Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
Alzheimer’s Disease (AD) is a slowly progressing neurodegenerative disorder representing a major health concern worldwide. This disorder is characterised by progressive dementia and cognitive decline. The pathological hallmarks of AD include the presence of Aβ plaques and tau neurofibrils. Researc...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/8261/20273_CE[Ra1]_F(GH)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
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| author | Adnan Bashir Bhatti Muhammad Usman Farhan Ali Siddique Akbar Satti |
| author_facet | Adnan Bashir Bhatti Muhammad Usman Farhan Ali Siddique Akbar Satti |
| author_sort | Adnan Bashir Bhatti |
| collection | DOAJ |
| description | Alzheimer’s Disease (AD) is a slowly progressing neurodegenerative disorder representing a major health concern worldwide. This
disorder is characterised by progressive dementia and cognitive decline. The pathological hallmarks of AD include the presence of Aβ
plaques and tau neurofibrils. Research has shown that oxidative stress represents a major risk factor associated with AD pathology.
Accumulation of Aβ plaques and relative lack of antioxidant defence mechanisms, including cellular antioxidant enzymes and dietary
antioxidants like vitamins, assist in the exacerbation of oxidative stress. Reactive Oxygen Species (ROS) produced as the result of
oxidative stress, that increase structural and functional abnormalities in brain neurons, which then manifests as dementia and decline in
cognition. Data from numerous epidemiological studies suggests that nutrition is one of the most important yet modifiable risk factors for
AD. Since oxidative stress contributes a great deal in the development and progression of AD, anything that could attenuate oxidative
stress would help in decreasing the prevalence and incidence of AD. There is increasing evidence that supports the use of different
antioxidant as an adjuvant treatment for AD. Vitamins are one such antioxidant that can be used as an adjuvant in AD treatment. This
paper will focus on the evidence, based on current literature, linking the use of vitamin supplementations as an adjuvant treatment
for AD. |
| first_indexed | 2024-12-12T23:28:20Z |
| format | Article |
| id | doaj.art-35542dc38f2946159eb93d146bc8c056 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-12T23:28:20Z |
| publishDate | 2016-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-35542dc38f2946159eb93d146bc8c0562022-12-22T00:07:54ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-08-01108OE07OE1110.7860/JCDR/2016/20273.8261Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s DiseaseAdnan Bashir Bhatti0Muhammad Usman1Farhan Ali2Siddique Akbar Satti3Research Fellow, Department of Medicine, Capital Development Authority (CDA) Hospital, Islamabad, Pakistan. Research Fellow, Department of Medicine, Jinnah Hospital Lahore (JHL)/Allama Iqbal Medical College (AIMC), Lahore, Pakistan. Associate Professor, Department of Medicine, Capital Development Authority (CDA) Hospital, Islamabad, Pakistan. Professor Head, Department of Medicine, Capital Development Authority (CDA) Hospital, Islamabad, Pakistan.Alzheimer’s Disease (AD) is a slowly progressing neurodegenerative disorder representing a major health concern worldwide. This disorder is characterised by progressive dementia and cognitive decline. The pathological hallmarks of AD include the presence of Aβ plaques and tau neurofibrils. Research has shown that oxidative stress represents a major risk factor associated with AD pathology. Accumulation of Aβ plaques and relative lack of antioxidant defence mechanisms, including cellular antioxidant enzymes and dietary antioxidants like vitamins, assist in the exacerbation of oxidative stress. Reactive Oxygen Species (ROS) produced as the result of oxidative stress, that increase structural and functional abnormalities in brain neurons, which then manifests as dementia and decline in cognition. Data from numerous epidemiological studies suggests that nutrition is one of the most important yet modifiable risk factors for AD. Since oxidative stress contributes a great deal in the development and progression of AD, anything that could attenuate oxidative stress would help in decreasing the prevalence and incidence of AD. There is increasing evidence that supports the use of different antioxidant as an adjuvant treatment for AD. Vitamins are one such antioxidant that can be used as an adjuvant in AD treatment. This paper will focus on the evidence, based on current literature, linking the use of vitamin supplementations as an adjuvant treatment for AD.https://jcdr.net/articles/PDF/8261/20273_CE[Ra1]_F(GH)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdfantioxidant vitaminsoxidative stressreactive oxygen species |
| spellingShingle | Adnan Bashir Bhatti Muhammad Usman Farhan Ali Siddique Akbar Satti Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease Journal of Clinical and Diagnostic Research antioxidant vitamins oxidative stress reactive oxygen species |
| title | Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease |
| title_full | Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease |
| title_fullStr | Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease |
| title_full_unstemmed | Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease |
| title_short | Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease |
| title_sort | vitamin supplementation as an adjuvant treatment for alzheimer s disease |
| topic | antioxidant vitamins oxidative stress reactive oxygen species |
| url | https://jcdr.net/articles/PDF/8261/20273_CE[Ra1]_F(GH)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
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