Urban, traffic- related particles and lung tumors in urethane treated mice
OBJECTIVE: The present study was designed to evaluate the effects of urban, traffic-related, fine particulate matter (PM2.5) on mice lung tumorigenesis under controlled exposure conditions. METHODS: Four groups of female Swiss mice were treated with intraperitonial injections of urethane and saline...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2011-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000600022 |
| _version_ | 1811229691966652416 |
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| author | Fernanda Alves Cangerana Pereira Miriam Lemos Thais Mauad João Vicente de Assunção Paulo Hilário Nascimento Saldiva |
| author_facet | Fernanda Alves Cangerana Pereira Miriam Lemos Thais Mauad João Vicente de Assunção Paulo Hilário Nascimento Saldiva |
| author_sort | Fernanda Alves Cangerana Pereira |
| collection | DOAJ |
| description | OBJECTIVE: The present study was designed to evaluate the effects of urban, traffic-related, fine particulate matter (PM2.5) on mice lung tumorigenesis under controlled exposure conditions. METHODS: Four groups of female Swiss mice were treated with intraperitonial injections of urethane and saline solution. Urethane was used to start the carcinogenesis process. The animals were housed in two chambers receiving filtered and polluted air. In the polluted air chamber, pollutant levels were low. After two months of exposure, the animals were euthanized and lung tumoral nodules were counted. RESULTS: Saline-treated animals showed no nodules. Urethane-treated animals showed 2.0+2.0 and 4.0+3.0 nodules respectively, in the filtered and non-filtered chambers (p = 0.02), thus showing experimental evidence of increased carcinogenic-induced lung cancer with increasing PM2.5 exposure. CONCLUSION: Our data support the concept that low levels of PM2.5 may increase the risk of developing lung tumors. |
| first_indexed | 2024-04-12T10:17:46Z |
| format | Article |
| id | doaj.art-35511e15e7434cf3ab6e42e45dc716cb |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T10:17:46Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-35511e15e7434cf3ab6e42e45dc716cb2022-12-22T03:37:09ZengElsevier EspañaClinics1807-59321980-53222011-01-016661051105410.1590/S1807-59322011000600022Urban, traffic- related particles and lung tumors in urethane treated miceFernanda Alves Cangerana PereiraMiriam LemosThais MauadJoão Vicente de AssunçãoPaulo Hilário Nascimento SaldivaOBJECTIVE: The present study was designed to evaluate the effects of urban, traffic-related, fine particulate matter (PM2.5) on mice lung tumorigenesis under controlled exposure conditions. METHODS: Four groups of female Swiss mice were treated with intraperitonial injections of urethane and saline solution. Urethane was used to start the carcinogenesis process. The animals were housed in two chambers receiving filtered and polluted air. In the polluted air chamber, pollutant levels were low. After two months of exposure, the animals were euthanized and lung tumoral nodules were counted. RESULTS: Saline-treated animals showed no nodules. Urethane-treated animals showed 2.0+2.0 and 4.0+3.0 nodules respectively, in the filtered and non-filtered chambers (p = 0.02), thus showing experimental evidence of increased carcinogenic-induced lung cancer with increasing PM2.5 exposure. CONCLUSION: Our data support the concept that low levels of PM2.5 may increase the risk of developing lung tumors.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000600022Air PollutantsParticulate MatterLung CancerLung NodulesUrethane |
| spellingShingle | Fernanda Alves Cangerana Pereira Miriam Lemos Thais Mauad João Vicente de Assunção Paulo Hilário Nascimento Saldiva Urban, traffic- related particles and lung tumors in urethane treated mice Clinics Air Pollutants Particulate Matter Lung Cancer Lung Nodules Urethane |
| title | Urban, traffic- related particles and lung tumors in urethane treated mice |
| title_full | Urban, traffic- related particles and lung tumors in urethane treated mice |
| title_fullStr | Urban, traffic- related particles and lung tumors in urethane treated mice |
| title_full_unstemmed | Urban, traffic- related particles and lung tumors in urethane treated mice |
| title_short | Urban, traffic- related particles and lung tumors in urethane treated mice |
| title_sort | urban traffic related particles and lung tumors in urethane treated mice |
| topic | Air Pollutants Particulate Matter Lung Cancer Lung Nodules Urethane |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000600022 |
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