C-terminal engineering of CXCL12 and CCL5 chemokines: functional characterization by electrophysiological recordings.

C-terminal engineering of CXCL12 and CCL5 chemokines: functional characterization by electrophysiological recordings.

Chemokines are chemotactic cytokines comprised of 70-100 amino acids. The chemokines CXCL12 and CCL5 are the endogenous ligands of the CXCR4 and CCR5 G protein-coupled receptors that are also HIV co-receptors. Biochemical, structural and functional studies of receptors are ligand-consuming and the c...

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Main Authors: Antoine Picciocchi, Lina Siaučiūnaiteė-Gaubard, Isabelle Petit-Hartlein, Rabia Sadir, Jean Revilloud, Lydia Caro, Michel Vivaudou, Franck Fieschi, Christophe Moreau, Corinne Vivès
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3909184?pdf=render

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