Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. Dratman
A comprehensive review was conducted to compile the contributions of Mary B. Dratman and studies by other researchers in the field of nongenomic actions of thyroid hormones in adult mammalian brain. Dratman and her collaborators authored roughly half of the papers in this area. It has been almost fi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1240265/full |
| _version_ | 1797670020202889216 |
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| author | Nilkanta Chakrabarti Nilkanta Chakrabarti Pradip K. Sarkar Arun K. Ray Joseph V. Martin |
| author_facet | Nilkanta Chakrabarti Nilkanta Chakrabarti Pradip K. Sarkar Arun K. Ray Joseph V. Martin |
| author_sort | Nilkanta Chakrabarti |
| collection | DOAJ |
| description | A comprehensive review was conducted to compile the contributions of Mary B. Dratman and studies by other researchers in the field of nongenomic actions of thyroid hormones in adult mammalian brain. Dratman and her collaborators authored roughly half of the papers in this area. It has been almost fifty years since Dratman introduced the novel concept of thyroid hormones as neurotransmitters for the first time. The characterization of unique brain-region specific accumulation of thyroid hormones within the nerve terminals in adult mammals was a remarkable contribution by Dratman. It suggested a neurotransmitter- or neuromodulator-like role of thyroid hormone and/or its derivative, 3-iodothyronamine within adrenergic systems in adult mammalian brain. Several studies by other researchers using synaptosomes as a model system, have contributed to the concept of direct nongenomic actions of thyroid hormones at synaptic regions by establishing that thyroid hormones or their derivatives can bind to synaptosomal membranes, alter membrane functions including enzymatic activities and ion transport, elicit Ca2+/NO-dependent signaling pathways and induce substrate-protein phosphorylation. Such findings can help to explain the physiological and pathophysiological roles of thyroid hormone in psychobehavioral control in adult mammalian brain. However, the exact mode of nongenomic actions of thyroid hormones at nerve terminals in adult mammalian brain awaits further study. |
| first_indexed | 2024-03-11T20:53:27Z |
| format | Article |
| id | doaj.art-354f1ce6747a448ebaa4f8e873ce6c7f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T20:53:27Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-354f1ce6747a448ebaa4f8e873ce6c7f2023-09-30T22:05:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-09-011410.3389/fendo.2023.12402651240265Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. DratmanNilkanta Chakrabarti0Nilkanta Chakrabarti1Pradip K. Sarkar2Arun K. Ray3Joseph V. Martin4Department of Physiology, University of Calcutta, Kolkata, West Bengal, India(CPEPA-UGC) Centre for Electro-Physiological and Neuroimaging studies including Mathematical Modelling, University of Calcutta, Kolkata, West Bengal, IndiaDepartment of Basic Sciences, Parker University, Dallas, TX, United StatesDepartment of Molecular Medicine, Bose Institute, P-1/12 CIT Scheme VII-M, Kolkata, IndiaBiology Department, Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, United StatesA comprehensive review was conducted to compile the contributions of Mary B. Dratman and studies by other researchers in the field of nongenomic actions of thyroid hormones in adult mammalian brain. Dratman and her collaborators authored roughly half of the papers in this area. It has been almost fifty years since Dratman introduced the novel concept of thyroid hormones as neurotransmitters for the first time. The characterization of unique brain-region specific accumulation of thyroid hormones within the nerve terminals in adult mammals was a remarkable contribution by Dratman. It suggested a neurotransmitter- or neuromodulator-like role of thyroid hormone and/or its derivative, 3-iodothyronamine within adrenergic systems in adult mammalian brain. Several studies by other researchers using synaptosomes as a model system, have contributed to the concept of direct nongenomic actions of thyroid hormones at synaptic regions by establishing that thyroid hormones or their derivatives can bind to synaptosomal membranes, alter membrane functions including enzymatic activities and ion transport, elicit Ca2+/NO-dependent signaling pathways and induce substrate-protein phosphorylation. Such findings can help to explain the physiological and pathophysiological roles of thyroid hormone in psychobehavioral control in adult mammalian brain. However, the exact mode of nongenomic actions of thyroid hormones at nerve terminals in adult mammalian brain awaits further study.https://www.frontiersin.org/articles/10.3389/fendo.2023.1240265/fulltriiodothyroninethyroxinethyroninethyronaminesynaptosomes |
| spellingShingle | Nilkanta Chakrabarti Nilkanta Chakrabarti Pradip K. Sarkar Arun K. Ray Joseph V. Martin Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. Dratman Frontiers in Endocrinology triiodothyronine thyroxine thyronine thyronamine synaptosomes |
| title | Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. Dratman |
| title_full | Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. Dratman |
| title_fullStr | Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. Dratman |
| title_full_unstemmed | Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. Dratman |
| title_short | Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. Dratman |
| title_sort | unveiling the nongenomic actions of thyroid hormones in adult mammalian brain the legacy of mary b dratman |
| topic | triiodothyronine thyroxine thyronine thyronamine synaptosomes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1240265/full |
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