Potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsy
Hepatocellular carcinoma (HCC) is one of the most common types of liver cancer that is mainly diagnosed at advanced stages. Since molecular markers that are currently used in clinical practice are not sensitive enough for effective diagnosis of HCC, active search of new biomarkers is underway. Usе o...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-01-01
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| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/170 |
| _version_ | 1826559139670654976 |
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| author | I. F. Kustova A. S. Makarova N. L. Lazarevich |
| author_facet | I. F. Kustova A. S. Makarova N. L. Lazarevich |
| author_sort | I. F. Kustova |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the most common types of liver cancer that is mainly diagnosed at advanced stages. Since molecular markers that are currently used in clinical practice are not sensitive enough for effective diagnosis of HCC, active search of new biomarkers is underway. Usе of minimally invasive liquid biopsy allows to detect specific markers of tumor growth and particularly alterations of gene methylation patterns in cell-free DNA distinctive for HCC, in biological liquids of patients. In the present review the most promising diagnostic and prognostic methylation biomarkers that were detected in cell-free DNA of HCC patients are being considered. |
| first_indexed | 2024-03-12T03:31:36Z |
| format | Article |
| id | doaj.art-355bdfadd37647558f9e12aef817bc86 |
| institution | Directory Open Access Journal |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| last_indexed | 2025-03-14T08:55:38Z |
| publishDate | 2019-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj.art-355bdfadd37647558f9e12aef817bc862025-03-02T12:45:06ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872019-01-015481910.17650/2313-805X-2018-5-4-8-19134Potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsyI. F. Kustova0A. S. Makarova1N. L. Lazarevich2Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaResearch Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaResearch Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Biological Faculty, M.V. Lomonosov Moscow State UniversityHepatocellular carcinoma (HCC) is one of the most common types of liver cancer that is mainly diagnosed at advanced stages. Since molecular markers that are currently used in clinical practice are not sensitive enough for effective diagnosis of HCC, active search of new biomarkers is underway. Usе of minimally invasive liquid biopsy allows to detect specific markers of tumor growth and particularly alterations of gene methylation patterns in cell-free DNA distinctive for HCC, in biological liquids of patients. In the present review the most promising diagnostic and prognostic methylation biomarkers that were detected in cell-free DNA of HCC patients are being considered.https://umo.abvpress.ru/jour/article/view/170hepatocellular carcinomaliquid biopsymethylation biomarker |
| spellingShingle | I. F. Kustova A. S. Makarova N. L. Lazarevich Potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsy Успехи молекулярной онкологии hepatocellular carcinoma liquid biopsy methylation biomarker |
| title | Potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsy |
| title_full | Potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsy |
| title_fullStr | Potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsy |
| title_full_unstemmed | Potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsy |
| title_short | Potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsy |
| title_sort | potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsy |
| topic | hepatocellular carcinoma liquid biopsy methylation biomarker |
| url | https://umo.abvpress.ru/jour/article/view/170 |
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