BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA
Due to the general trend of changes in reactivity in many exogenous and endogenous diseases, more and more attention is currently being paid to changes in immunological reactivity in drug addiction. The expediency of assessing the state of immune mechanisms in opioid addiction is determined by the n...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2021-10-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/2289 |
| _version_ | 1797197869520781312 |
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| author | K. K. Kulmukanova A. U. Baiduissenova E. A. Akhmediyarova A. A. Yktiyarov G. A. Bekniyazova N. B. Rakhmetova G. K. Smaylova |
| author_facet | K. K. Kulmukanova A. U. Baiduissenova E. A. Akhmediyarova A. A. Yktiyarov G. A. Bekniyazova N. B. Rakhmetova G. K. Smaylova |
| author_sort | K. K. Kulmukanova |
| collection | DOAJ |
| description | Due to the general trend of changes in reactivity in many exogenous and endogenous diseases, more and more attention is currently being paid to changes in immunological reactivity in drug addiction. The expediency of assessing the state of immune mechanisms in opioid addiction is determined by the need to predict their course and outcome. The aim of the study was to study the immunological reactivity of the body in patients with opium addiction in a stage of abstinence. For this purpose, clinical and immunological studies were conducted in 80 patients who use opioid drugs. The duration of the disease ranged from 0.5-19 years. Of these, the disease duration is up to 3 years – 28 patients (group I), and over 3 years – 52 patients (group II). The number of subjects in the control group was n = 50. Authors carried out the assessment of the mental, narcological, somatic, and neurological status. In addition, they have studied the general clinical, biochemical and immunological parameters As a result of this study, it was found, that patients of group I had more pronounced T-lymphocytopenia. A persistent increase in the value of serum IgM was revealed both in the dynamics of abstinence and depending on the duration of the disease, which may indicate a strain on the humoral link of immunity in opium addiction. In addition, as the duration of chronic narcotization increases, there is a tendency to increase the relative number of B-lymphocytes. Thus, at the patients with opium addiction in a state of abstinence develop T-lymphocytopenia. Moreover, with an increase in the duration of the disease, an increase in the level of IgM by 2-2.6 times. The revealed changes in the immunological reactivity of the organism suggest the need to include immunocorrective therapy in the complex of therapeutic measures for opium addiction. |
| first_indexed | 2024-03-08T05:47:25Z |
| format | Article |
| id | doaj.art-355a51eeb4944470a6abe9974ac17464 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:50:49Z |
| publishDate | 2021-10-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-355a51eeb4944470a6abe9974ac174642024-04-22T13:07:47ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2021-10-0123478178410.15789/1563-0625-BIR-22891434BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIAK. K. Kulmukanova0A. U. Baiduissenova1E. A. Akhmediyarova2A. A. Yktiyarov3G. A. Bekniyazova4N. B. Rakhmetova5G. K. Smaylova6Astana Medical UniversityAstana Medical UniversityAstana Medical UniversityAstana Medical UniversityAstana Medical UniversityAstana Medical UniversityAstana Medical UniversityDue to the general trend of changes in reactivity in many exogenous and endogenous diseases, more and more attention is currently being paid to changes in immunological reactivity in drug addiction. The expediency of assessing the state of immune mechanisms in opioid addiction is determined by the need to predict their course and outcome. The aim of the study was to study the immunological reactivity of the body in patients with opium addiction in a stage of abstinence. For this purpose, clinical and immunological studies were conducted in 80 patients who use opioid drugs. The duration of the disease ranged from 0.5-19 years. Of these, the disease duration is up to 3 years – 28 patients (group I), and over 3 years – 52 patients (group II). The number of subjects in the control group was n = 50. Authors carried out the assessment of the mental, narcological, somatic, and neurological status. In addition, they have studied the general clinical, biochemical and immunological parameters As a result of this study, it was found, that patients of group I had more pronounced T-lymphocytopenia. A persistent increase in the value of serum IgM was revealed both in the dynamics of abstinence and depending on the duration of the disease, which may indicate a strain on the humoral link of immunity in opium addiction. In addition, as the duration of chronic narcotization increases, there is a tendency to increase the relative number of B-lymphocytes. Thus, at the patients with opium addiction in a state of abstinence develop T-lymphocytopenia. Moreover, with an increase in the duration of the disease, an increase in the level of IgM by 2-2.6 times. The revealed changes in the immunological reactivity of the organism suggest the need to include immunocorrective therapy in the complex of therapeutic measures for opium addiction.https://www.mimmun.ru/mimmun/article/view/2289immunological reactivityopiomaniapsychiatry and narcologyorganism reactivityopiate addiction |
| spellingShingle | K. K. Kulmukanova A. U. Baiduissenova E. A. Akhmediyarova A. A. Yktiyarov G. A. Bekniyazova N. B. Rakhmetova G. K. Smaylova BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA Медицинская иммунология immunological reactivity opiomania psychiatry and narcology organism reactivity opiate addiction |
| title | BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA |
| title_full | BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA |
| title_fullStr | BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA |
| title_full_unstemmed | BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA |
| title_short | BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA |
| title_sort | body immunological reactivity in opiomania |
| topic | immunological reactivity opiomania psychiatry and narcology organism reactivity opiate addiction |
| url | https://www.mimmun.ru/mimmun/article/view/2289 |
| work_keys_str_mv | AT kkkulmukanova bodyimmunologicalreactivityinopiomania AT aubaiduissenova bodyimmunologicalreactivityinopiomania AT eaakhmediyarova bodyimmunologicalreactivityinopiomania AT aayktiyarov bodyimmunologicalreactivityinopiomania AT gabekniyazova bodyimmunologicalreactivityinopiomania AT nbrakhmetova bodyimmunologicalreactivityinopiomania AT gksmaylova bodyimmunologicalreactivityinopiomania |