Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies
Purpose. Statins are widely prescribed drugs for lowering cholesterol. Some studies have suggested that statins can prevent breast cancer recurrence and reduce mortality rate. However they are not conclusive. Present systematic review and meta-analysis of published cohort studies was conducted to de...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-02-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/25049 |
| _version_ | 1797728324789731328 |
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| author | Marjan Mansourian Shaghayegh Haghjooy-Javanmard Azadeh Eshraghi Golnaz Vaseghi Alireza Hayatshahi Jean Thomas |
| author_facet | Marjan Mansourian Shaghayegh Haghjooy-Javanmard Azadeh Eshraghi Golnaz Vaseghi Alireza Hayatshahi Jean Thomas |
| author_sort | Marjan Mansourian |
| collection | DOAJ |
| description | Purpose. Statins are widely prescribed drugs for lowering cholesterol. Some studies have suggested that statins can prevent breast cancer recurrence and reduce mortality rate. However they are not conclusive. Present systematic review and meta-analysis of published cohort studies was conducted to determine the effects of statins intake and risk of breast cancer recurrence and mortality rate. Methods. Online databases (PubMed, Embase, Scopus, EBSCO and Cochrane Collaboration) were searched through October 2014. Pooled relative risks and 95 % confidence intervals were calculated with random-effects. Results. A total of 8 cohort studies (4 for recurrence 2 for mortality and 2 for both) involving 124669 participants with breast cancer were eligible. Our results suggest a significant reduction in recurrence (OR= 0.79. I2= 38%) and death (OR = 0.84, I2 = 8.58 %) among statin users. Conclusion. Our meta-analysis suggests that breast cancer patients will benefit from statin intake, however from these cohorts we are unable to differentiate between various statins in terms of effectiveness and duration of use. We highly propose conducting randomized clinical trials.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page. |
| first_indexed | 2024-03-12T11:12:25Z |
| format | Article |
| id | doaj.art-355363d468f8460ca08419b674b3543a |
| institution | Directory Open Access Journal |
| issn | 1482-1826 |
| language | English |
| last_indexed | 2024-03-12T11:12:25Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmaceutical Sciences |
| spelling | doaj.art-355363d468f8460ca08419b674b3543a2023-09-02T02:37:23ZengFrontiers Media S.A.Journal of Pharmacy & Pharmaceutical Sciences1482-18262016-02-0119110.18433/J3202BStatins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational StudiesMarjan Mansourian0Shaghayegh Haghjooy-Javanmard1Azadeh Eshraghi2Golnaz Vaseghi3Alireza Hayatshahi4Jean Thomas5Applied Physiology Research Center and Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Pharmacology and Toxicology, Faculty of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran.Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Pharmacy Practice, School of Pharmacy, Loma Linda university, California, USA.Department of Pharmacy Practice, School of Pharmacy, Loma Linda university, California, USA.Purpose. Statins are widely prescribed drugs for lowering cholesterol. Some studies have suggested that statins can prevent breast cancer recurrence and reduce mortality rate. However they are not conclusive. Present systematic review and meta-analysis of published cohort studies was conducted to determine the effects of statins intake and risk of breast cancer recurrence and mortality rate. Methods. Online databases (PubMed, Embase, Scopus, EBSCO and Cochrane Collaboration) were searched through October 2014. Pooled relative risks and 95 % confidence intervals were calculated with random-effects. Results. A total of 8 cohort studies (4 for recurrence 2 for mortality and 2 for both) involving 124669 participants with breast cancer were eligible. Our results suggest a significant reduction in recurrence (OR= 0.79. I2= 38%) and death (OR = 0.84, I2 = 8.58 %) among statin users. Conclusion. Our meta-analysis suggests that breast cancer patients will benefit from statin intake, however from these cohorts we are unable to differentiate between various statins in terms of effectiveness and duration of use. We highly propose conducting randomized clinical trials. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/25049 |
| spellingShingle | Marjan Mansourian Shaghayegh Haghjooy-Javanmard Azadeh Eshraghi Golnaz Vaseghi Alireza Hayatshahi Jean Thomas Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies Journal of Pharmacy & Pharmaceutical Sciences |
| title | Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies |
| title_full | Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies |
| title_fullStr | Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies |
| title_full_unstemmed | Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies |
| title_short | Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies |
| title_sort | statins use and risk of breast cancer recurrence and death a systematic review and meta analysis of observational studies |
| url | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/25049 |
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