TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma

TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma

Abstract Background Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outcomes from targeting the PI3K pathway have been underwhelming and the dev...

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Bibliographic Details
Main Authors: Kara M. Ruicci, Jalna Meens, Paul Plantinga, William Stecho, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, Joe S. Mymryk, John W. Barrett, Christopher J. Howlett, Paul C. Boutros, Laurie Ailles, Anthony C. Nichols
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Alpelisib
BYL719
PI3-kinase
PI3K
Head and neck cancer
HNSCC
Online Access:http://link.springer.com/article/10.1186/s13046-020-01713-9

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