Replacement Therapy with the Surfactant Alveofact for Neonatal Respiratory Distress Syndrome: A Pilot Study
Objective: to evaluate the efficacy of alveofact in neonatal infants with respiratory distress syndrome (RDS). Subjects and methods. The trial enrolled 5 premature neonatal infants. Their mean gestational age was 30.2±2.3 weeks; the birth weight was 1422±604 g. All the premature neonates needed mech...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2014-08-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1411 |
| Summary: | Objective: to evaluate the efficacy of alveofact in neonatal infants with respiratory distress syndrome (RDS). Subjects and methods. The trial enrolled 5 premature neonatal infants. Their mean gestational age was 30.2±2.3 weeks; the birth weight was 1422±604 g. All the premature neonates needed mechanical ventilation (MV) because the leading clinical sign was severe respiratory failure. The surfactant alveofact was injected endotracheally in all the neonates at 3—5 minutes of life, by taking into account their gestational age and birth MV. The mean dose of the agent was 50 mg/kg).Results. The pilot study indicated the efficacy of alveofact. There was normalization of lung gasexchange function parameters after alveofactinjection within the first 24 hours of life. Alveofact administration allows MV with the parameters close to physiological ones. |
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| ISSN: | 1813-9779 2411-7110 |