Inflammatory abdominal aortic aneurysms: place of Ig G4related diseases
Aim. Inflammatory abdominal aortic aneurysm may be one of the manifestations of Ig G4-related disease. This study analyzes the clinical manifestations of Ig G4related inflammatory abdominal aortic aneurysm.Material and methods. We examined twenty patients with abdominal aortic aneurysm (AAA). The cl...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2019-09-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3035 |
| _version_ | 1797856802133508096 |
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| author | E. D. Zvereva L. B. Mitrofanova O. M. Moiseeva M. A. Chernyavskiy M. L. Gordeev |
| author_facet | E. D. Zvereva L. B. Mitrofanova O. M. Moiseeva M. A. Chernyavskiy M. L. Gordeev |
| author_sort | E. D. Zvereva |
| collection | DOAJ |
| description | Aim. Inflammatory abdominal aortic aneurysm may be one of the manifestations of Ig G4-related disease. This study analyzes the clinical manifestations of Ig G4related inflammatory abdominal aortic aneurysm.Material and methods. We examined twenty patients with abdominal aortic aneurysm (AAA). The clinical performance of the disease, the results of laboratory and pathomorphological studies were studied. In 8 cases, Ig G4-related inflammatory AAA criteria were identified.Results. Compared to atherosclerotic AAA, Ig G4-related cases were characterized by a less frequent presence of abdomen or back pain. The concentration of IgG4 in serum in Ig G4-related cases was significantly increased. Patients with Ig G4-related inflammatory AAA often had a history of allergic reactions to drugs, autoimmune diseases, a high concentration of Ig E and a high titer of antinuclear antibodies in blood serum. According to a histological study of intraoperative biopsy samples, Ig G4-related cases were characterized by thickening of adventitia and numerous infiltrates with Ig G4-positive plasma cells.Conclusion. The presence of Ig G4-related disease is diagnosed in the presence of irregular fibrous tissue proliferation with Ig G4 plasma cell infiltrates and with an increase in the concentration of Ig G4 in blood serum. Ig G4-related inflammatory AAA has clinical specifics in comparison with atherosclerotic aneurysm. |
| first_indexed | 2024-04-09T20:46:22Z |
| format | Article |
| id | doaj.art-355974da11e54052bb1163d7087cc2a8 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:46:22Z |
| publishDate | 2019-09-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-355974da11e54052bb1163d7087cc2a82023-03-29T21:23:32Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202019-09-0108889310.15829/1560-4071-2019-8-88-932592Inflammatory abdominal aortic aneurysms: place of Ig G4related diseasesE. D. Zvereva0L. B. Mitrofanova1O. M. Moiseeva2M. A. Chernyavskiy3M. L. Gordeev4Almazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAim. Inflammatory abdominal aortic aneurysm may be one of the manifestations of Ig G4-related disease. This study analyzes the clinical manifestations of Ig G4related inflammatory abdominal aortic aneurysm.Material and methods. We examined twenty patients with abdominal aortic aneurysm (AAA). The clinical performance of the disease, the results of laboratory and pathomorphological studies were studied. In 8 cases, Ig G4-related inflammatory AAA criteria were identified.Results. Compared to atherosclerotic AAA, Ig G4-related cases were characterized by a less frequent presence of abdomen or back pain. The concentration of IgG4 in serum in Ig G4-related cases was significantly increased. Patients with Ig G4-related inflammatory AAA often had a history of allergic reactions to drugs, autoimmune diseases, a high concentration of Ig E and a high titer of antinuclear antibodies in blood serum. According to a histological study of intraoperative biopsy samples, Ig G4-related cases were characterized by thickening of adventitia and numerous infiltrates with Ig G4-positive plasma cells.Conclusion. The presence of Ig G4-related disease is diagnosed in the presence of irregular fibrous tissue proliferation with Ig G4 plasma cell infiltrates and with an increase in the concentration of Ig G4 in blood serum. Ig G4-related inflammatory AAA has clinical specifics in comparison with atherosclerotic aneurysm.https://russjcardiol.elpub.ru/jour/article/view/3035иммуноглобулин g4воспалительная аневризма брюшной аортыбиомаркерыгистология |
| spellingShingle | E. D. Zvereva L. B. Mitrofanova O. M. Moiseeva M. A. Chernyavskiy M. L. Gordeev Inflammatory abdominal aortic aneurysms: place of Ig G4related diseases Российский кардиологический журнал иммуноглобулин g4 воспалительная аневризма брюшной аорты биомаркеры гистология |
| title | Inflammatory abdominal aortic aneurysms: place of Ig G4related diseases |
| title_full | Inflammatory abdominal aortic aneurysms: place of Ig G4related diseases |
| title_fullStr | Inflammatory abdominal aortic aneurysms: place of Ig G4related diseases |
| title_full_unstemmed | Inflammatory abdominal aortic aneurysms: place of Ig G4related diseases |
| title_short | Inflammatory abdominal aortic aneurysms: place of Ig G4related diseases |
| title_sort | inflammatory abdominal aortic aneurysms place of ig g4related diseases |
| topic | иммуноглобулин g4 воспалительная аневризма брюшной аорты биомаркеры гистология |
| url | https://russjcardiol.elpub.ru/jour/article/view/3035 |
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