The role of PET imaging in the evaluation of prognosis in patients with chronicdisorders of consciousness
<p><strong>Objective</strong> To explore the role of <sup>18</sup>F-fluoro-2-deoxy-D-glucose (<sup>18</sup>F-FDG) PET imaging for evaluation of the prognosis of patients with chronic disorders of consciousness. <strong>Methods </strong> <s...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2015-12-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/1318 |
| _version_ | 1818289932403212288 |
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| author | Jing ZHANG Zhi-yong QUAN Xiao-gang KANG Qiong GAO Wen JIANG |
| author_facet | Jing ZHANG Zhi-yong QUAN Xiao-gang KANG Qiong GAO Wen JIANG |
| author_sort | Jing ZHANG |
| collection | DOAJ |
| description | <p><strong>Objective</strong> To explore the role of <sup>18</sup>F-fluoro-2-deoxy-D-glucose (<sup>18</sup>F-FDG) PET imaging for evaluation of the prognosis of patients with chronic disorders of consciousness. <strong>Methods </strong> <sup>18</sup>F-FDG PET was performed to analyze glucose metabolism of external and internal awareness networks in 20 patients with chronic disorders of consciousness, and to calculate standardized uptake value (SUV) of each region. Compare the SUV of each region between conscious [Glasgow Outcome Scale-Extended (GOS-E) > 2] and unconscious (GOS-E ≤ 2) patients after 6 months follow-up. <strong>Results</strong> After 6 months, one case was lost, 8 cases recovered consciousness during the follow-up, 11 were unconscious (2 cases) or dead (9 cases). The age of unconscious or dead patients was significantly higher than that of conscious (<em>P</em> = 0.001), while the Coma Recovery Scale-Revised (CRS-R) score (<em>P</em> = 0.030) and the SUV of bilateral prefrontal lobes (left<em> P</em> = 0.000, right <em>P </em>= 0.002), bilateral parietal lobes (left <em>P</em> = 0.003, right <em>P</em> = 0.007), bilateral precuneus (left <em>P</em> = 0.000, right <em>P</em> = 0.003), anterior (<em>P</em> = 0.001) and posterior (<em>P</em> = 0.006) cingulate cortices of unconscious or dead patients were significantly lower than that of conscious patients.<strong> Conclusions</strong> The SUV of externaland internal awareness networks in <sup>18</sup>F-FDG PET imaging is related to the prognosis of patients with chronic disorders of consciousness. The higher the SUV is, the better prognosis will be achieved.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.12.003</p> |
| first_indexed | 2024-12-13T02:20:08Z |
| format | Article |
| id | doaj.art-3556030751404e95954585612e19ca34 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-13T02:20:08Z |
| publishDate | 2015-12-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-3556030751404e95954585612e19ca342022-12-22T00:02:47ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312015-12-0115129409431304The role of PET imaging in the evaluation of prognosis in patients with chronicdisorders of consciousnessJing ZHANG0Zhi-yong QUAN1Xiao-gang KANG2Qiong GAO3Wen JIANG4Department of Neurology, Xijing Hospital of the Fourth Military Medical University of Chinese PLA, Xi'an 710032, Shanxi, ChinaDepartment of Nuclear Medicine, Xijing Hospital of the Fourth Military Medical University of Chinese PLA, Xi'an 710032, Shanxi, ChinaDepartment of Neurology, Xijing Hospital of the Fourth Military Medical University of Chinese PLA, Xi'an 710032, Shanxi, ChinaDepartment of Neurology, Xijing Hospital of the Fourth Military Medical University of Chinese PLA, Xi'an 710032, Shanxi, ChinaDepartment of Neurology, Xijing Hospital of the Fourth Military Medical University of Chinese PLA, Xi'an 710032, Shanxi, China<p><strong>Objective</strong> To explore the role of <sup>18</sup>F-fluoro-2-deoxy-D-glucose (<sup>18</sup>F-FDG) PET imaging for evaluation of the prognosis of patients with chronic disorders of consciousness. <strong>Methods </strong> <sup>18</sup>F-FDG PET was performed to analyze glucose metabolism of external and internal awareness networks in 20 patients with chronic disorders of consciousness, and to calculate standardized uptake value (SUV) of each region. Compare the SUV of each region between conscious [Glasgow Outcome Scale-Extended (GOS-E) > 2] and unconscious (GOS-E ≤ 2) patients after 6 months follow-up. <strong>Results</strong> After 6 months, one case was lost, 8 cases recovered consciousness during the follow-up, 11 were unconscious (2 cases) or dead (9 cases). The age of unconscious or dead patients was significantly higher than that of conscious (<em>P</em> = 0.001), while the Coma Recovery Scale-Revised (CRS-R) score (<em>P</em> = 0.030) and the SUV of bilateral prefrontal lobes (left<em> P</em> = 0.000, right <em>P </em>= 0.002), bilateral parietal lobes (left <em>P</em> = 0.003, right <em>P</em> = 0.007), bilateral precuneus (left <em>P</em> = 0.000, right <em>P</em> = 0.003), anterior (<em>P</em> = 0.001) and posterior (<em>P</em> = 0.006) cingulate cortices of unconscious or dead patients were significantly lower than that of conscious patients.<strong> Conclusions</strong> The SUV of externaland internal awareness networks in <sup>18</sup>F-FDG PET imaging is related to the prognosis of patients with chronic disorders of consciousness. The higher the SUV is, the better prognosis will be achieved.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.12.003</p>http://www.cjcnn.org/index.php/cjcnn/article/view/1318Consciousness disordersPositron-emission tomographyPrognosis |
| spellingShingle | Jing ZHANG Zhi-yong QUAN Xiao-gang KANG Qiong GAO Wen JIANG The role of PET imaging in the evaluation of prognosis in patients with chronicdisorders of consciousness Chinese Journal of Contemporary Neurology and Neurosurgery Consciousness disorders Positron-emission tomography Prognosis |
| title | The role of PET imaging in the evaluation of prognosis in patients with chronicdisorders of consciousness |
| title_full | The role of PET imaging in the evaluation of prognosis in patients with chronicdisorders of consciousness |
| title_fullStr | The role of PET imaging in the evaluation of prognosis in patients with chronicdisorders of consciousness |
| title_full_unstemmed | The role of PET imaging in the evaluation of prognosis in patients with chronicdisorders of consciousness |
| title_short | The role of PET imaging in the evaluation of prognosis in patients with chronicdisorders of consciousness |
| title_sort | role of pet imaging in the evaluation of prognosis in patients with chronicdisorders of consciousness |
| topic | Consciousness disorders Positron-emission tomography Prognosis |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/1318 |
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