticles (PDMPs) that ultimately cause vascular complications might be used as a tool to assess thrombotic areas. We identified PDMPs, high-mobility group box-1 (HMGB1) and soluble endothelial protein C receptor (sEPCR) as useful prognosis indicators for cancer-related thrombosis (CAT) to evaluate the utility of PDMPs in cancer patients.Methods: We investigated 232 cancer patients: 24 (10.3%) had thrombotic complications within 6 months after their first examination. Levels of PDMP and biomarkers were measured by enzyme-linked immunosorbent assay.Results: The levels of PDMPs, HMGB1 and sEPCR were higher in cancer patients compared with controls. In particular, these levels were significantly elevated in lung cancer patients compared with controls, and all were higher in CAT-positive patients compared with CAT-negative patients. In particular, PDMP levels in CAT-positive patients were significantly elevated compared with CAT-negative patients. PDMP levels were significantly lower in patients who lived for more than 901 days after their first examination compared with previous data. PDMP levels were positively correlated with HMGB1, and caused the dose-dependent elevation of PDMPs in vitro using platelet-rich plasma from healthy persons.Conclusion: The combined increase in PDMP and HMGB1 levels might be related to CAT in cancer patients. Therefore, coagulatory dysfunction may result from increased levels of these biomarkers and contribute to the poor prognosis of cancer patients.Keywords: PDMP, CAT, HMGB1, sEPCR, cancer patients |
| first_indexed | 2024-12-10T08:50:21Z |
| format | Article |
| id | doaj.art-354d650ff4424b2c855e0a5c2cd9914d |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-10T08:50:21Z |
| publishDate | 2020-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-354d650ff4424b2c855e0a5c2cd9914d2022-12-22T01:55:37ZengDove Medical PressInternational Journal of General Medicine1178-70742020-01-01Volume 1249149750848Platelet-Derived Microparticles are an Important Biomarker in Patients with Cancer-Associated ThrombosisYamanaka YSawai YNomura SYuta Yamanaka, Yusuke Sawai, Shosaku Nomura First Department of Internal Medicine, Kansai Medical University, Hirakata, JapanCorrespondence: Shosaku NomuraFirst Department of Internal Medicine, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, JapanTel + 81 724 45 1000Fax + 81 725 32 1113Email shosaku-n@mbp.ocn.ne.jpBackground: Platelet-derived microparticles (PDMPs) that ultimately cause vascular complications might be used as a tool to assess thrombotic areas. We identified PDMPs, high-mobility group box-1 (HMGB1) and soluble endothelial protein C receptor (sEPCR) as useful prognosis indicators for cancer-related thrombosis (CAT) to evaluate the utility of PDMPs in cancer patients.Methods: We investigated 232 cancer patients: 24 (10.3%) had thrombotic complications within 6 months after their first examination. Levels of PDMP and biomarkers were measured by enzyme-linked immunosorbent assay.Results: The levels of PDMPs, HMGB1 and sEPCR were higher in cancer patients compared with controls. In particular, these levels were significantly elevated in lung cancer patients compared with controls, and all were higher in CAT-positive patients compared with CAT-negative patients. In particular, PDMP levels in CAT-positive patients were significantly elevated compared with CAT-negative patients. PDMP levels were significantly lower in patients who lived for more than 901 days after their first examination compared with previous data. PDMP levels were positively correlated with HMGB1, and caused the dose-dependent elevation of PDMPs in vitro using platelet-rich plasma from healthy persons.Conclusion: The combined increase in PDMP and HMGB1 levels might be related to CAT in cancer patients. Therefore, coagulatory dysfunction may result from increased levels of these biomarkers and contribute to the poor prognosis of cancer patients.Keywords: PDMP, CAT, HMGB1, sEPCR, cancer patientshttps://www.dovepress.com/platelet-derived-microparticles-are-an-important-biomarker-in-patients-peer-reviewed-article-IJGMpdmpcathmgb1sepcrcancer patients |
| spellingShingle | Yamanaka Y Sawai Y Nomura S Platelet-Derived Microparticles are an Important Biomarker in Patients with Cancer-Associated Thrombosis International Journal of General Medicine pdmp cat hmgb1 sepcr cancer patients |
| title | Platelet-Derived Microparticles are an Important Biomarker in Patients with Cancer-Associated Thrombosis |
| title_full | Platelet-Derived Microparticles are an Important Biomarker in Patients with Cancer-Associated Thrombosis |
| title_fullStr | Platelet-Derived Microparticles are an Important Biomarker in Patients with Cancer-Associated Thrombosis |
| title_full_unstemmed | Platelet-Derived Microparticles are an Important Biomarker in Patients with Cancer-Associated Thrombosis |
| title_short | Platelet-Derived Microparticles are an Important Biomarker in Patients with Cancer-Associated Thrombosis |
| title_sort | platelet derived microparticles are an important biomarker in patients with cancer associated thrombosis |
| topic | pdmp cat hmgb1 sepcr cancer patients |
| url | https://www.dovepress.com/platelet-derived-microparticles-are-an-important-biomarker-in-patients-peer-reviewed-article-IJGM |
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